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ClinicalTrials.gov public records Last synced Oct 27, 2026, 11:13 AM EDT

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Showing 313–336 of 5,331 matching trials from the live ClinicalTrials.gov search.
Conditions
Insomnia, Depressive Disorder, Major
Interventions
Eszopiclone, Placebo
Drug · Other
Lead sponsor
Sumitomo Pharma America, Inc.
Industry
Eligibility
21 Years to 64 Years
Enrollment
545 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
65
States / cities
Birmingham, Alabama • Peoria, Arizona • Tucson, Arizona + 62 more
Conditions
Depression, Anxiety
Interventions
Not listed
Lead sponsor
Assurex Health Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Chicago, Illinois
Recruiting Not applicable Interventional Accepts healthy volunteers

Support for Bereaved Cancer Caregivers

NCT06662409
Conditions
Bereavement, Cancer, Caregiver, Grief
Interventions
Nature-based healing meditation (NBHM) intervention
Other
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
East Lansing, Michigan
Conditions
Major Depressive Disorder
Interventions
Interpersonal psychotherapy for major depression following perinatal loss, Coping with Depression
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
199 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Flint, Michigan
Completed Phase 1 Interventional Results available

Lipopolysaccharide (LPS) Challenge in Depression

NCT03142919
Conditions
Major Depressive Disorder
Interventions
Lipopolysaccharide, Placebo
Biological
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Conditions
Depressive Symptoms, Hiv
Interventions
Tai chi/qigong intervention group, Health Education group
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
50 Years to 75 Years
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Miami, Florida
Conditions
Individuals at Risk for Depression
Interventions
AIM Web based intervention + surveillance, AIM web based intervention, Educational website
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
19 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Acute Cannabis-induced CNS Depression
Interventions
Not listed
Lead sponsor
Anebulo Pharmaceuticals
Industry
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Worcester, Massachusetts • Cincinnati, Ohio • Portland, Oregon
Conditions
Depression, Unipolar
Interventions
Hatha Yoga Practice Group, Attention Control Education Group
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Francisco, California
Conditions
Depression
Interventions
Venlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro), Placebo, Interpersonal Clinical Interaction (ICI)
Drug · Other · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study

NCT03427528
Conditions
Perinatal Depression, Postpartum Depression, Depression
Interventions
Fathers and Babies (FAB), MB 1-on-1 plus TXT
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Terminated Not applicable Interventional Accepts healthy volunteers

Ginger.io Behavioral Health Study

NCT02491307
Conditions
Anxiety, Depression, Bipolar I Disorder, Bipolar II Disorder
Interventions
Ginger.io Smartphone Application
Other
Lead sponsor
Community Health Center, Inc.
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
4
States / cities
Meriden, Connecticut • Middletown, Connecticut • New Britain, Connecticut + 1 more
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Imaging Dopamine Release in Depression

NCT02033369
Conditions
Major Depressive Disorder
Interventions
Pramipexole
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Recruiting Not applicable Interventional Accepts healthy volunteers

RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

NCT05977439
Conditions
Depression, Major Depressive Disorder, Suicidal Ideation
Interventions
Single-Pulse Transcranial Magnetic Stimulation, EEG-Synchronized Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Behavioral Therapy (CBT), Cognitive Flexibility and Emotion Regulation Tasks
Device · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Influenza Challenge in Mood Disorders

NCT02415166
Conditions
MAJOR DEPRESSIVE DISORDER
Interventions
INFLUENZA VACCINE, NaCl-saline placebo
Biological · Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Tulsa, Oklahoma
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Social Behavior Over the Lifespan

NCT00914953
Conditions
Social Activity
Interventions
oxytocin (Pitocin)
Drug
Lead sponsor
Claremont Graduate University
Other
Eligibility
50 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Active, not recruiting No phase listed Observational

Depression and Adherence in Head and Neck Cancer

NCT00498875
Conditions
Oropharyngeal Cancer, Head and Neck Cancer
Interventions
Questionnaire, Depression Intervention
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2026
U.S. locations
1
States / cities
Houston, Texas
Conditions
Distress, Emotional, Depression, Anxiety, Fatigue, Pain, Insomnia
Interventions
Individualized Evidence-Based Therapy in Cancer (Patients and Caregivers), Training in Individualized Evidence-Based Therapy in Cancer (Therapists)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Terminated Phase 2 Interventional Results available

Org 24448 to Treat Major Depression

NCT00113022
Conditions
Depression
Interventions
Org 24448, Placebo
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
21 Years to 70 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
2
States / cities
Bethesda, Maryland • New York, New York
Conditions
Depression
Interventions
AZD6765
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
21 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
5
States / cities
Glendale, California • Hartford, Connecticut • New Haven, Connecticut + 2 more
Conditions
Depression in Adolescence
Interventions
Trier Social Stress Test (TSST)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS, Aggression
Interventions
IGC-AD1-Active, IGC-AD1-Placebo
Drug
Lead sponsor
IGC Pharma, LLC
Industry
Eligibility
60 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
21
States / cities
Maitland, Florida • Melbourne, Florida • Miami, Florida + 15 more
Conditions
Major Depression
Interventions
Selegiline Transdermal System
Drug
Lead sponsor
Somerset Pharmaceuticals
Industry
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
15
States / cities
Chula Vista, California • San Diego, California • Upland, California + 11 more
Completed Not applicable Interventional Results available

Comprehensive vs. Assisted Management of Mood and Pain Symptoms

NCT01757301
Conditions
Pain, Depression, Anxiety, Musculoskeletal, Fibromyalgia
Interventions
Assisted Symptom Management (ASM), Comprehensive Symptom Management (CSM)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana