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ClinicalTrials.gov public records Last synced Oct 28, 2026, 9:56 PM EDT

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Showing 1249–1272 of 5,333 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed Phase 2 Interventional Results available

A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

NCT03321526
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
JNJ-42847922, Placebo Matching to JNJ-42847922, Quetiapine XR, Placebo Matching to Quetiapine XR, Selective Serotonin Reuptake Inhibitor (SSRI), Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
50
States / cities
Phoenix, Arizona • Tempe, Arizona • Rogers, Arkansas + 41 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 28, 2026, 9:56 PM EDT
Recruiting Not applicable Interventional

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

NCT07563868
View directory record Official record
Conditions
Treatment Resistant Depression (TRD)
Interventions
Psychedelic Integration Coaching
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 28, 2026, 9:56 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Mood and Behavior Changes Among Overweight Adolescent Females

NCT00127374
View directory record Official record
Conditions
Obesity, Depression
Interventions
Dietary and physical activity modifications
Behavioral
Lead sponsor
University of Kentucky
Other
Eligibility
10 Years to 14 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

The Impact of a School-Based, Trauma-Informed CBT Intervention for Young Women

NCT03376633
View directory record Official record
Conditions
Anxiety, Anxiety Disorders, Behavioral Symptoms, Depression, Mental Disorders, Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Trauma and Stressor Related Disorders, Wounds and Injuries
Interventions
Working on Womanhood (WOW)
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
Female only
Enrollment
5,106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Improving Depression Via E-Health Access (IDEA) Study

NCT04689568
View directory record Official record
Conditions
Depression
Interventions
Moodkit, Moodgym, University of Michigan Depression Center Toolkit
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Pilot Comparison of N-of-1 Trials of Light Therapy

NCT03167372
View directory record Official record
Conditions
Cancer, Health Behavior, Depression
Interventions
Litebook® Advantage, Fitbit Flex2 TM
Other
Lead sponsor
Columbia University
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 28, 2026, 9:56 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Risk Factors for Anxiety and Depression Among Pregnant Women During the COVID-19 Pandemic

NCT04377412
View directory record Official record
Conditions
Anxiety, Depression, Pregnancy Related
Interventions
Pandemic control measures
Other
Lead sponsor
Żelazna Medical Centre, LLC
Other
Eligibility
18 Years and older · Female only
Enrollment
8,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Telephone-Based Counseling for Depression in Parkinson's Disease

NCT02505737
View directory record Official record
Conditions
Depression, Parkinson's Disease
Interventions
TH-CBT, Enhanced Usual Care
Behavioral · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
35 Years to 85 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Thrive Care: Internet CBT for Depression

NCT03079895
View directory record Official record
Conditions
Depression
Interventions
Thrive
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Fontana, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Program for Emotional and Physical Pain - Pilot Randomized Clinical Trial

NCT01769729
View directory record Official record
Conditions
Depression, Chronic Low Back Pain
Interventions
PEPP, Care management
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Pawtucket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 5, 2014 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Transdiagnostic Group Behavioral Activation for Autistic Adults

NCT04788212
View directory record Official record
Conditions
Autism Spectrum Disorder, Depression, Anxiety, Anxiety, Anger
Interventions
Group Behavioral Activation Therapy for Autism Spectrum Disorder
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 40 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

The Momba Mobile Application-based Community

NCT01816945
View directory record Official record
Conditions
Mental Health Wellness 1
Interventions
MOMBA web-based application
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 18, 2021 · Synced Oct 28, 2026, 9:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Curio Digital Therapy for the Treatment of Post-partum Depression

NCT05958095
View directory record Official record
Conditions
PostPartum Depression
Interventions
MamaLift Plus, Digital Sham App
Device
Lead sponsor
Healthcare Innovation Technology Lab
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

Tools for Anxiety and Depression Screening in Epilepsy

NCT05864612
View directory record Official record
Conditions
Epilepsy
Interventions
Screening Questionnaires
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
880 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 28, 2026, 9:56 PM EDT
Not yet recruiting Not applicable Interventional

Feasibility and Acceptability of a Novel Digital Intervention For Perinatal Men Who Have Depression or Anxiety

NCT07742566
View directory record Official record
Conditions
Paternal Postpartum Depression, Postpartum Anxiety
Interventions
Together in Parenting
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 28, 2026, 9:56 PM EDT
Recruiting Phase 2 Interventional

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

NCT07553637
View directory record Official record
Conditions
Treatment-resistant Depression (TRD)
Interventions
ALTO-207, Placebo
Drug
Lead sponsor
Alto Neuroscience
Industry
Eligibility
18 Years to 75 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
53
States / cities
Dothan, Alabama • Phoenix, Arizona • Chino, California + 49 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Oct 28, 2026, 9:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adolescent Mood During Puberty and Testosterone

NCT06072677
View directory record Official record
Conditions
Adolescent Depression
Interventions
Healthy Minds Program
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
11 Years to 14 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mood Lifters: A Self Help Program

NCT02558075
View directory record Official record
Conditions
Depression, Anxiety, Bipolar Disorder
Interventions
MoodLifters Sessions
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

Comprehensive vs. Assisted Management of Mood and Pain Symptoms

NCT01757301
View directory record Official record
Conditions
Pain, Depression, Anxiety, Musculoskeletal, Fibromyalgia
Interventions
Assisted Symptom Management (ASM), Comprehensive Symptom Management (CSM)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Boricua Youth Study COVID-19 Coping Intervention Study

NCT05444881
View directory record Official record
Conditions
Psychological Stress, Depression, Anxiety
Interventions
Mindfulness-based Intervention (Headspace TM)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
Not listed
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 28, 2026, 9:56 PM EDT
Not listed No phase listed Observational

Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome

NCT05419245
View directory record Official record
Conditions
Freeman-Burian Syndrome, Freeman-Sheldon Syndrome, Whistling Face Syndrome, Sheldon-Hall Syndrome, Freeman-Sheldon Syndrome Variant, Arthrogryposis Distal Type 1, Arthrogryposis Distal Type 3, Gordon Syndrome
Interventions
Guided Health History for Freeman-Burian Syndrome Questionnaire, Freeman-Burian syndrome Semi-Structured Quality of Life Interview, Medical Records Review, PTSD Checklist for DSM-5, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale, Review of Systems, FACE-Q | Craniofacial - Appearance of the Face, FACE-Q | Craniofacial - Appearance Distress, FACE-Q | Craniofacial - Facial Function
Other
Lead sponsor
Dufresne, Craig, MD, PC
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Development of a Targeted Patient Portal Intervention to Improve Depression Treatment Adherence and Outcomes

NCT04646681
View directory record Official record
Conditions
Depression
Interventions
ConnectCare
Behavioral
Lead sponsor
Carolyn L Turvey
Other
Eligibility
18 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 10, 2022 · Synced Oct 28, 2026, 9:56 PM EDT
Completed Not applicable Interventional Results available

Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury

NCT00735670
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Venlafaxine HCl, Placebo
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Oct 28, 2026, 9:56 PM EDT
Completed No phase listed Observational

National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database

NCT01591694
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Anxiety, Depression, Conduct Disorder, ADHD
Interventions
Not listed
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
2 Years to 89 Years
Enrollment
4,193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 6, 2018 · Synced Oct 28, 2026, 9:56 PM EDT