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ClinicalTrials.gov public records Last synced Oct 30, 2026, 1:35 PM EDT

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Showing 2137–2160 of 5,335 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder

NCT00071123
View directory record Official record
Conditions
Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional

Storytelling Video Intervention for Depressed Primary Care Patients - Open Trial

NCT02309060
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Storytelling Video Intervention (sTVi)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Pawtucket, Rhode Island • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 30, 2026, 1:35 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention

NCT05700760
View directory record Official record
Conditions
Postpartum Depression
Interventions
ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns), Enhanced Care as Usual (CAU)
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older · Female only
Enrollment
2,320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT)

NCT00279682
View directory record Official record
Conditions
Depression, Suicide, Attempted
Interventions
treatment guidelines and depression care management
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2003
U.S. locations
3
States / cities
White Plains, New York • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 19, 2006 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Phase 1 Interventional Results available

A Study of LY2216684 in Major Depressive Disorder in Patients Taking Selective Serotonin Reuptake Inhibitors

NCT01263223
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
LY2216684, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
St Louis, Missouri • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional

Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment

NCT04667520
View directory record Official record
Conditions
Alcohol Use Disorder, Depression
Interventions
Lifestyle Physical Activity (LPA), Fitbit Only
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Recruiting Not applicable Interventional

Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities

NCT06721559
View directory record Official record
Conditions
Depression
Interventions
Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 30, 2026, 1:35 PM EDT
Terminated Not applicable Interventional Results available

Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms

NCT02422303
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
ketamine
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2018 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Phase 1 Interventional

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

NCT00961454
View directory record Official record
Conditions
Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions
Photobiomodulation with a super-luminous light emitting diode
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Oct 30, 2026, 1:35 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Mental Health Experiences of Sexual and Gender Minorities Living With Cancer and Their Care Partners

NCT05866705
View directory record Official record
Conditions
Depression, Anxiety, Caregiver Burden, Stress, Chronic Illness
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
21 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Oct 30, 2026, 1:35 PM EDT
Withdrawn Phase 4 Interventional

Can Additional Drug Therapy Accelerate Response Time to Antidepressants

NCT00221494
View directory record Official record
Conditions
Depression
Interventions
citalopram + tiodothyronine, or + pindolol, or + placebo
Drug
Lead sponsor
Mark Frye
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Authentic Connections for Nurse Leaders

NCT03616756
View directory record Official record
Conditions
Stress
Interventions
Authentic Connections, Protected time
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 29, 2020 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional

Comparative Effectiveness of Pharmacogenomics for Treatment of Depression

NCT03749629
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
GeneSight Psychotropic test, Canadian Network for Mood and Anxiety Treatment (CANMAT) Best Practice Guidelines
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2022 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effects of Reduced Environmental Stimulation on Anxiety

NCT03051074
View directory record Official record
Conditions
Generalized Anxiety Disorder, Agoraphobia, Panic Disorder, PostTraumatic Stress Disorder, Social Anxiety Disorder, Major Depressive Disorder
Interventions
Floating, Comparison
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Oct 30, 2026, 1:35 PM EDT
Recruiting Not applicable Interventional

Pain and Major Depressive Disorder

NCT04556890
View directory record Official record
Conditions
Major Depressive Disorder, Chronic Pain
Interventions
Active rTMS/Active iTBS DFPLC/Sham Pain M1, Active rTMS/Active iTBS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Active, not recruiting Not applicable Interventional

AYA-PeerConnect: A Communication Coaching Intervention for Adolescent/Young Adult Cancer Survivors (AYACS)

NCT07454460
View directory record Official record
Conditions
Communication, Anxiety, Depression, Social Isolation
Interventions
Asynchronous coaching and artificial intelligence (AI) Yoodli coach sessions
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Completed No phase listed Observational

Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms

NCT04611620
View directory record Official record
Conditions
Survivorship, Cognitive Dysfunction, Pain, Depression, Anxiety, Fatigue, Sleep Disturbance
Interventions
Cognitive Dysfunction
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
682 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional

taVNS on the Inpatient Psychiatric Unit

NCT05791383
View directory record Official record
Conditions
Depression, Anxiety
Interventions
transcutaneous auricular neurostimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Not applicable Interventional Results available

Depression Outpatient Cardiology Screening Study

NCT01552889
View directory record Official record
Conditions
Depression, Coronary Heart Disease
Interventions
Collaborative Care
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Oct 30, 2026, 1:35 PM EDT
Recruiting Phase 3 Interventional

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

NCT07592689
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Placebo, DT120
Other · Drug
Lead sponsor
Definium Therapeutics US, Inc.
Industry
Eligibility
18 Years to 74 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
30
States / cities
Little Rock, Arkansas • Orange, California • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Recruiting Not applicable Interventional

Home-Based tDCS Treatment Of Major Depressive Disorder

NCT06976697
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
Transcranial direct current stimulation, Sham transcranial direct current stimulation
Device
Lead sponsor
Sooma Medical Inc
Industry
Eligibility
22 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Phase 4 Interventional

Adjunctive Transcranial Direct Current Stimulation for Cognition in Major Depression

NCT00760097
View directory record Official record
Conditions
Depression
Interventions
Transcranial direct stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2013 · Synced Oct 30, 2026, 1:35 PM EDT
Recruiting Phase 2 Interventional

JAK Signaling in Depression

NCT07003997
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Baricitinib, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
25 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 30, 2026, 1:35 PM EDT
Completed Phase 2 Interventional Results available

A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disorder

NCT00555997
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ziprasidone, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
7
States / cities
Los Angeles, California • Farmington, Connecticut • Norwich, Connecticut + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2014 · Synced Oct 30, 2026, 1:35 PM EDT