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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional Results available

Efficacy and Tolerability of Riluzole in Treatment Resistant Depression

NCT01204918
View directory record Official record
Conditions
Depression
Interventions
Riluzole, placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
3
States / cities
New Haven, Connecticut • Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Sep 4, 2026, 7:55 AM EDT
Recruiting Phase 3 Interventional

Biomarker-guided rTMS for Treatment Resistant Depression

NCT04041479
View directory record Official record
Conditions
Treatment Resistant Depression, Major Depressive Disorder
Interventions
Repetitive Transcranial Magnetic Stimulation
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
22 Years to 65 Years
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Stanford, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Implementation Science Approach to Enhancing Depression Treatment in Collaborative Depression Care Settings ( DepCare )

NCT05085886
View directory record Official record
Conditions
Depressive Symptoms
Interventions
DepCare, Enhanced Usual Care
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
605 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Sep 4, 2026, 7:55 AM EDT
Recruiting Phase 2 Interventional

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT06511908
View directory record Official record
Conditions
Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action, Neurotransmitter Agents, Excitatory Amino Acid Agents, Physiological Effects of Drugs, Depressive Disorder, Major, Depressive Disorder, Depression, Mental Disorders, Mood Disorders, Behavioral Symptoms
Interventions
(2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg), Placebo
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Phase 2 Interventional Results available

Neurosteroids for Treatment of PTSD in Veterans

NCT03799562
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Pregnenolone, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Cognitive Training for Depression II

NCT01934491
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cognitive Training A, Cognitive Training B
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Project UPLIFT for Psychogenic Non-Epileptic Seizures

NCT03329703
View directory record Official record
Conditions
Psychogenic Non-Epileptic Seizure, Depression, Non-Epileptic Seizure, Psychogenic Seizure
Interventions
Project UPLIFT
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Collaborative Care for Depression and Diabetic Retinopathy in African Americans

NCT02121340
View directory record Official record
Conditions
Diabetic Retinopathy
Interventions
Behavioral Activation
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
65 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 20, 2019 · Synced Sep 4, 2026, 7:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Social Needs Screening and Chronic Diseases Study (WE CARE)

NCT06903897
View directory record Official record
Conditions
Hyperlipidemias, Diabetes, Depression, Pediatric Asthma, Hypertension
Interventions
WE CARE SDOH System, Standard Pediatric Care
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
Not listed
Enrollment
68,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
3
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Phase 2 Interventional Results available

Omega-3 Fatty Acids in Adolescent Depression

NCT00312897
View directory record Official record
Conditions
Adolescent Depression
Interventions
Omega-3 Fatty Acids, corn oil
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 19 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 18, 2018 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Mindful Movement Program in Improving Quality of Life in Older Female Breast Cancer Survivors

NCT00903474
View directory record Official record
Conditions
Anxiety Disorder, Breast Cancer, Cancer Survivor, Cognitive/Functional Effects, Depression, Psychosocial Effects of Cancer and Its Treatment
Interventions
questionnaire administration, study of socioeconomic and demographic variables, CAM exercise therapy, psychosocial assessment and care, quality-of-life assessment, stress management therapy
Other · Procedure
Lead sponsor
City of Hope Medical Center
Other
Eligibility
50 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Sep 4, 2026, 7:55 AM EDT
Recruiting No phase listed Observational

A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy

NCT07047820
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Zuranolone
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Woonsocket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Phase 2 Interventional

Mechanistic Evaluation of Response in TRD (MERIT)

NCT04608396
View directory record Official record
Conditions
Treatment Resistant Depression, Major Depressive Disorder
Interventions
AXS-05, Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
20
States / cities
Little Rock, Arkansas • Redlands, California • Sherman Oaks, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2022 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Phase 3 Interventional

Comparing Delivery Methods of Cognitive Behavioral Therapy for Depressed African-American Dementia Caregivers

NCT00769769
View directory record Official record
Conditions
Depression
Interventions
Psychotherapy
Behavioral
Lead sponsor
Robert L. Glueckauf
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 22, 2013 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Meditation for Dementia Caregivers Major Depressive Disorder in Family Dementia Caregivers

NCT02122068
View directory record Official record
Conditions
Mentalizing Imagery Therapy, Relaxation Recording
Interventions
Mentalizing Imagery Therapy, Relaxation cd
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
45 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Phase 2 Interventional Results available

Decreasing Risk of Coronary Artery Disease in Schizophrenia by Omega-3 Fatty Acid Supplementation

NCT00167310
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Major Depression, Bipolar Disorder, Coronary Artery Disease
Interventions
Eicosapentaenoic acid (omega-3 fatty acid), Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2017 · Synced Sep 4, 2026, 7:55 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Assessing the Impact of VR-Based Observational Mindfulness Meditation on Stress Reduction in Adults

NCT06704282
View directory record Official record
Conditions
Stress, Anxiety, Depression
Interventions
VR Mindfulness Meditation Program
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Sep 4, 2026, 7:55 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

ENA-001 for Opioid Induced Respiratory Depression

NCT06967259
View directory record Official record
Conditions
Respiratory Depression
Interventions
ENA-001, Placebo Comparator
Drug
Lead sponsor
Enalare Therapeutics Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Miami, Florida • Overland Park, Kansas • Eatontown, New Jersey
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intern Health Study 2024

NCT06465680
View directory record Official record
Conditions
Depression, Mood, Sleep, Physical Activity
Interventions
Intern Health Study behavioral change mobile notification
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,047 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrated Model for Promoting Parenting and Early School Readiness in Pediatrics

NCT02459327
View directory record Official record
Conditions
Infant Behavior, Child Behavior, Parenting, Child Rearing, Depression, Personal Satisfaction, Behavioral Symptoms, Social Control, Informal
Interventions
Video Interaction Project, Family Check Up
Behavioral
Lead sponsor
New York University
Other
Eligibility
0 Years and older
Enrollment
403 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
2
States / cities
New York, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Sep 4, 2026, 7:55 AM EDT
Not listed Not applicable Interventional

Homecare Agency-Randomized Trial of Web Implementation Strategy for Depression

NCT02206386
View directory record Official record
Conditions
Depression
Interventions
MHTraining-Net, Enhanced Support
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
7,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Sep 4, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

Berries, Bugs, and the Blues

NCT05817383
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Freeze-dried Blueberry Powder, Placebo Powder
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 4, 2026, 7:55 AM EDT
Terminated Not applicable Interventional

Effects of Backward Gait Training With Exoskeleton on Motor Functions

NCT05133362
View directory record Official record
Conditions
Gait, Hemiplegic, Physical Therapy
Interventions
Gait training with EksoNR, Backward gait training with EksoNR
Device · Procedure
Lead sponsor
Alvernia University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Schenectady, New York • Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 4, 2026, 7:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Remote Physiologic Monitoring of Resident Wellness and Burnout

NCT04304703
View directory record Official record
Conditions
Resident Wellness, Resident Burnout, Sleep, Stress, Anxiety, Depression
Interventions
WHOOP strap 3.0
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Sep 4, 2026, 7:55 AM EDT