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ClinicalTrials.gov public records Last synced Oct 2, 2026, 10:38 PM EDT

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Showing 25–48 of 173 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Dementia, Familial Clear all
Completed Not applicable Interventional Accepts healthy volunteers

CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners

NCT05187117
View directory record Official record
Conditions
Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive, Caregiver Burden, Quality of Life, Depression
Interventions
CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy

NCT01994889
View directory record Official record
Conditions
Transthyretin (TTR) Amyloid Cardiomyopathy
Interventions
Tafamidis, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 90 Years
Enrollment
441 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
50
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 24 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 2, 2026, 10:38 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

NCT01760005
View directory record Official record
Conditions
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Interventions
Gantenerumab, Solanezumab, Matching Placebo (Gantenerumab), Matching Placebo (Solanezumab), E2814, Lecanemab, Matching Placebo (E2814)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
490 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2028
U.S. locations
12
States / cities
Birmingham, Alabama • La Jolla, California • Los Angeles, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

NCT05269394
View directory record Official record
Conditions
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Interventions
E2814, Lecanemab, Matching Placebo (E2814)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
12
States / cities
Birmingham, Alabama • La Jolla, California • Los Angeles, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

NCT05776641
View directory record Official record
Conditions
Alzheimer Disease, Family Members
Interventions
GENUS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
55 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Terminated Not applicable Interventional

Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care

NCT04571502
View directory record Official record
Conditions
Neurocognitive Disorders, Alzheimer Disease, Caregiver
Interventions
My PATI ( Person Assisted Touchscreen Interface)
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 99 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Birmingham, Alabama • Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease

NCT00933608
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
memantine, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
55 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2014 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Results available

Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA

NCT04627662
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
Interventions
Tele-STELLA
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional

Coordinating Center for Enhancing ADRD Caregiving

NCT00178165
View directory record Official record
Conditions
Dementia, Alzheimer Disease
Interventions
Skill Training Condition - problem solving training, REACH for TLC (Telephone Linked Computer) system
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2001
U.S. locations
5
States / cities
Birmingham, Alabama • Menlo Park, California • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2005 · Synced Oct 2, 2026, 10:38 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Gait Analysis in Neurological Disease

NCT02994719
View directory record Official record
Conditions
Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease, Ataxia, Spinocerebellar
Interventions
Anti-Parkinson medication, Deep Brain Stimulation
Drug · Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Life Enhancing Activities for Family Caregivers (LEAF 2.0)

NCT03610698
View directory record Official record
Conditions
Caregivers
Interventions
LEAF Positive Emotion Intervention, Emotion Reporting Control Condition
Behavioral · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
386 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Results available

Pair 2 Care: Peer Support for Caregivers of Black Americans Living With Dementia

NCT06064955
View directory record Official record
Conditions
Family Caregiver, Dementia, Peer Support
Interventions
Peer Support
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobile App Psychological Interventions for Family Dementia Caregivers

NCT05253443
View directory record Official record
Conditions
Family Caregivers
Interventions
Mentalizing Imagery Therapy and caregiver skills mobile application, Caregiver skills mobile application
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.

NCT04623242
View directory record Official record
Conditions
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Interventions
Gantenerumab, Solanezumab, Matching Placebo (Gantenerumab), Matching Placebo (Solanezumab)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2020
U.S. locations
10
States / cities
Birmingham, Alabama • La Jolla, California • New Haven, Connecticut + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Telephone-delivered Mindfulness Intervention for African American Dementia Caregivers

NCT04058886
View directory record Official record
Conditions
Alzheimer Dementia, Caregiver, Dementia Alzheimers
Interventions
Telephone-delivered Mindfulness
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SAGE LEAF 2: An Online Program to Reduce Dementia Caregiver Burden

NCT06708182
View directory record Official record
Conditions
Caregiving Stress, Caregiver Burden
Interventions
SAGE LEAF Positive Emotion Skills Course
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

In-Home Care for Patients With PSP and Related Disorders

NCT03552484
View directory record Official record
Conditions
Progressive Supranuclear Palsy, Dementia With Lewy Bodies, Multiple System Atrophy, Corticobasal Syndrome, Atypical Parkinson Disease
Interventions
Home Visit Program, Usual Care/Online Survey
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
40 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Oct 2, 2026, 10:38 PM EDT
Withdrawn No phase listed Observational

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Alzheimer's Disease

NCT04100889
View directory record Official record
Conditions
Alzheimer Disease, Alzheimer Disease 1, Alzheimer Disease 2, Alzheimer Disease 3, Alzheimer Disease 4, Alzheimer Disease 5, Alzheimer Disease 6, Alzheimer Disease 7, Alzheimer Disease 8, Alzheimer Disease 9, Late-Onset, Alzheimer Disease 10, Alzheimer Disease 11, Alzheimer Disease 12, Alzheimer Disease 13, Alzheimer Disease 14, Alzheimer Disease 15, Alzheimer Disease 16, Alzheimer Disease 17, Alzheimer Disease 18, Alzheimer Disease 19, Alzheimer Disease, Early Onset, Alzheimer Disease, Late Onset, Alzheimer Disease Focal
Interventions
No Intervention
Other
Lead sponsor
ProgenaBiome
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Project ACT: Advancing Caregiving Techniques

NCT00259480
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Home Based Intervention
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
21 Years and older
Enrollment
272 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers

NCT04920006
View directory record Official record
Conditions
Dementia, Familial
Interventions
Enhancing Active Caregiver Training
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 2, 2026, 10:38 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Cooperative Huntington's Observational Research Trial

NCT00313495
View directory record Official record
Conditions
Huntington Disease
Interventions
Not listed
Lead sponsor
HP Therapeutics Foundation
Other
Eligibility
Not listed
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2020
U.S. locations
41
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 35 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2011 · Synced Oct 2, 2026, 10:38 PM EDT
Completed No phase listed Observational

F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis

NCT02414230
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
Drug: F 18 T807
Drug
Lead sponsor
Tammie L. S. Benzinger, MD, PhD
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Oct 2, 2026, 10:38 PM EDT
Completed Not applicable Interventional

REmote Assessment and Dynamic Response Intervention II

NCT04686838
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Relationship, Marital, Caregiver Stress Syndrome
Interventions
READyR II: A, READyR II: B
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Oct 2, 2026, 10:38 PM EDT
Recruiting Not applicable Interventional

Medication Collaboration Feasibility Study

NCT07742189
View directory record Official record
Conditions
Dementia Family Caregiver, Dementia, Medication Adherence
Interventions
Medication Collaboration Intervention
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 2, 2026, 10:38 PM EDT