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ClinicalTrials.gov public records Last synced Sep 17, 2026, 5:15 AM EDT

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Showing 1–24 of 298 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Degenerative Spine Disease Clear all
Not listed Not applicable Interventional

SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2

NCT04566874
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Scoliosis
Interventions
ALIF
Device
Lead sponsor
Camber Spine Technologies
Industry
Eligibility
22 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Sep 17, 2026, 5:15 AM EDT
Recruiting Not applicable Interventional

ACDF Using Structural Allograft vs. Tritanium C

NCT04388332
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Structural allograft, Tritanium C
Procedure · Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 17, 2026, 5:15 AM EDT
Terminated Not applicable Interventional

Comparative Analysis of Virtuos and Autograft in Lumbar Fusion

NCT05614284
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Virtuos
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
New Britain, Connecticut • Royal Oak, Michigan • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Sep 17, 2026, 5:15 AM EDT
Terminated Not applicable Interventional

Regenexx™ PL-Disc Versus Steroid Epidurals for Lumbar Radiculopathy

NCT01850771
View directory record Official record
Conditions
Radiculopathy, Herniated Disc, Disc Degeneration
Interventions
Regenexx PL-Disc, Steroid Epidural
Procedure
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 2, 2016 · Synced Sep 17, 2026, 5:15 AM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel

NCT01028300
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ProDisc™-L Total Disc Replacement (TDR)
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2016 · Synced Sep 17, 2026, 5:15 AM EDT
Enrolling by invitation No phase listed Observational

Posterior Cervical Fixation Study

NCT04770571
View directory record Official record
Conditions
Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease, Cervical Fusion, Cervical Spine Disease, Cervical Myelopathy, Cervical Instabilities Spine, Thoracic Injury
Interventions
observational study
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Hyattsville, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 17, 2026, 5:15 AM EDT
Active, not recruiting Not applicable Interventional

Non-surgical Spinal Decompression Therapy and Outcomes

NCT06525896
View directory record Official record
Conditions
Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions
NSSD, Sham NSSD
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Stanford, California • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 17, 2026, 5:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease

NCT00589797
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Activ-L Artificial Disc, ProDisc-L Total Disc Replacement or Charité Artificial Disc
Device
Lead sponsor
Aesculap Implant Systems
Industry
Eligibility
18 Years to 60 Years
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2017
U.S. locations
17
States / cities
La Jolla, California • Newport Beach, California • Rancho Cucamonga, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2018 · Synced Sep 17, 2026, 5:15 AM EDT
Completed No phase listed Observational

PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries

NCT01406405
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Posterior/Transforaminal Lumbar Interbody Fusion (P/TLIF), Anterior Cervical Discectomy and Fusion (ACDF)
Procedure
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Sep 17, 2026, 5:15 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain

NCT06053242
View directory record Official record
Conditions
Chronic Low-back Pain, Degenerative Disc Disease
Interventions
CELZ-201-DDT, Placebo
Drug · Other
Lead sponsor
Creative Medical Technology Holdings Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 17, 2026, 5:15 AM EDT
Terminated Not applicable Interventional

Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)

NCT00374413
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
Artificial disk, Artificial disc
Device
Lead sponsor
SpinalMotion
Industry
Eligibility
18 Years to 60 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
21
States / cities
Beverly Hills, California • Oakland, California • San Diego, California + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2013 · Synced Sep 17, 2026, 5:15 AM EDT
Terminated Phase 3 Interventional Results available

A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis

NCT00697827
View directory record Official record
Conditions
Spinal Stenosis
Interventions
Interspinous Spacer device, Interspinous Process Distraction Device
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
50 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
10
States / cities
Santa Monica, California • New Haven, Connecticut • Minneapolis, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2012 · Synced Sep 17, 2026, 5:15 AM EDT
Active, not recruiting Not applicable Interventional

Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels

NCT04214535
View directory record Official record
Conditions
Cervical Disc Herniation, Cervical Disc Degeneration, Degenerative Disc Disease
Interventions
Tritanium C Anterior Cervical Cage
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 17, 2026, 5:15 AM EDT
Completed No phase listed Observational

CHARITE™ vs. ALIF 5-Year Follow-up

NCT00215332
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
CHARITE
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
Not listed
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
10
States / cities
Los Angeles, California • Golden, Colorado • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2015 · Synced Sep 17, 2026, 5:15 AM EDT
Recruiting No phase listed Observational

Thoracic-Lumbar Arthrodesis- Implanet Jazz

NCT05366140
View directory record Official record
Conditions
Spondylolisthesis, Spinal Stenosis, Degenerative Disease
Interventions
Prospective follow-up of patients who have received instrumented lumbar arthrodesis supplemented the Implanet Jazz System(TM)
Other
Lead sponsor
Francis Farhadi
Other
Eligibility
18 Years to 100 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 17, 2026, 5:15 AM EDT
Recruiting No phase listed Observational

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

NCT05648474
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Interventions
Somatosensory evoked potential [SSEP] intraoperative monitoring
Diagnostic Test
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 17, 2026, 5:15 AM EDT
Recruiting Not applicable Interventional

Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation

NCT06407427
View directory record Official record
Conditions
Spine Degeneration, Hip Arthritis, Knee Osteoarthritis, Hip Fractures
Interventions
App for in-bed conditioning exercises, Usual care
Device · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 17, 2026, 5:15 AM EDT
Terminated No phase listed Observational

Single Position Spine Surgery Registry

NCT04839783
View directory record Official record
Conditions
Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Spine and Scoliosis Research Associates
Other
Eligibility
18 Years to 100 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
5
States / cities
Boston, Massachusetts • New York, New York • Wilmington, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 17, 2026, 5:15 AM EDT
Completed No phase listed Observational

Validation of Appropriateness Criteria for the Surgical Treatment of Lumbar Degenerative Spondylolisthesis

NCT02966639
View directory record Official record
Conditions
Spondylolisthesis
Interventions
Not listed
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 8, 2021 · Synced Sep 17, 2026, 5:15 AM EDT
Recruiting Phase 3 Interventional

Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease

NCT07017634
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Novosis Putty, Standard of Care
Device · Other
Lead sponsor
CGBio Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
10
States / cities
Little Rock, Arkansas • Sacramento, California • Miami, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 17, 2026, 5:15 AM EDT
Completed Not applicable Interventional

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine

NCT02023372
View directory record Official record
Conditions
Intervertebral Disc Disease, Intervertebral Disc Degeneration, Spondylosis, Spondylolisthesis, Spinal Stenosis
Interventions
NuCel with Autograft
Other
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
21 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 17, 2026, 5:15 AM EDT
Completed Not applicable Interventional

Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery

NCT03442374
View directory record Official record
Conditions
Disc Degeneration, Low Back Pain
Interventions
Exercise
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 85 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 17, 2026, 5:15 AM EDT
Completed Not applicable Interventional

Adipose Cells for Degenerative Disc Disease

NCT02097862
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Adipose Stem Cells
Procedure
Lead sponsor
Bioheart, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Sunrise, Florida
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Sep 17, 2026, 5:15 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)

NCT00947583
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 17, 2026, 5:15 AM EDT