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ClinicalTrials.gov public records Last synced Oct 29, 2026, 2:26 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 937–960 of 5,333 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Recruiting No phase listed Observational

Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

NCT06997549
View directory record Official record
Conditions
Depression, OCD, Anxiety Depression
Interventions
Patients treated with NeuroStar TMS, Patients treated with Esketamine
Device · Drug
Lead sponsor
Neuronetics
Other
Eligibility
5 Years to 100 Years
Enrollment
12,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
1
States / cities
Malvern, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 29, 2026, 2:26 AM EDT
Recruiting Phase 3 Interventional

Creatine for Depressed Male and Female Methamphetamine Users

NCT02568878
View directory record Official record
Conditions
Depression, Anxiety, Methamphetamine Dependence
Interventions
Creatine monohydrate
Drug
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 59 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Dec 11, 2015 · Synced Oct 29, 2026, 2:26 AM EDT
Recruiting Early Phase 1 Interventional

Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression

NCT07560878
View directory record Official record
Conditions
Major Depression
Interventions
D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham, Memantine, Lorazepam (drug), Baclofen, Placebo
Drug · Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Lexapro in the Treatment of Patients With Postpartum Depression

NCT00277108
View directory record Official record
Conditions
Postpartum Depression
Interventions
Escitalopram (Lexapro)
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 6, 2008 · Synced Oct 29, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study

NCT02253225
View directory record Official record
Conditions
Bipolar Disorder, Major Depression, Rumination
Interventions
Functional Magnetic Resonance Imaging (fMRI)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Phase 3 Interventional Results available

Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)

NCT02709655
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Vortioxetine 10 mg/day, Vortioxetine 20 mg/day, Fluoxetine 20mg/day, Placebo
Drug · Other
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
7 Years to 11 Years
Enrollment
683 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
34
States / cities
Little Rock, Arkansas • Imperial, California • Lemon Grove, California + 29 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Oct 29, 2026, 2:26 AM EDT
Not listed Not applicable Interventional

Self-guided Treatment for Depression

NCT06028984
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Intervention app, Control app
Device · Other
Lead sponsor
Big Health Inc.
Industry
Eligibility
13 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2024 · Synced Oct 29, 2026, 2:26 AM EDT
Recruiting No phase listed Observational

Triage Survey for Psychiatry Research Eligibility

NCT05800925
View directory record Official record
Conditions
Major Depressive Disorder, Borderline Personality Disorder, Generalized Anxiety Disorder
Interventions
Survey
Other
Lead sponsor
Adams Clinical
Network
Eligibility
18 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boston, Massachusetts • Watertown, Massachusetts • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 29, 2026, 2:26 AM EDT
Terminated Not applicable Interventional Results available

Comparison of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With Depression

NCT01740726
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Behavioral Activation, Fluoxetine
Behavioral · Drug
Lead sponsor
Emory University
Other
Eligibility
13 Years to 17 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 20, 2017 · Synced Oct 29, 2026, 2:26 AM EDT
Not listed No phase listed Observational

"Assessment of Risk Factors for Depression Treatment at a Safety Net Clinic"

NCT00984685
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Scranton-Temple Residency Program
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Scranton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 25, 2009 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

Adjunctive Treatment of Major Depression Utilizing Auricular Acupuncture

NCT02579343
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Auricular Acupuncture, Sham Auricular Acupuncture + Lexapro
Device · Drug
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
18 Years to 24 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Fort Myers, Florida
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 29, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder

NCT01292889
View directory record Official record
Conditions
Seasonal Affective Disorder
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Oct 29, 2026, 2:26 AM EDT
Not listed Not applicable Interventional

Effects of an Algorithmically Enhanced Personalized Music-based Intervention in Patients With Dementia

NCT06163378
View directory record Official record
Conditions
Music
Interventions
Rubato Life App
Device
Lead sponsor
Rubato Life
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 8, 2023 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Treatment for Teens With Alcohol Abuse and Depression

NCT02227589
View directory record Official record
Conditions
AOD Use, Abuse, and Dependence, Depression
Interventions
MET/CBT-12, CBT-D, D-TAU
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
13 Years to 263 Months
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Farmington, Connecticut • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 29, 2026, 2:26 AM EDT
Active, not recruiting No phase listed Observational

Identifying and Measuring Depression in Older Cancer Patients

NCT02174055
View directory record Official record
Conditions
Older Cancer Patients
Interventions
Patient Interviews, newly developed questionnaire, Pilot Testing the Draft Measure
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
70 Years and older
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence

NCT00149643
View directory record Official record
Conditions
Depressive Disorder, Major, Cannabis Abuse
Interventions
Fluoxetine, Placebo
Drug · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 25 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2013 · Synced Oct 29, 2026, 2:26 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Clinical Validation of a Predictive Test for Postpartum Depression

NCT06831968
View directory record Official record
Conditions
Postpartum Depression (PPD), Pregnancy
Interventions
Enlighten
Diagnostic Test
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Charlottesville, Virginia • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional

A Family Depression Prevention Program

NCT02021578
View directory record Official record
Conditions
Depression
Interventions
Family Cognitive Behavioral Prevention, Written information
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
9 Years to 15 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
2
States / cities
San Diego, California • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Oct 29, 2026, 2:26 AM EDT
Recruiting Phase 2 Interventional

Study of ALTO-300 in MDD

NCT05922878
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
ALTO-300, Placebo
Drug
Lead sponsor
Alto Neuroscience
Industry
Eligibility
18 Years to 70 Years
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
75
States / cities
Phoenix, Arizona • Yuma, Arizona • Rogers, Arkansas + 64 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Journal Program on Wellbeing of NICU Parents

NCT04331925
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Anxiety and depression screening, Journaling
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Oct 29, 2026, 2:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Study of LY2216684 and Theophylline in Healthy Subjects

NCT01263106
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
LY2216684, Theophylline
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 45 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2019 · Synced Oct 29, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Exposure to Stress, Postpartum Mood, Adverse Life Events, and Hormonal Function Among Latinas (SEPAH Latina)

NCT01912833
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Oct 29, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mental Health in Primary Care

NCT05426057
View directory record Official record
Conditions
Depression, Anxiety, Suicide, Drug Use
Interventions
eHealth Familias Unidas Mental Health
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 16 Years
Enrollment
468 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
17
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 29, 2026, 2:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Barefoot Running vs. in Shoes on Physiology and Mood

NCT01733381
View directory record Official record
Conditions
Autonomic Nervous System (ANS) Functioning and Mood State
Interventions
Not listed
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 29, 2026, 2:26 AM EDT