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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:26 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1489–1512 of 4,844 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Depression, Depressive Disorder, Depression, Postpartum, Behavioral Symptoms, Mood Disorders, Mental Disorders, Puerperal Disorders, Pregnancy Complications, Postpartum, PPD
Interventions: Ganaxolone, Placebo; Drug
Lead sponsor: Marinus Pharmaceuticals; Industry
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 16
States / cities: Little Rock, Arkansas • Costa Mesa, California • Lemon Grove, California + 13 more

Conditions: Major Depressive Disorder
Interventions: Group IPT for Depression + TAU; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 5
States / cities: Bridgewater, Massachusetts • Framingham, Massachusetts • Norfolk, Massachusetts + 1 more

Conditions: Depression, Involutional
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Depression, Subclinical Depressive Symptoms
Interventions: Computerized cognitive training (CCT) using EndeavorRx; Device
Lead sponsor: University of Michigan; Other
Eligibility: 9 Years to 17 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury, Headache, Dizziness, Cognitive Symptom, Dysautonomia, Anxiety, Irritability; Syndrome, Depression, Post-traumatic Stress Disorder
Interventions: Active cTBS, Inactive/Sham cTBS, Imaginal exposure; Device · Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Westwood, Los Angeles, California

Conditions: MDD
Interventions: CM-PST, SG-PST; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 60 Years and older
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: Sonora, California

Conditions: PostPartum Depression
Interventions: MamaLift Plus, Digital Sham App; Device
Lead sponsor: Healthcare Innovation Technology Lab; Industry
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 142 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression
Interventions: Memantine HCL; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Depression
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 283 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2009
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cancer
Interventions: Project Onward website + social network, Project Onward website; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 19 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Aging, Physical Dependence
Interventions: VIPA and companion booklet; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 65 Years and older
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Head and Neck Cancer, Pancreatic Cancer, Depression
Interventions: Ketamine, Placebo; Drug · Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression
Interventions: Lexapro, Light touch, Massage; Drug · Behavioral
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Major Depressive Disorder
Interventions: XEN1101 10 mg, XEN1101 20 mg, Placebo; Drug
Lead sponsor: Xenon Pharmaceuticals Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 20
States / cities: Anaheim, California • Lafayette, California • Pico Rivera, California + 15 more

Conditions: Bipolar Disorder
Interventions: Ketamine hydrochloride injection, Flat tonic water (e.g., Canada Dry Tonic Water); Drug
Lead sponsor: Juvenile Bipolar Research Foundation; Other
Eligibility: 6 Years to 12 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 4
States / cities: Not Predetermined, Connecticut • Maplewood, New Jersey • Not Predetermined, New Jersey + 1 more

Conditions: Major Depressive Disorder
Interventions: L-methylfolate, Selective serotonin reuptake inhibitor (SSRI), Serotonin and norepinephrine reuptake inhibitor (SNRI); Drug
Lead sponsor: Pamlab, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 242 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Bipolar Disorder, Bipolar Depression, Depression
Interventions: ziprasidone (Geodon), placebo; Drug
Lead sponsor: Tufts Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 4
States / cities: Chicago, Illinois • Boston, Massachusetts • Cambridge, Massachusetts + 1 more

Conditions: Depression, Anxiety
Interventions: ADAPT Platform (Treatment), ADAPT Comparison (Control); Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 107 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Irvine, California

Conditions: Treatment of Depression in Adults With Parkinson's Disease (PD)
Interventions: Pimavanserin; Drug
Lead sponsor: ACADIA Pharmaceuticals Inc.; Industry
Eligibility: 50 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 21
States / cities: Costa Mesa, California • Fountain Valley, California • Pasadena, California + 18 more

Conditions: Down Syndrome, Depression
Interventions: Fluoxetine; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Lexington, Massachusetts

Conditions: Depression
Interventions: transcranial magnetic stimulation; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Obesity, Depression
Interventions: Dietary and physical activity modifications; Behavioral
Lead sponsor: University of Kentucky; Other
Eligibility: 10 Years to 14 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Pelvic Organ Prolapse
Interventions: Not listed
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Treatment-resistant Depression
Interventions: Propofol, Electroencephalography (EEG), Slow-Wave Activity; Drug · Diagnostic Test
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 60 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Search by objective public record fields.

A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression

Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression

Neurocardiac Control in Major Depression

Cognitive Training Video Game to Target Subclinical Depressive Symptoms in Youth

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

Senior Peer Alliance for Rural Research On Wellness

Curio Digital Therapy for the Treatment of Post-partum Depression

Clinical Trial of Memantine for Major Depression

Antidepressant Use During Pregnancy

E-health Intervention for Cancer Survivors

Intelligent Personal Assistant for Managing Depression in Homebound Older Adults

Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck Cancers

Combination Lexapro and Massage for Treatment of Depression in Older Adults

A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder

Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder

Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis

Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State

Evaluation of a Crowd-Powered Web Platform for Depression and Anxiety

Safety and Efficacy of Pimavanserin in Adults With Parkinson's Disease and Depression

Fluoxetine Treatment of Depression in Down Syndrome

Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

Mood and Behavior Changes Among Overweight Adolescent Females

Factors Affecting Perioperative Outcomes

Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I