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ClinicalTrials.gov public records Last synced Nov 1, 2026, 4:03 AM EST

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Showing 1897–1920 of 5,569 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Conditions, Neurologic Clear all
Not yet recruiting No phase listed Observational

Revealing Engagement Dynamics Among Semantic Dementia Patients

NCT06218732
View directory record Official record
Conditions
Semantic Dementia
Interventions
Not listed
Lead sponsor
Power Life Sciences Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Nov 1, 2026, 4:03 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease

NCT05179187
View directory record Official record
Conditions
Parkinson Disease
Interventions
Movement task
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Terminated Phase 2Phase 3 Interventional

Safety and Efficacy Study of CEP-1347 in the Treatment of Parkinson's Disease

NCT00040404
View directory record Official record
Conditions
Parkinson Disease
Interventions
CEP-1347 10mg, CEP1347 25mg, CEP-1347 50mg, Placebo Comparator
Drug · Other
Lead sponsor
Cephalon
Industry
Eligibility
30 Years and older
Enrollment
806 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
56
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated May 10, 2012 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 3 Interventional Results available

The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia

NCT01987219
View directory record Official record
Conditions
Familial Dysautonomia
Interventions
Albuterol-sulphate, Ipratropium-bromide, placebo
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
12 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2016 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 1 Interventional

Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease

NCT03065192
View directory record Official record
Conditions
Idiopathic Parkinson's Disease, Parkinson's Disease, Basal Ganglia Disease, Brain Diseases, Central Nervous System Diseases, Movement Disorders, Nervous System Diseases, Neurodegenerative Diseases, Parkinsonian Disorders
Interventions
VY-AADC01
Drug
Lead sponsor
Neurocrine Biosciences
Industry
Eligibility
40 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
4
States / cities
San Francisco, California • Atlanta, Georgia • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Nov 1, 2026, 4:03 AM EST
Recruiting Phase 3 Interventional

A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's

NCT04664634
View directory record Official record
Conditions
Dysphagia, Parkinson Disease
Interventions
Aria Sensor
Device
Lead sponsor
Northwestern University
Other
Eligibility
22 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 2Phase 3 Interventional Results available

HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose

NCT05136885
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
SLS-005, Matching Placebo
Drug
Lead sponsor
Merit E. Cudkowicz, MD
Other
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 3 Interventional Results available

Sarizotan HC1 in Patients With Parkinson's Disease Suffering From Treatment-associated Dyskinesia

NCT00105508
View directory record Official record
Conditions
Parkinson's Disease, Dyskinesia
Interventions
Sarizotan, Placebo
Drug
Lead sponsor
EMD Serono
Industry
Eligibility
30 Years and older
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
31
States / cities
Birmingham, Alabama • Huntsville, Alabama • La Jolla, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk

NCT03688126
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Self-Guided Lifestyle Intervention, Structured Lifestyle Intervention
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years to 79 Years
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
6
States / cities
Sacramento, California • Chicago, Illinois • Downers Grove, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional

Physiological Investigations of Movement Disorders

NCT01019343
View directory record Official record
Conditions
Parkinson's Disease, Tourette's Syndrome, Tic Disorders, Dystonia, Movement Disorders
Interventions
Transcranial Direct Current Stimulation (tDCS), Eye-tracking Device, Pulsed vibrator, Gait Trainer Treadmill (GTT), Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA, iMobility, QMAT, Treadmill Test, Arm Intellistretch Device, Transcranial Sonography (TCS), Behavioral tasks, TMS single/paired pulse, MEG, EEG, MRI techniques, Peripheral Nerve Stimulation, EMG, Trancutaneous spinal direct current stimulation (tsDCS)
Procedure · Device · Other + 1 more
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
1,273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional Results available

Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury

NCT04073225
View directory record Official record
Conditions
Traumatic Brain Injury, Dementia Alzheimers, Military Activity
Interventions
MindPod Dolphin, 10 Keys to Healthy Aging
Device · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
40 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 2 Interventional Results available

