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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dentin Sensitivity Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Clinical Evaluation of OBU When Used for Indirect Dental Restorations

NCT06002880
View directory record Official record
Conditions
Sensitivity, Tooth
Interventions
Optibond Universal
Device
Lead sponsor
Kerr Corporation
Industry
Eligibility
18 Years to 100 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 11, 2024 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study of Two Dentinal Hypersensitivity Treatments Used With Normal Oral Hygiene

NCT02221349
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium oxalate, Sodium fluoride paste, Stannous fluoride paste
Device · Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2020 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NUPRO Sensodyne Prophylaxis Paste With NovaMin Sensitivity Relief Study

NCT01669785
View directory record Official record
Conditions
Tooth Hypersensitivity
Interventions
Group C, Group A, Group B
Device
Lead sponsor
Dentsply International
Industry
Eligibility
18 Years to 70 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effectiveness of Two Water-Based Potassium Oxalate Desensitizers

NCT02192307
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium oxalate
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Evaluation of the Efficacy of Oral-B New Product Sensi-Stop on Dentinal Hypersensitivity

NCT02476032
View directory record Official record
Conditions
Tooth Sensitivity
Interventions
Prof applied oxalate, Self applied oxalate, Prof applied placebo
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 22, 2017 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The Efficacy of a Toothpaste to Reduce Sensitivity

NCT00763269
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Triclosan, Silicon dioxide, fluoride, Triclosan, fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
12 Years to 80 Years
Enrollment
626 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 6, 2012 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Pilot Study to Assess Nominal Versus Controlled Stimuli on Dentinal Hypersensitivity

NCT02406573
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Crest® Sensi-Stop™ Strips
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Mason, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Jun 10, 2026, 10:34 AM EDT
Recruiting No phase listed Observational

Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.

NCT07195357
View directory record Official record
Conditions
Dentin Hypersensitivity, Erosive Tooth Wear
Interventions
epidemiological
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
2,500 participants
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 10, 2026, 10:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity

NCT04005417
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
1,036 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Results available

A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device

NCT01345292
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity

NCT01592851
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 2, 2014 · Synced Jun 10, 2026, 10:34 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice

NCT07215767
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Stannous fluoride and Potassium nitrate Dentifrice, Stannous fluoride Dentifrice, Potassium nitrate Dentifrice, Vehicle Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
12 Years to 65 Years
Enrollment
850 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Melbourne, Florida • Fort Wayne, Indiana • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity

NCT01115452
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
5% Potassium nitrate, 2.5% Potassium nitrate, Sterile water
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Jun 10, 2026, 10:34 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Real-World Study of a Calcium Sodium Phosphosilicate Anti-Sensitivity Toothpaste for Dentin Hypersensitivity Relief

NCT07300540
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Calcium sodium phosphosilicate (CSPS) Toothpaste
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.

NCT02651467
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5), Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Jun 10, 2026, 10:34 AM EDT
Not yet recruiting Not applicable Interventional

Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage

NCT07590960
View directory record Official record
Conditions
Gingival Recession, Mucogingival Deformity - Insufficient Keratinized Tissue
Interventions
Modified Coronally Advanced Tunnel with Connective Tissue Graft
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jun 10, 2026, 10:34 AM EDT
Enrolling by invitation Not applicable Interventional

Using Calcium Hydroxylapatite To Treat Gum Recession and Tooth Hypersensitivity

NCT06826391
View directory record Official record
Conditions
Gingival Recession, Generalized, Gingival Recession Generalized Moderate, Gingival Recession Localized Moderate, Tooth Sensitivity
Interventions
Calcium hydroxylapatite
Device
Lead sponsor
American Academy of Facial Esthetics
Network
Eligibility
20 Years to 70 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
South Euclid, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

NCT02832375
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
stannous fluoride, sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study to Assess Efficacy of an Experimental Oral Rinse in Providing Long Term Relief From Dentinal Hypersensitivity

NCT03238352
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium oxalate, Sodium fluoride, Placebo
Device · Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes

NCT07297732
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Test Toothpaste 1, Test Toothpaste 2, Reference Toothpaste
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jun 10, 2026, 10:34 AM EDT
Completed Not applicable Interventional Results available

A Real-World Evidence Study to Evaluate Oral Health Related Quality of Life Using an Anti-Sensitivity Toothpaste

NCT04964063
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium Nitrate + Sodium Fluoride
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
655 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2024 · Synced Jun 10, 2026, 10:34 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety Assessment of Experimental Bleaching Agents

NCT06802614
View directory record Official record
Conditions
Tooth Discoloration, Dentin Sensitivity, Patient Satisfaction
Interventions
BLEACHING GEL A, 5% NF_TiO2, BLEACHING GEL B, VISIBLE LIGHT IRRADIATION, Whiteness HP 35%, Whiteness HP Automixx 6%
Device · Radiation
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Jun 10, 2026, 10:34 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Lesion Progression After Icon Treatment in Young Adults

NCT01988337
View directory record Official record
Conditions
Caries, Salivary Function, Tooth Sensitivity
Interventions
Resin infiltration, Mock treatment
Device · Other
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
19 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Jun 10, 2026, 10:34 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

A Study Evaluating Oral-Health-Related Quality of Life and Treatment Patterns Among Dentin Hypersensitivity Sufferers

NCT07337109
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Not listed
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jun 10, 2026, 10:34 AM EDT