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ClinicalTrials.gov public records Last synced Oct 2, 2026, 3:22 PM EDT

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Showing 25–48 of 180 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Lumbar Diseases Clear all
Completed Not applicable Interventional

A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions

NCT00679107
View directory record Official record
Conditions
Degenerative Lumbar Spondylolisthesis
Interventions
Use of OP-1 Putty in Uninstrumented posterolateral fusion
Device
Lead sponsor
Olympus Biotech Corporation
Industry
Eligibility
18 Years to 81 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
5
States / cities
New Haven, Connecticut • Chicago, Illinois • Royal Oak, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2011 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 1 Interventional

Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

NCT03347708
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
IDCT, Saline Solution, Sodium Hyaluronate
Biological · Drug
Lead sponsor
DiscGenics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated No phase listed Observational

Radiographic and Clinical Outcomes of PureGen in Posterior Lumbar (PLIF) and Transforaminal Interbody Fusion (TLIF)

NCT01293981
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
PureGen Osteoprogenitor Cell Allograft
Biological
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
3
States / cities
Beverly Hills, California • Middleton, Connecticut • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2016 · Synced Oct 2, 2026, 3:22 PM EDT
Recruiting Phase 4 Interventional

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

NCT05029726
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions
Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
Drug
Lead sponsor
John O'Toole
Other
Eligibility
18 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Not applicable Interventional

A-MAV™ Anterior Motion Segment Replacement

NCT00635934
View directory record Official record
Conditions
Spinal Diseases
Interventions
A-MAV™ disc
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years to 70 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Columbus, Georgia • Chesterfield, Missouri • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Oct 2, 2026, 3:22 PM EDT
Withdrawn Not applicable Interventional

Proprio Spine Measurement Tool

NCT07023393
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis, Spinal Osteophytosis, Spinal Stenosis, Spondylitis, Spondylosis
Interventions
Intraoperative spinal measurement system
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 2, 2026, 3:22 PM EDT
Active, not recruiting Not applicable Interventional

P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation

NCT03438747
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
P-15L Bone Graft, Local autologous bone in a TLIF with Instrumentation
Device · Other
Lead sponsor
CeraPedics, Inc
Industry
Eligibility
22 Years to 80 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
34
States / cities
Birmingham, Alabama • Glendale, California • Los Angeles, California + 27 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated No phase listed Observational

Interbody Systems: Post Market Clinical Follow-up Study

NCT04911257
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical or Lumbar Spinal fusion
Device
Lead sponsor
K2M, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Shreveport, Louisiana • Cleveland, Ohio • Oklahoma City, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated No phase listed Observational

OLIF25™ /OLIF51™ Study

NCT02657421
View directory record Official record
Conditions
Degenerative Disc Disease, Scoliosis
Interventions
Oblique Lateral Interbody Fusion
Procedure
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Murrieta, California • San Francisco, California • Melbourne, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2018 · Synced Oct 2, 2026, 3:22 PM EDT
Recruiting No phase listed Observational

Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper Prime

NCT06704906
View directory record Official record
Conditions
Spondylolisthesis, Lumbar Region, Spinal Trauma With Neurological Deficit, Degeneration of Lumbar Intervertebral Disc
Interventions
Use of Viper Prime/Expedium system with Fibergraft BG Putty
Device
Lead sponsor
Nitin Agarwal
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated Not applicable Interventional

Comparative Analysis of Virtuos and Autograft in Lumbar Fusion

NCT05614284
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Virtuos
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
New Britain, Connecticut • Royal Oak, Michigan • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease

NCT03692221
View directory record Official record
Conditions
Disc Degeneration
Interventions
MSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment)
Drug · Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 2 Interventional

Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery

NCT06199999
View directory record Official record
Conditions
Postoperative Delirium, Pain, Postoperative, Degenerative Disc Disease
Interventions
Erector Spinae Block, Local infiltration with local anesthetic
Procedure
Lead sponsor
Rashmi Mueller
Other
Eligibility
18 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 2, 2026, 3:22 PM EDT
Not listed No phase listed Observational

Clinical and Radiographic Outcomes of TLIF w/3D Printed Cellular Implant

NCT05023733
View directory record Official record
Conditions
Foraminal Stenosis, Degenerative Disc Disease, Lumbar Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
CONDUIT™ Interbody Platform composed of the EIT (Emerging Implant Technologies) Cellular Titanium®
Device
Lead sponsor
Farhan Karim
Other
Eligibility
35 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 28, 2022 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Not applicable Interventional Results available

Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® Disc Augmentation System: A Pilot Study

NCT00693784
View directory record Official record
Conditions
Low Back Pain
Interventions
Biostat® Disc Augmentation System
Biological
Lead sponsor
Spinal Restoration, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
3
States / cities
Bethesda, Maryland • Tyler, Texas • Bellingham, Washington
Source: ClinicalTrials.gov public record
Updated Jun 22, 2015 · Synced Oct 2, 2026, 3:22 PM EDT
Not listed No phase listed Observational

Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft

NCT01746212
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
One-level or two-level anterior lumbar interbody fusion, InQu Bone Graft Extender and Substitute mixed with BMAC, Synthes Spinal Instrumentation
Procedure · Biological · Device
Lead sponsor
Kansas Joint and Spine Institute
Network
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2012 · Synced Oct 2, 2026, 3:22 PM EDT
Not listed Phase 4 Interventional

Dronabinol for Post-operative Pain After Lumbar Fusion

NCT04346407
View directory record Official record
Conditions
Post-operative Pain
Interventions
Dronabinol 2.5mg Cap, Placebo
Drug
Lead sponsor
Jeffrey L Gum MD
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 12, 2021 · Synced Oct 2, 2026, 3:22 PM EDT
Not listed No phase listed Observational

Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures

NCT02171169
View directory record Official record
Conditions
Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
Interventions
Not listed
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
3
States / cities
Fullerton, California • Waterford, Michigan • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2014 · Synced Oct 2, 2026, 3:22 PM EDT
Recruiting No phase listed Observational

OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

NCT05452694
View directory record Official record
Conditions
Lumbar Spine Stenosis, Lumbar Spine Degeneration
Interventions
Not listed
Lead sponsor
OpalGenix, Inc
Industry
Eligibility
18 Years to 99 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated Phase 3 Interventional Results available

INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine

NCT01415908
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
INFUSE Bone Graft, Iliac Crest Bone Graft
Device · Other
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Mesa, Arizona • Los Angeles, California • Gulf Breeze, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Oct 2, 2026, 3:22 PM EDT
Terminated Phase 2 Interventional

Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease

NCT00878579
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
PDS System, Fusion
Device
Lead sponsor
Interventional Spine, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Cincinnati, Ohio • Willow Grove, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 21, 2013 · Synced Oct 2, 2026, 3:22 PM EDT
Completed No phase listed Observational

A Prospective Non-concurrent Controlled Evaluation of Open and MAS® PLIF

NCT01640977
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
Open PLIF (posterior lumbar interbody fusion), MAS PLIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
4
States / cities
Greensboro, North Carolina • York, Pennsylvania • Temple, Texas
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Enrolling by invitation No phase listed Observational

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

NCT06000319
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Induce Biologics USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 2, 2026, 3:22 PM EDT
Completed Phase 3 Interventional

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

NCT00215319
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Lumbar I/F with cage and pedicle screws
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
18 Years to 79 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
2
States / cities
Dothan, Alabama • Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 23, 2014 · Synced Oct 2, 2026, 3:22 PM EDT