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ClinicalTrials.gov public records Last synced Oct 9, 2026, 12:18 PM EDT

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Showing 121–144 of 145 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Disc Disease Lumbar Clear all
Terminated No phase listed Observational

The Effectiveness of Anti-Gravity Treadmill Training

NCT01689922
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
AlterG
Other
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 1, 2017 · Synced Oct 9, 2026, 12:18 PM EDT
Completed No phase listed Observational

Retro Comparison of Subsidence Following Interbody Devices in Lumbar Spine

NCT05536453
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
Lumbar Interbody Fusion Devices
Device
Lead sponsor
Spine and Scoliosis Research Associates
Other
Eligibility
18 Years to 110 Years
Enrollment
465 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
San Francisco, California • New York, New York • Charlotte, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 9, 2026, 12:18 PM EDT
Not listed Not applicable Interventional

OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study

NCT05405374
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
Interventions
OSTEOAMP, Infuse
Other · Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
9
States / cities
New Haven, Connecticut • Wichita, Kansas • Paducah, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2023 · Synced Oct 9, 2026, 12:18 PM EDT
Recruiting Not applicable Interventional

MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

NCT05037968
View directory record Official record
Conditions
Degenerative Disc Disease, Spine Fusion, Leg Pain and/or Back Pain
Interventions
MagnetOs Flex Matrix, Trinity Elite
Device
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
8
States / cities
Hartford, Connecticut • Chicago, Illinois • Columbia, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 9, 2026, 12:18 PM EDT
Not yet recruiting Not applicable Interventional

Kore Fiber PLF RCT

NCT07868510
View directory record Official record
Conditions
Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Spondylolisthesis
Interventions
Kore Fiber, Autologous bone graft
Biological · Other
Lead sponsor
Kolosis Bio, LLC
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 9, 2026, 12:18 PM EDT
Recruiting No phase listed Observational

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

NCT05648474
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Interventions
Somatosensory evoked potential [SSEP] intraoperative monitoring
Diagnostic Test
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 9, 2026, 12:18 PM EDT
Active, not recruiting No phase listed Observational

Observational Study to Evaluate the STALIF® C FLX, STALIF® M FLX, STALIF® L FLX Cages and FORTOS-C®

NCT06876311
View directory record Official record
Conditions
Degenerative Cervical Disc Disease, Degenerative Lumbar Diseases
Interventions
Anterior Cervical Interbody Fusion, Anterior lumbar Interbody Fusion, Lateral Lumbar Interbody Fusion
Device
Lead sponsor
Silony Medical GmbH
Industry
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
San Ramon, California
Source: ClinicalTrials.gov public record
Updated Mar 14, 2025 · Synced Oct 9, 2026, 12:18 PM EDT
Not listed No phase listed Observational

Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft

NCT01746212
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
One-level or two-level anterior lumbar interbody fusion, InQu Bone Graft Extender and Substitute mixed with BMAC, Synthes Spinal Instrumentation
Procedure · Biological · Device
Lead sponsor
Kansas Joint and Spine Institute
Network
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2012 · Synced Oct 9, 2026, 12:18 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Efficacy of Using Solum IV and BMC With GFC in TLIF

NCT03223701
View directory record Official record
Conditions
Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion
Combination Product
Lead sponsor
Seton Healthcare Family
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 18, 2018 · Synced Oct 9, 2026, 12:18 PM EDT
Completed No phase listed Observational

A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures

NCT01972256
View directory record Official record
Conditions
Pseudoarthrosis, Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
Interventions
Not listed
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
5
States / cities
Tampa, Florida • Indianapolis, Indiana • Baton Rouge, Louisiana + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2014 · Synced Oct 9, 2026, 12:18 PM EDT
Completed Phase 1 Interventional

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

NCT03347708
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
IDCT, Saline Solution, Sodium Hyaluronate
Biological · Drug
Lead sponsor
DiscGenics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 9, 2026, 12:18 PM EDT
Not listed No phase listed Observational

