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ClinicalTrials.gov public records Last synced Nov 5, 2026, 9:18 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 961–984 of 4,844 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Treatment Resistant Depression
Interventions: Active study drug ( oral CBD), matching placebo; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Depression, Anxiety, Healthy, Mental Health Wellness 1
Interventions: Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale; Diagnostic Test
Lead sponsor: Kintsugi Mindful Wellness, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 19,533 participants
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Depression, Adverse Effects
Interventions: Genocept Assay; Genetic
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depression, Anxiety
Interventions: Supporting Our Valued Adolescents (SOVA), Enhanced Usual Care; Behavioral · Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years to 19 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: Omega-3 supplement, Placebo; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 25 Years and older
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Depressive Symptoms, Inflammation
Interventions: Pleasant Events Program (PEP), Information Support (IS); Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 55 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Cancer, Major Depressive Disorder
Interventions: Psilocybin, Placebo; Drug
Lead sponsor: Sunstone Medical; Other
Eligibility: 18 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Rockville, Maryland

Conditions: Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression, Alcohol Abuse, Drinking, College, Alcohol Drinking, Alcohol; Harmful Use, Social Stigma, Social Norms, Social Responsibility, Social Behavior, Empathy, Coping Skills, Coping Behavior
Interventions: Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS); Behavioral
Lead sponsor: University of New Hampshire; Other
Eligibility: 18 Years to 24 Years
Enrollment: 1,268 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, New Hampshire

Conditions: Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
Interventions: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cystic Fibrosis
Interventions: Yoga treatment program; Other
Lead sponsor: Children's Hospitals and Clinics of Minnesota; Other
Eligibility: 9 Years to 18 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Dyspepsia, Gastroparesis, Anxiety, Depression
Interventions: Poetry, Poetry Manual; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Mild Cognitive Impairment
Interventions: Problem Solving Therapy, Problem Solving Therapy + Exercise, Enhanced Usual Care; Behavioral · Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 60 Years and older
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Multiple Sclerosis, Major Depressive Disorder
Interventions: POWER-MS, FLEX-MS; Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years to 64 Years
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depression, Anxiety, Adolescent Behavior, Stress
Interventions: Trauma-Informed Yoga; Behavioral
Lead sponsor: Montana State University; Other
Eligibility: 11 Years to 18 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Livingston, Montana

Conditions: Major Depressive Disorder
Interventions: Standard Quality Improvement, Patient-centered Intervention; Procedure
Lead sponsor: Agency for Healthcare Research and Quality (AHRQ); Federal
Eligibility: 18 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 5
States / cities: Wilmington, Delaware • Baltimore, Maryland

Conditions: Depression
Interventions: Computer Assisted Education for Behavior Change; Behavioral
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alcohol; Use, Problem, Stress, Binge Eating, Depression
Interventions: behavioral activation; Behavioral
Lead sponsor: University of Kansas; Other
Eligibility: 17 Years and older
Enrollment: 572 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Lawrence, Kansas

Conditions: Major Depressive Disorder
Interventions: Not listed
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2020
U.S. locations: 3
States / cities: Irvine, California • Stanford, California • New York, New York

Conditions: Mental Health, Neurology, Health Services
Interventions: self management of PSD symptoms, screening and treatment of PSD; Behavioral · Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Gainesville, Florida • Indianapolis, Indiana

Conditions: Depression, Major Depressive Disorder, Postpartum Depression
Interventions: Triple Chronotherapy, Usual Care; Behavioral · Other
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Inflammation, Depression Disorder, Mindfulness, Emotional Well-being, Physical Health, Mental Health
Interventions: Mindfulness-based cognitive therapy for perinatal depression, Pregnancy Health Group; Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Major Depressive Disorder, Depression
Interventions: TC-5214, Placebo; Drug
Lead sponsor: AstraZeneca; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 2,409 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 79
States / cities: Birmingham, Alabama • Tucson, Arizona • Conway, Arkansas + 76 more

Conditions: Depressive Disorder, Major, Menopause
Interventions: Estrogen; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2004
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression, Chronic Pain, Substance Abuse
Interventions: co-administration of TMS and infused ketamine; Other
Lead sponsor: The Neuroscience Center, LLC; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Deerfield, Illinois

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Cannabidiol for Treatment Resistant Depression

Voice Biomarkers Predictive of Depression and Anxiety

Genecept Assay and Adverse Effects of Antidepressants

Supporting Our Valued Adolescents Pilot Randomized Controlled Trial

Omega-3 for Depression and Other Cardiac Risk Factors - 2

Reducing CVD Risk in Caregivers: A Brief Behavioral Activation Intervention

Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer

Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking

The Pitt Center for Emergency Responder Wellness

Treatment of Anxiety/Depression and Pain Through Relaxation Yoga for Patient With Cystic Fibrosis (CF)

Virtual Poetry Workshops to Enhance Patient Well Being and Reduce Anxiety

Retaining Cognition While Avoiding Late-Life Depression

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

A Trauma-Informed Approach for Positive Youth Development for Montana Students

Patient-Centered Depression Care for African Americans

Automated Telephone System to Improve Treatment Adherence in People With Depression

A Behavioral Activation Intervention Administered in a College Freshman Orientation Course

Identifying Biological Markers for Severe Depression

Implementing Evidence in the Detection and Treatment of Post Stroke Depression

Integrated Chronotherapy for Perinatal Depression

Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health

A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder

Estrogen and Perimenopausal Depression

Neuromodulation to Facilitate the Effect of Ketamine