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ClinicalTrials.gov public records Last synced Oct 29, 2026, 1:10 AM EDT

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Showing 25–48 of 4,835 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depressed Clear all
Completed Not applicable Interventional Results available

Evaluation of a Mobile Therapy for Elevated Depressive Symptoms

NCT04463914
View directory record Official record
Conditions
Depressive Symptoms, Depression
Interventions
Behavioral Activation Therapy app, Behavioral Activation Therapy app + EHR, Treatment as Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
649 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)

NCT02942004
View directory record Official record
Conditions
Postpartum Depression
Interventions
Placebo, SAGE-547 60 μg/kg/h, SAGE-547 90 μg/kg/h
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
32
States / cities
Chandler, Arizona • Rogers, Arkansas • Lemon Grove, California + 27 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Center M: Digital Health Innovation Pilot

NCT06000449
View directory record Official record
Conditions
Perinatal Depression
Interventions
Center M, Treatment as Usual
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

MOMCare: Culturally Relevant Treatment Services for Perinatal Depression

NCT01045655
View directory record Official record
Conditions
Depression
Interventions
MOMCare
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 15, 2016 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)

NCT04607226
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
24 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Phase 4 Interventional Results available

Antidepressant Treatment of Melancholia in Late Life

NCT00000378
View directory record Official record
Conditions
Depression, Melancholia
Interventions
Sertraline, Nortriptyline
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 95 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Oct 29, 2026, 1:10 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Study to Evaluate the Effectiveness of Certain Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants During Pregnancy and Evaluate Newborn Outcomes

NCT00553917
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings

NCT00974402
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Stress Disorders, Combat Disorders
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2014 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional Results available

Bright Start Study

NCT05356130
View directory record Official record
Conditions
Depression
Interventions
Written Educational Material on BLT, Enhanced BLT Encouragement and Adherence Promotion
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 69 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

REstoring Mental Health Through COmmUnity-based Psychological Services in New York City

NCT04913766
View directory record Official record
Conditions
Depression, Anxiety, Psychological Distress, PTSD
Interventions
Problem Management Plus, Services as Usual
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
1,206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

NCT05697172
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Phase 1 Interventional Results available

Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors

NCT02950467
View directory record Official record
Conditions
Distress, Depression, Grief
Interventions
Psilocybin, Modified brief Supportive Expressive Group Therapy
Drug · Behavioral
Lead sponsor
Joshua Woolley
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Oct 29, 2026, 1:10 AM EDT
Terminated Early Phase 1 Interventional Results available

Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers

NCT06001372
View directory record Official record
Conditions
Gastrointestinal Cancer, Depression, Anxiety
Interventions
Ketamine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Recruiting Early Phase 1 Interventional

Confirmatory Efficacy Trial of Attention Bias Modification for Depression

NCT06361095
View directory record Official record
Conditions
Depression
Interventions
Traditional Attention Bias Modification, Gamified Attention Bias Modification, Sham Attention Bias Modification
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 70 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Phase 2Phase 3 Interventional

Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression

NCT01528839
View directory record Official record
Conditions
Bipolar Disorder
Interventions
L-Thyroxine, Placebo
Drug
Lead sponsor
Charite University, Berlin, Germany
Other
Eligibility
18 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2012 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Brief Peer Supported webSTAIR Compared to Enhanced Wait List

NCT04286165
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Depression, Emotion Regulation
Interventions
Brief Peer Supported webSTAIR
Other
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
21 Years to 80 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2023 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Perinatal Depression Treatment in a Pediatric Setting- Pilot Phase

NCT00804739
View directory record Official record
Conditions
Postpartum Depression
Interventions
Mother-Infant Treatment Team
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2012 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Light Treatment During Sleep on Young Men

NCT00796939
View directory record Official record
Conditions
Depression
Interventions
Green light mask, Red Light Mask
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
25 Years to 60 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2015 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional Results available

Behavior, Biology and Well-Being Study

NCT06213701
View directory record Official record
Conditions
Depression, Psychological Distress
Interventions
Healthy Minds Program, Psychoeducation app
Device · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Can Rumination-Focused Cognitive Behavioral Therapy Reduce the Risk of Cardio-vascular Disease?

NCT05980130
View directory record Official record
Conditions
Rumination, Depressive Symptoms, Blood Pressure
Interventions
Rumination-Focused Cognitive Behavior Therapy
Behavioral
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Not applicable Interventional

A Novel Person-Centered Treatment Component for Substance Use Treatment

NCT02005367
View directory record Official record
Conditions
Substance Use Disorders, Depression, Bipolar Disorder, Psychosis, Personality Disorders
Interventions
Natural Recovery-Horticulture, Natural Recovery-Art/Music
Behavioral
Lead sponsor
Hampton VA Medical Center
Federal
Eligibility
18 Years to 85 Years
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Hampton, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2013 · Synced Oct 29, 2026, 1:10 AM EDT
Completed Phase 2 Interventional Results available

Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD

NCT03051256
View directory record Official record
Conditions
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant
Interventions
REL-1017, Placebo
Drug
Lead sponsor
Relmada Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
10
States / cities
Little Rock, Arkansas • Garden Grove, California • San Diego, California + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Oct 29, 2026, 1:10 AM EDT
Completed No phase listed Observational

Social Media Connectedness in Fibromyalgia

NCT07715877
View directory record Official record
Conditions
Fibromyalgia (FM), Social Connection, Suicidal Thoughts
Interventions
Social Media
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
1,041 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 29, 2026, 1:10 AM EDT
Completed No phase listed Observational

Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)

NCT00001657
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 29, 2026, 1:10 AM EDT