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ClinicalTrials.gov public records Last synced Oct 28, 2026, 5:07 AM EDT

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Showing 529–552 of 3,004 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Dementia Clear all
Completed Not applicable Interventional

Orexin and Tau Pathology in Cognitively Normal Elderly

NCT03053908
View directory record Official record
Conditions
Elderly, Alzheimer Disease
Interventions
Actigraphy, Nocturnal Polysomnograpahy (NPSG)
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
55 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 28, 2026, 5:07 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Locus Coeruleus, Norepinephrine and Cognitive Aging

NCT06880510
View directory record Official record
Conditions
Alzheimer Disease
Interventions
t-VNS transcutaneous auricular vagus nerve stimulator
Device
Lead sponsor
Cornell University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

NCT01738568
View directory record Official record
Conditions
Dementia
Interventions
High intensity aerobic training, Sedentary Control
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 30, 2021 · Synced Oct 28, 2026, 5:07 AM EDT
Completed No phase listed Observational

Daily Study of Caregiving Relationships and Health

NCT04682535
View directory record Official record
Conditions
Caregiver Burnout, Dementia, Dementia of Alzheimer Type, Relations, Family, Social Stress, Relation, Interpersonal, Loneliness
Interventions
Social relationships
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
37 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2022 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementation of the Care Ecosystem Training Model for Individuals With Dementia in a High-risk, Integrated Care Management

NCT04556097
View directory record Official record
Conditions
Dementia, Alzheimer Disease
Interventions
Care Ecosystem
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
65 Years and older
Enrollment
524 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Oct 28, 2026, 5:07 AM EDT
Terminated Not applicable Interventional

The Dementia Symptom Management at Home Program Hospice Edition

NCT03352791
View directory record Official record
Conditions
Dementia
Interventions
DSM-H Hospice Edition performance improvement program, Usual Care
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 28, 2026, 5:07 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

An Innovative Platform for Objective Monitoring of Instrumental Activities of Daily Living

NCT05703490
View directory record Official record
Conditions
Dementia, Cognitive Impairment, Alzheimer Disease
Interventions
IADLSys system
Diagnostic Test
Lead sponsor
Bijan Najafi, PhD
Other
Eligibility
50 Years to 95 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Oct 28, 2026, 5:07 AM EDT
Recruiting No phase listed Observational

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

NCT06052397
View directory record Official record
Conditions
Delirium, Postoperative, Cognitive Decline, Dementia
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
70 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 28, 2026, 5:07 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Tau Tracer Comparison in Healthy Controls and Alzheimer's Disease Patients

NCT03939780
View directory record Official record
Conditions
Healthy, Alzheimer Disease
Interventions
[F18]RO-948, [F18]MK-6240, [F18]AV1451
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 100 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Development of An Exergame for Caregivers of Individuals With Alzheimer's Disease or Related Dementias

NCT03124550
View directory record Official record
Conditions
Sedentary Lifestyle, Stress, Psychological
Interventions
Exergame Experience
Behavioral
Lead sponsor
Brandeis University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 28, 2026, 5:07 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

PET Changes in Alzheimer's Disease (AD)

NCT00094913
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
20 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2009 · Synced Oct 28, 2026, 5:07 AM EDT
Terminated Phase 3 Interventional Results available

A Study to Evaluate the Safety and Tolerability of Long-term Administration of Gantenerumab in Participants With Alzheimer's Disease (AD)

NCT04339413
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Gantenerumab
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
Not listed
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
11
States / cities
Sun City, Arizona • Sherman Oaks, California • Orlando, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Phase 4 Interventional

Escitalopram Treatment of Patients With Agitated Dementia

NCT00260624
View directory record Official record
Conditions
Alzheimer's Disease, Psychomotor Agitation
Interventions
Escitalopram (Lexapro)
Drug
Lead sponsor
University of Rochester
Other
Eligibility
61 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
3
States / cities
Fairport, New York • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2012 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep, Aging and Risk for Alzheimer's Disease

NCT01962779
View directory record Official record
Conditions
Sleep Disordered Breathing, Alzheimer's Disease
Interventions
Continuous positive airway pressure (CPAP)
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
50 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2020 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Phase 2 Interventional Results available

Daridorexant to Prevent Delirium After Heart Surgery

NCT06630390
View directory record Official record
Conditions
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Interventions
Daridorexant 50 mg, Placebo
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 28, 2026, 5:07 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Evaluation of [123I] MNI-340 and SPECT as a Marker of Beta-Amyloid Protein Deposition

NCT00968097
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
123-I MNI-340
Drug
Lead sponsor
Institute for Neurodegenerative Disorders
Other
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Oct 28, 2026, 5:07 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Study of Tau Imaging With the Use of [18F]MK-6240 Tracer

NCT04104659
View directory record Official record
Conditions
Alzheimer Disease
Interventions
MK 6240
Drug
Lead sponsor
Tammie L. S. Benzinger, MD, PhD
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional Results available

Home Evaluation of Exit Barriers in Wandering

NCT00997425
View directory record Official record
Conditions
Dementia, Alzheimer Type, Problem Behavior
Interventions
Door cover/Floor cover
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
60 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 21, 2014 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Phase 1 Interventional

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B

NCT03787758
View directory record Official record
Conditions
Huntington Disease
Interventions
SAGE-718
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
2
States / cities
Long Beach, California • Marlton, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional

Effects of Aerobic Exercise for Treating Alzheimer's Disease

NCT01954550
View directory record Official record
Conditions
Alzheimer's Disease, Late Onset
Interventions
Cycling exercise, Range of motion/stretching exercise
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
66 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2022 · Synced Oct 28, 2026, 5:07 AM EDT
Active, not recruiting Not applicable Interventional

Cognitive Screening Made Easy for PCPs - R33 Phase

NCT06162026
View directory record Official record
Conditions
Cognitive Impairment, Dementia, Mild, Cognitive Decline
Interventions
RACS app
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
60 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 28, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living

NCT03383289
View directory record Official record
Conditions
Assisted Living, Resident to Resident Elder Mistreatment
Interventions
R-REM training
Other
Lead sponsor
Hebrew Home at Riverdale
Other
Eligibility
Not listed
Enrollment
930 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 28, 2026, 5:07 AM EDT
Recruiting Not applicable Interventional

The Volunteering-in-Place Program for Apathetic Assisted Living Residents With ADRD

NCT06735950
View directory record Official record
Conditions
Apathy in Dementia
Interventions
Volunteering in Place Program, Recreational activity
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
55 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Catonsville, Maryland • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 28, 2026, 5:07 AM EDT
Completed No phase listed Observational

HD-Charge: Indirect and Out-of-Pocket Costs of Huntington's Disease in the United States

NCT03628235
View directory record Official record
Conditions
Huntington's Disease
Interventions
Online survey
Behavioral
Lead sponsor
CHDI Foundation, Inc.
Other
Eligibility
21 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
11
States / cities
Phoenix, Arizona • Englewood, Colorado • Tampa, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 28, 2026, 5:07 AM EDT