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ClinicalTrials.gov public records Last synced Oct 28, 2026, 12:39 AM EDT

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Showing 505–528 of 5,331 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Not yet recruiting Not applicable Interventional

Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling

NCT06748950
View directory record Official record
Conditions
Schizophrenia, Schizophrenia and Related Disorders, Bipolar Disorder, Bipolar and Related Disorders, Major Depressive Disorder, Major Depression Severe, Ketogenic Dieting, Ketosis, Metabolic Disease, Metabolic Syndrome
Interventions
LCHF Ketogenic Diet, Diet-as-Usual (DAU)
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome

NCT02421276
View directory record Official record
Conditions
Down Syndrome, Polyendocrinopathies, Autoimmune, Respiratory Tract Infections, Autoimmunity
Interventions
Phlebotomy
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 22 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Oct 28, 2026, 12:39 AM EDT
Recruiting Not applicable Interventional

Time Restricted Eating (TRE) in Bipolar Disorder

NCT07211217
View directory record Official record
Conditions
Bipolar Disorder (BD), Bipolar Disorder Depression, Overweight (BMI > 30)
Interventions
Time Restricted Eating
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Phase 4 Interventional

RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)

NCT05531591
View directory record Official record
Conditions
Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression, Major Depressive Disorder, Treatment-Refractory Depression, Late Life Depression, Geriatric Depression
Interventions
Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion, Lithium Augmentation, Switch to nortriptyline
Drug
Lead sponsor
Centre for Addiction and Mental Health
Other
Eligibility
60 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
3
States / cities
Los Angeles, California • St Louis, Missouri • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Oct 28, 2026, 12:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

NCT03336918
View directory record Official record
Conditions
Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
Interventions
Lithium
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 28, 2026, 12:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Sex Hormones on Circadian Rhythm in Men and Women

NCT00001285
View directory record Official record
Conditions
Bipolar Disorder, Circadian Rhythm, Depressive Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Female only
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1991 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline

NCT06466655
View directory record Official record
Conditions
Middle-aged Adults, Major Depressive Disorder
Interventions
MitoTempol, Lactated Ringer's (control)
Drug
Lead sponsor
University of Delaware
Other
Eligibility
40 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 28, 2026, 12:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

NCT06737055
View directory record Official record
Conditions
Sleep, Postpartum Depression, Pregnancy Related, Insomnia, Sleep Deprivation, Sleep Hygiene, Sleep Disturbance
Interventions
Education about behavioral strategies to improve sleep
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 99 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 28, 2026, 12:39 AM EDT
Suspended Phase 2 Interventional

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

NCT06705478
View directory record Official record
Conditions
Major Depressive Disorder, Mild Neurocognitive Disorder, HIV
Interventions
Pramipexole ER, Escitalopram
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 70 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
25
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Phase 4 Interventional

Paroxetine in the Treatment of Chronic Primary Insomnia

NCT00178048
View directory record Official record
Conditions
Primary Insomnia, Depression
Interventions
paroxetine
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
55 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 15, 2005 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Phase 2 Interventional Results available

Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients

NCT02466685
View directory record Official record
Conditions
Bipolar Disorder
Interventions
JNJ-18038683, Placebo
Drug
Lead sponsor
Herbert Meltzer
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2023 · Synced Oct 28, 2026, 12:39 AM EDT
Recruiting Not applicable Interventional

DBS for TRD With the Medtronic Percept PC

NCT05773755
View directory record Official record
Conditions
Major Depressive Disorder, Treatment Resistant Depression
Interventions
Medtronic Percept PC DBS system
Device
Lead sponsor
Helen Mayberg, MD
Other
Eligibility
25 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 28, 2026, 12:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Dopamine Neurotransmission in Major Depression

NCT01659814
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2014 · Synced Oct 28, 2026, 12:39 AM EDT
Completed No phase listed Observational

Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence

NCT01528748
View directory record Official record
Conditions
Depressive Disorder, Major Depressive Disorder, Dysthymic Disorder, Alcohol-Related Disorders, Alcoholism
Interventions
Cognitive Behavioral Analysis System of Psychotherapy
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
21 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Integrated Intervention for Substance Abusers With Depressive Disorders

NCT00018655
View directory record Official record
Conditions
Substance-Related Disorders, Depressive Disorder
Interventions
Twelve Step Facilitation, Integrated Cognitive Behavioral Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2019 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Phase 2 Interventional Results available

eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk

NCT04437485
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms, Type 2 Diabetes, PreDiabetes, Insulin Resistance
Interventions
Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications, Active Control
Behavioral · Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Phase 3 Interventional Results available

A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)

NCT03188185
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
ALKS 5461, ALKS 5461 Placebo
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
30
States / cities
Tucson, Arizona • Little Rock, Arkansas • Los Alamitos, California + 27 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Oct 28, 2026, 12:39 AM EDT
Terminated Phase 4 Interventional Results available

Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression

NCT00781326
View directory record Official record
Conditions
Depression
Interventions
Nimodipine, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Gardening on Brain Activity

NCT02225847
View directory record Official record
Conditions
Stress, Depression, Anxiety, Quality of Life
Interventions
Gardening, Functional Magnetic Resonance Imaging (fMRI), psychometric assessments
Other · Procedure · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
26 Years to 49 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MBCT for People With Parkinson's Disease and Caregivers

NCT04469049
View directory record Official record
Conditions
Parkinson Disease, Anxiety, Depression
Interventions
Mindfulness-based cognitive therapy (MBCT)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Compassion Training and Mindfulness Training for Social Well-Being and Mental Health

NCT05227794
View directory record Official record
Conditions
Anxiety, Depression, Stress, Burnout, Emotion Regulation, Social Acceptance, Loneliness, Compassion
Interventions
Compassion Cultivation Training (CCT), Mindfulness-Based Stress Reduction (MBSR)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
290 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Personalized Feedback for Distress Intolerant Smokers

NCT03918031
View directory record Official record
Conditions
Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence, Smoking, Tobacco, Smoking, Cigarette
Interventions
PFI for Smoking & Distress Tolerance, PFI for Smoking Only
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2024 · Synced Oct 28, 2026, 12:39 AM EDT
Completed No phase listed Observational

Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants

NCT00360256
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Oct 28, 2026, 12:39 AM EDT
Completed Not applicable Interventional

Tai Chi Intervention for Chinese Americans With Depression

NCT01619631
View directory record Official record
Conditions
Depression
Interventions
12-week Tai Chi intervention, Education control group
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 1, 2016 · Synced Oct 28, 2026, 12:39 AM EDT