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

NCT05146583
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only
Procedure
Lead sponsor
New York Presbyterian Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2021 · Synced Oct 9, 2026, 12:18 PM EDT
Recruiting No phase listed Observational

OssiMend BA in Posterolateral Instrumented Lumbar Fusion

NCT04775537
View directory record Official record
Conditions
Spinal Disease, Degenerative Disc Disease
Interventions
OssiMend™ Bioactive Moldable
Device
Lead sponsor
Collagen Matrix
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
4
States / cities
Encinitas, California • Hartford, Connecticut • Somerset, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 9, 2026, 12:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ISOVUE Comparative Trial

NCT07363759
View directory record Official record
Conditions
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
Interventions
ISOVUE 300 Observation, ISOVUE 300 Feedback
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 9, 2026, 12:18 PM EDT
Not listed No phase listed Observational

Prospective Study of Safety and Efficacy of InQu® Bone Graft Extender in Lumbar Interbody Fusion Surgery

NCT02400762
View directory record Official record
Conditions
Intervertebral Disc Degeneration
Interventions
Not listed
Lead sponsor
ISTO Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
2
States / cities
Los Angeles, California • Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 9, 2026, 12:18 PM EDT
Completed No phase listed Observational Results available

Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device

NCT01944345
View directory record Official record
Conditions
Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1, Intervertebral Disc Displacement
Interventions
Not listed
Lead sponsor
Wenzel Spine
Industry
Eligibility
18 Years to 99 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Boston, Massachusetts • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Oct 9, 2026, 12:18 PM EDT
Withdrawn Phase 3 Interventional

Peri-Incisional Drug Injection in Lumbar Spine Surgery

NCT03513445
View directory record Official record
Conditions
Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions
Morphine, Epinephrine, naropin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 9, 2026, 12:18 PM EDT
Completed Not applicable Interventional

Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery

NCT03442374
View directory record Official record
Conditions
Disc Degeneration, Low Back Pain
Interventions
Exercise
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 85 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 9, 2026, 12:18 PM EDT
Terminated Not applicable Interventional

Comparative Analysis of Virtuos and Autograft in Lumbar Fusion

NCT05614284
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Virtuos
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
New Britain, Connecticut • Royal Oak, Michigan • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 9, 2026, 12:18 PM EDT
Terminated No phase listed Observational

OLIF25™ /OLIF51™ Study

NCT02657421
View directory record Official record
Conditions
Degenerative Disc Disease, Scoliosis
Interventions
Oblique Lateral Interbody Fusion
Procedure
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Murrieta, California • San Francisco, California • Melbourne, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2018 · Synced Oct 9, 2026, 12:18 PM EDT
Terminated Phase 3 Interventional Results available

Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System

NCT01011816
View directory record Official record
Conditions
Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
Interventions
BIOSTAT BIOLOGX, Saline
Biological · Drug
Lead sponsor
Spinal Restoration, Inc.
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
20
States / cities
Birmingham, Alabama • Phoenix, Arizona • Chula Vista, California + 17 more
Source: ClinicalTrials.gov public record
Updated May 16, 2014 · Synced Oct 9, 2026, 12:18 PM EDT
Recruiting Phase 3 Interventional

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

NCT07254806
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
IDCT (rebonuputemcel), Sham (No Treatment)
Biological · Other
Lead sponsor
DiscGenics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 26 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 9, 2026, 12:18 PM EDT
Completed Phase 3 Interventional

XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)

NCT00927238
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
XL TDR, Lumbar fusion surgery
Device · Other
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
17
States / cities
Campbell, California • Thousand Oaks, California • Durango, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 9, 2026, 12:18 PM EDT
Terminated Not applicable Interventional

Regenexx™ PL-Disc Versus Steroid Epidurals for Lumbar Radiculopathy

NCT01850771
View directory record Official record
Conditions
Radiculopathy, Herniated Disc, Disc Degeneration
Interventions
Regenexx PL-Disc, Steroid Epidural
Procedure
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 3, 2016 · Synced Oct 9, 2026, 12:18 PM EDT