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ClinicalTrials.gov public records Last synced Oct 13, 2026, 7:36 PM EDT

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Showing 409–432 of 914 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Arthritis of Knee Clear all
Completed Phase 3 Interventional

HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain

NCT00792727
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ketoprofen Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
45 Years and older
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
36
States / cities
Birmingham, Alabama • Chandler, Arizona • Peoria, Arizona + 31 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2015 · Synced Oct 13, 2026, 7:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)

NCT05823727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
SOLUGEL, Placebo
Dietary Supplement
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Not applicable Interventional Results available

Study of Pain Catastrophizing

NCT03836586
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cognitive-Behavioral Intervention, Pain Education
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2024 · Synced Oct 13, 2026, 7:36 PM EDT
Not listed Phase 1 Interventional

Safety Study of PTP-001 for Treating Knee Osteoarthritis

NCT04632966
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Biological: PTP-001
Biological
Lead sponsor
Bioventus LLC
Industry
Eligibility
40 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Durham, North Carolina • North Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 22, 2021 · Synced Oct 13, 2026, 7:36 PM EDT
Terminated Phase 4 Interventional Results available

Knee Injection RCT

NCT03694821
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ketorolac Tromethamine Injection, Methylprednisolone Acetate Injection, Hylan G-F 20
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 13, 2026, 7:36 PM EDT
Not listed Early Phase 1 Interventional

Biofeedback Retention in Individuals With AKA

NCT05126485
View directory record Official record
Conditions
Amputation of Knee, Back Pain, Osteo Arthritis Knee
Interventions
Haptic Biofeedback from SageMotion Biofeedback System
Device
Lead sponsor
San Jose State University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 2 Interventional

A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee

NCT01366014
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ARRY-371797, p38 inhibitor; oral, Oxycodone hydrochloride (HCl) extended release (ER), opioid agonist; oral, Placebo; oral
Drug
Lead sponsor
Pfizer
Industry
Eligibility
40 Years to 85 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
13
States / cities
Phoenix, Arizona • Fort Lauderdale, Florida • Pinellas Park, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 13, 2026, 7:36 PM EDT
Terminated Phase 3 Interventional Results available

Long-Term Study Of The Safety Of Tanezumab In Arthritis Patients

NCT00960804
View directory record Official record
Conditions
Osteoarthritis
Interventions
Tanezumab, Placebo
Biological · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
18
States / cities
Atlantis, Florida • Fort Myers, Florida • South Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 4 Interventional

TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis

NCT00130468
View directory record Official record
Conditions
Osteoarthritis
Interventions
Hyalgan (sodium hyaluronate)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 3, 2008 · Synced Oct 13, 2026, 7:36 PM EDT
Recruiting Not applicable Interventional

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

NCT06857123
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Exercise with Rest, Exercise without Rest
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
45 Years to 79 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

NCT00710840
View directory record Official record
Conditions
Osteoarthritis
Interventions
Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Boulder, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 3 Interventional

A Study of Pain Relief in Osteoarthritis

NCT00298974
View directory record Official record
Conditions
Osteoarthritis
Interventions
hydrocodone / acetaminophen extended release, Placebo
Drug
Lead sponsor
Abbott
Industry
Eligibility
21 Years to 80 Years
Enrollment
873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
83
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 68 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2011 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Not applicable Interventional

Validation of a Low-cost Platelet-Rich Plasma (PRP)

NCT06184048
View directory record Official record
Conditions
Platelet-Rich Plasma (PRP), Knee Osteoarthritis (OA)
Interventions
Intra-Articular knee injection of LC-PRP
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 3 Interventional Results available

Study of Meloxicam Capsules in Subjects With Osteoarthritis of the Knee or Hip

NCT01801735
View directory record Official record
Conditions
Osteoarthritis
Interventions
Meloxicam Test Capsules
Drug
Lead sponsor
Iroko Pharmaceuticals, LLC
Industry
Eligibility
40 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
40
States / cities
Birmingham, Alabama • Phoenix, Arizona • Carmichael, California + 32 more
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Oct 13, 2026, 7:36 PM EDT
Recruiting Phase 4 Interventional

Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

NCT06478186
View directory record Official record
Conditions
Osteoarthritis, Knee, Diabetes Mellitus, Type 2
Interventions
triamcinolone acetonide extended-release injectable suspension; TCA-ER, Triamcinolone Acetonide- Immediate Release;TCA-IR
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
40 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 13, 2026, 7:36 PM EDT
Terminated No phase listed Observational

I-beam and Cruciate Tibial Components Used in Total Knee Replacement

NCT00588783
View directory record Official record
Conditions
Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
Interventions
I-beam design, Cruciate design
Device
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Warsaw, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Oct 13, 2026, 7:36 PM EDT
Terminated Phase 4 Interventional

Lidocaine Patch Versus Celecoxib in Pain From Osteoarthritis of the Knee

NCT00904605
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Lidoderm, Celecoxib
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
20
States / cities
Hueytown, Alabama • Mesa, Arizona • Oro Valley, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2010 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 3 Interventional Results available

Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement

NCT02674386
View directory record Official record
Conditions
Osteoarthritis
Interventions
Investigational Medical Product (IMP) administered in parent study
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
51
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 36 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Oct 13, 2026, 7:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

NCT06105788
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome
Interventions
Exercise
Other
Lead sponsor
University of Texas, El Paso
Other
Eligibility
45 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Oct 13, 2026, 7:36 PM EDT
Terminated Phase 3 Interventional Results available

3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis

NCT04931667
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Lorecivivint
Drug
Lead sponsor
Biosplice Therapeutics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
4
States / cities
Tucson, Arizona • Winter Park, Florida • Oak Brook, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Proof of Concept Study of PEMF (Pulsed Electromagnetic Field) Therapy in Subjects With Osteoarthritis of the Knee

NCT02696083
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Provant Therapy System
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
45 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Lone Tree, Colorado • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jan 12, 2018 · Synced Oct 13, 2026, 7:36 PM EDT
Recruiting Not applicable Interventional

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

NCT04472702
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
cRFA
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
35 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Sacramento, California • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty

NCT01651806
View directory record Official record
Conditions
Osteoarthritis, Intraoperative Bleeding
Interventions
Tranexamic Acid standard dose, Females Tranexamic Acid weighted dose, Females receiving a uniform dose of TA, Males Weighted Dose TA
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 13, 2026, 7:36 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis

NCT05064735
View directory record Official record
Conditions
Obesity
Interventions
semaglutide 2.4 mg, semaglutide 2.4 mg (placebo)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
Not listed
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
61
States / cities
Montgomery, Alabama • Phoenix, Arizona • Anaheim, California + 52 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Oct 13, 2026, 7:36 PM EDT