Rasagiline Rescue in Alzheimer's Disease Clinical Trial

NCT02359552
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Rasagiline, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
50 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
3
States / cities
Las Vegas, Nevada • Cleveland, Ohio • Lakewood, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 10, 2020 · Synced Nov 1, 2026, 4:03 AM EST
Completed No phase listed Observational

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

NCT01568658
View directory record Official record
Conditions
Muscular Dystrophies, Muscle Myopathies, Hereditary Spastic Paraplegias, Inherited Neuropathies, Inherited Neuromuscular Conditions
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
1 Day to 100 Years
Enrollment
2,586 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 30, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Studying the Effects of Antihypertensives on Individuals at Risk for Alzheimer's

NCT00980785
View directory record Official record
Conditions
Alzheimer's Disease, Hypertension
Interventions
Ramipril, Placebo
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
40 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 25, 2020 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sing for Your Saunter

NCT04246476
View directory record Official record
Conditions
Parkinson Disease
Interventions
Mentally singing, Listening to music
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
30 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

EPIC: An Intervention for Early-stage AD Dyads - Adapted for Virtual Delivery

NCT03144921
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Memory Loss
Interventions
psychoeducational skills training intervention
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
272 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Nov 1, 2026, 4:03 AM EST
Terminated Phase 2 Interventional

Safety and Efficacy Study of ABT-089 in Adults With Mild to Moderate Alzheimer's Disease

NCT00555204
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
ABT-089, placebo
Drug
Lead sponsor
Abbott
Industry
Eligibility
55 Years to 90 Years
Enrollment
337 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
42
States / cities
Phoenix, Arizona • Sun City, Arizona • Fresno, California + 38 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2011 · Synced Nov 1, 2026, 4:03 AM EST
Completed Early Phase 1 Interventional

PET/MRI Evaluation of Cardiac Amyloid

NCT03119558
View directory record Official record
Conditions
Cardiac Amyloidosis
Interventions
18F-Florbetaben (Neuraceq®) PET/MRI
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Nov 1, 2026, 4:03 AM EST
Active, not recruiting Not applicable Interventional

Daily Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease

NCT04055376
View directory record Official record
Conditions
Alzheimer Disease, Alzheimer Dementia
Interventions
GENUS device (Active Settings), GENUS device (Sham Settings)
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
50 Years to 100 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional

Reducing Risk of Dementia Through Deprescribing

NCT04270474
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Late Onset
Interventions
Deprescribing of target anticholinergics, Usual Care
Other
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Completed Not applicable Interventional

Vaccination Uptake (VAX) in PD

NCT02874274
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Standard of Care, Home Visit Program (HVP)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
65 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2020 · Synced Nov 1, 2026, 4:03 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Detecting Dopaminergic Deficits in Individuals At-risk for Parkinsonism

NCT01358474
View directory record Official record
Conditions
Parkinson Disease, Gaucher Disease, Idiopathic Rapid Eye Movement Sleep Disorder
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Nov 1, 2026, 4:03 AM EST
Completed Phase 4 Interventional Results available

A Study to Learn About the Effect of Nusinersen (BIIB058) Given as Injections to Children With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene Abeparvovec (RESPOND)

NCT04488133
View directory record Official record
Conditions
Muscular Atrophy, Spinal
Interventions
Nusinersen
Drug
Lead sponsor
Biogen
Industry
Eligibility
2 Months to 36 Months
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
9
States / cities
Little Rock, Arkansas • Palo Alto, California • Aurora, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2026 · Synced Nov 1, 2026, 4:03 AM EST
Recruiting Not applicable Interventional

Investigating Inhibitory Control Networks in Parkinson's Disease

NCT04735458
View directory record Official record
Conditions
Parkinson Disease
Interventions
Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Nov 1, 2026, 4:03 AM EST