A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder
Public ClinicalTrials.gov record NCT01153347. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind Parallel Group Placebo-Controlled Phase III,Efficacy and Safety Study of 3 Fixed Dose Groups of TC-5214 (S-mecamylamine) as an Adjunct to an Antidepressant in Patients With Major Depressive Disorder Who Exhibit an Inadequate Response to Antidepressant Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like medicine tablet or capsule, but contains no active medicine) is safe and effective when taken together with another antidepressant.
Study identification
- NCT ID
- NCT01153347
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,409 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2010 (Type not available)
- Primary completion
- Jan 2012 (Actual)
- Completion
- Jan 2012 (Actual)
- Last update posted
- Apr 11, 2014
2010 – 2012
United States locations
- U.S. sites
- 79
- U.S. states
- 30
- U.S. cities
- 79
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | — | — |
| Research Site | Tucson | Arizona | — | — |
| Research Site | Conway | Arkansas | — | — |
| Research Site | Little Rock | Arkansas | — | — |
| Research Site | Arcadia | California | — | — |
| Research Site | Beverly Hills | California | — | — |
| Research Site | Garden Grove | California | — | — |
| Research Site | Los Angeles | California | — | — |
| Research Site | Newport Beach | California | — | — |
| Research Site | Oakland | California | — | — |
| Research Site | Oceanside | California | — | — |
| Research Site | Pico Rivera | California | — | — |
| Research Site | Santa Ana | California | — | — |
| Research Site | Upland | California | — | — |
| Research Site | Denver | Colorado | — | — |
| Research Site | Cromwell | Connecticut | — | — |
| Research Site | New London | Connecticut | — | — |
| Research Site | Norwich | Connecticut | — | — |
| Research Site | Washington D.C. | District of Columbia | — | — |
| Research Site | Bradenton | Florida | — | — |
| Research Site | Fort Myers | Florida | — | — |
| Research Site | Fort Walton Beach | Florida | — | — |
| Research Site | Gainsville | Florida | — | — |
| Research Site | Jacksonville | Florida | — | — |
| Research Site | North Miami | Florida | — | — |
| Research Site | Orlando | Florida | — | — |
| Research Site | Plantation | Florida | — | — |
| Research Site | South Miami | Florida | — | — |
| Research Site | St. Petersburg | Florida | — | — |
| Research Site | Tampa | Florida | — | — |
| Research Site | West Palm Beach | Florida | — | — |
| Research Site | Atlanta | Georgia | — | — |
| Research Site | Roswell | Georgia | — | — |
| Research Site | Hoffman Estates | Illinois | — | — |
| Research Site | Joliet | Illinois | — | — |
| Research Site | Schaumburg | Illinois | — | — |
| Research Site | Skokie | Illinois | — | — |
| Research Site | Valparaiso | Indiana | — | — |
| Research Site | Prairie Village | Kansas | — | — |
| Research Site | Wichita | Kansas | — | — |
| Research Site | Florence | Kentucky | — | — |
| Research Site | Baltimore | Maryland | — | — |
| Research Site | Gaithersburg | Maryland | — | — |
| Research Site | Boston | Massachusetts | — | — |
| Research Site | Weymouth | Massachusetts | — | — |
| Research Site | Flowood | Mississippi | — | — |
| Research Site | St Louis | Missouri | — | — |
| Research Site | North Platte | Nebraska | — | — |
| Research Site | Toms River | New Jersey | — | — |
| Research Site | Willingboro | New Jersey | — | — |
| Research Site | Mount Kisco | New York | — | — |
| Research Site | New York | New York | — | — |
| Research Site | Rochester | New York | — | — |
| Research Site | Staten Island | New York | — | — |
| Research Site | Avon Lake | Ohio | — | — |
| Research Site | Beachwood | Ohio | — | — |
| Research Site | Beechwood | Ohio | — | — |
| Research Site | Cincinnati | Ohio | — | — |
| Research Site | Mason | Ohio | — | — |
| Research Site | Oklahoma City | Oklahoma | — | — |
| Research Site | Portland | Oregon | — | — |
| Research Site | Allentown | Pennsylvania | — | — |
| Research Site | Norristown | Pennsylvania | — | — |
| Research Site | Pittsburgh | Pennsylvania | — | — |
| Research Site | Sellersvillle | Pennsylvania | — | — |
| Research Site | Lincoln | Rhode Island | — | — |
| Research Site | Charleston | South Carolina | — | — |
| Research Site | Memphis | Tennessee | — | — |
| Research Site | Austin | Texas | — | — |
| Research Site | Dallas | Texas | — | — |
| Research Site | Irving | Texas | — | — |
| Research Site | San Antonio | Texas | — | — |
| Research Site | Sugar Land | Texas | — | — |
| Research Site | Murray | Utah | — | — |
| Research Site | Bellevue | Washington | — | — |
| Research Site | Bothell | Washington | — | — |
| Research Site | Seattle | Washington | — | — |
| Research Site | South Kirkland | Washington | — | — |
| Research Site | Spokane | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01153347, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 11, 2014 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01153347 live on ClinicalTrials.gov.