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ClinicalTrials.gov public records Last synced Oct 10, 2026, 3:57 PM EDT

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Showing 121–144 of 914 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Arthritis of Knee Clear all
Completed Not applicable Interventional

Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement

NCT01373099
View directory record Official record
Conditions
Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions
Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 10, 2026, 3:57 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

NANOVAE to Treat Knee Osteoarthritis (KOA)

NCT06606561
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
NANOVAE - Acellular Allogenic Human Amniotic Fluid (hAF), 0.9% Sodium Chloride Injection, USP
Drug
Lead sponsor
Nova Vita Laboratory
Industry
Eligibility
21 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Phase 3 Interventional

A Study of Pain Relief in Osteoarthritis

NCT00298974
View directory record Official record
Conditions
Osteoarthritis
Interventions
hydrocodone / acetaminophen extended release, Placebo
Drug
Lead sponsor
Abbott
Industry
Eligibility
21 Years to 80 Years
Enrollment
873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
83
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 68 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2011 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Exploring Massage Benefits for Arthritis of the Knee

NCT01537484
View directory record Official record
Conditions
Osteoarthritis
Interventions
Massage Therapy
Procedure
Lead sponsor
Duke University
Other
Eligibility
35 Years and older
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
3
States / cities
Derby, Connecticut • Morristown, New Jersey • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Evaluation of DVD and Internet Decision Aids for Hip and Knee Osteoarthritis: Focus on Health Literacy

NCT01618097
View directory record Official record
Conditions
Osteoarthritis
Interventions
DVD Decision Aid, Internet Based Decision Aid
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Oct 10, 2026, 3:57 PM EDT
Active, not recruiting Phase 3 Interventional

Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis

NCT04440189
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
GID SVF-2 Device System
Device
Lead sponsor
GID BIO, Inc.
Industry
Eligibility
35 Years to 85 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
9
States / cities
Sacramento, California • Coral Springs, Florida • New Orleans, Louisiana + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Evaluation of Amniotic Fluid Product in Knee Osteoarthritis

NCT02768155
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Amniotic Fluid 4.0ml dose, Amniotic Fluid 2.0ml dose, Placebo Control
Other
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
30 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Birmingham, Alabama • Des Plaines, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Phase 4 Interventional

TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis

NCT00130468
View directory record Official record
Conditions
Osteoarthritis
Interventions
Hyalgan (sodium hyaluronate)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 3, 2008 · Synced Oct 10, 2026, 3:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Prospective Study to Evaluate Robot Assisted Total Knee Replacement Outcomes

NCT03523897
View directory record Official record
Conditions
Primary Osteoarthritis of Knee Nos
Interventions
Robot Assisted Total Knee Replacement, Traditional Total Knee Replacement
Procedure
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 10, 2026, 3:57 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Astaxanthin for Management of Inflammation in Knee Osteoarthritis

NCT05138549
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
Interventions
Astaxanthin, Placebo
Drug · Other
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years to 99 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Home Monitoring After Primary Total Knee Arthroplasty

NCT03032068
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
At-Home Monitoring
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Oct 10, 2026, 3:57 PM EDT
Active, not recruiting Not applicable Interventional

Prospective Randomized Study of Cementless vs Cemented UKA

NCT05377450
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Engage Partial Knee
Device
Lead sponsor
JIS Research Institute
Other
Eligibility
21 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New Albany, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Oct 10, 2026, 3:57 PM EDT
Terminated Not applicable Interventional Results available

Triathlon® Partial Knee Replacement (PKR) Outcomes Study

NCT00966979
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon PKR
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
21 Years to 75 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2023
U.S. locations
6
States / cities
Jacksonville, Florida • Egg Harbor, New Jersey • Buffalo, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

In Vivo Three-Dimensional Determination of Osteoarthritis Brace Effectiveness

NCT04111276
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Breg Osteoarthritis Brace gait fluoroscopy, Gait fluoroscopy without brace, JointVue ultrasound, Computer Tomography
Device · Other · Diagnostic Test
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Denver, Colorado • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 10, 2026, 3:57 PM EDT
Terminated Phase 4 Interventional

Celebrex Total Knee Arthroplasty Study

NCT00359151
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Celecoxib, Placebo
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
7
States / cities
Aurora, Colorado • Englewood, Colorado • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee

NCT00979953
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ADL5859, ADL5747, Oxycodone CR, Placebo
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 75 Years
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
11
States / cities
Daytona Beach, Florida • Stockbridge, Georgia • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2015 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Phase 2 Interventional Results available

Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee

NCT02116972
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
FX006 32 mg, Placebo, FX006 16 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
39
States / cities
Anniston, Alabama • Birmingham, Alabama • Mobile, Alabama + 36 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis

NCT02905240
View directory record Official record
Conditions
Osteoarthritis
Interventions
nSTRIDE APS, Saline
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 80 Years
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
27
States / cities
Birmingham, Alabama • Guntersville, Alabama • Tucson, Arizona + 24 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA

NCT02110238
View directory record Official record
Conditions
Osteoarthritis
Interventions
Supartz, Euflexxa
Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
40 Years to 80 Years
Enrollment
421 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Oct 10, 2026, 3:57 PM EDT
Enrolling by invitation Phase 4 Interventional

Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance

NCT07544576
View directory record Official record
Conditions
Knee Arthritis Osteoarthritis
Interventions
Triamcinolone knee injection without ultrasound guidance, Triamcinolone knee injection with ultrasound guidance
Drug · Combination Product
Lead sponsor
Sosi Dzhugarian
Other
Eligibility
50 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 10, 2026, 3:57 PM EDT
Not listed Phase 2 Interventional

Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee

NCT00597415
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
celecoxib, placebo
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
45 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Beachwood, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 18, 2008 · Synced Oct 10, 2026, 3:57 PM EDT
Not listed Phase 2 Interventional

Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain

NCT05470608
View directory record Official record
Conditions
Osteoarthritis, Knee Pain
Interventions
SL-1002, Placebo
Drug
Lead sponsor
Saol Therapeutics Inc
Industry
Eligibility
35 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
15
States / cities
Greenwood Village, Colorado • Washington D.C., District of Columbia • Coral Gables, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Oct 10, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cost-Effectiveness of and Long-Term Outcomes Following Acupuncture Treatment for Osteoarthritis of the Knee

NCT00010647
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Acupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
50 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2004
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 10, 2026, 3:57 PM EDT
Recruiting No phase listed Observational

geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

NCT07380906
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Genicular Artery Embolization
Procedure
Lead sponsor
Joint & Vascular Institute
Industry
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Libertyville, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 10, 2026, 3:57 PM EDT