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ClinicalTrials.gov public records Last synced Oct 30, 2026, 10:29 AM EDT

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Showing 2161–2184 of 5,335 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Improving Preterm Outcomes by Safeguarding Maternal Mental Health

NCT01892982
View directory record Official record
Conditions
Depression, Child Development
Interventions
Problem Solving Education tailored to NICU
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
Up to 64 Years
Enrollment
325 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
4
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Inner Engineering Yoga Program on Short and Long Term Health Effects (ISHA-Impact): A Longitudinal Study

NCT04189146
View directory record Official record
Conditions
Mediation, Mood, Stress, Habits, Nicotine, Alcohol Consumption, Pain Intensity, Sleep, Mindfulness, Emotions, Anxiety, Depression
Interventions
Inner Engineering Intervention
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
618 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Oct 30, 2026, 10:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Internet Based Psychological Support

NCT02726061
View directory record Official record
Conditions
Depression, Stress, Conflict Resolution
Interventions
Internet-based psychological support
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2031
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Phase 3 Interventional

A 24-52-week Study to Evaluate the Long-term Efficacy and Safety of Saredutant in Patients With Depression (MAGENTA)

NCT00336713
View directory record Official record
Conditions
Depressive Disorder
Interventions
Saredutant (SR48968C), Placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 30, 2026, 10:29 AM EDT
Completed No phase listed Observational

Antidepressant Safety in Kids Study

NCT00395213
View directory record Official record
Conditions
Anxiety Disorders, Depressive Disorders, Eating Disorders, Obsessive Compulsive Disorder
Interventions
Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) medications
Drug
Lead sponsor
Duke University
Other
Eligibility
7 Years to 17 Years
Enrollment
569 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2015 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg

NCT06719986
View directory record Official record
Conditions
Opioid Overdose
Interventions
Nalmefene HCl injection, Naloxone HCl intranasal
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Digital Cognitive Behavior Therapy Program for Suicide Prevention

NCT03595254
View directory record Official record
Conditions
Suicidal Ideation, Depression, Anxiety
Interventions
Thrive
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
18 Years and older
Enrollment
725 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 30, 2026, 10:29 AM EDT
Recruiting Not applicable Interventional

Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments

NCT06976840
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
Intermittent theta burst stimulation, Sham theta burst stimulation, Continuous theta burst stimulation
Device
Lead sponsor
Marta Peciña, MD PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adolescent Attention to Emotion Study

NCT04105868
View directory record Official record
Conditions
Depression
Interventions
Neurofeedback
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 15 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Oct 30, 2026, 10:29 AM EDT
Recruiting Not applicable Interventional

Mechanisms of Rumination Change in Adolescent Depression

NCT03859297
View directory record Official record
Conditions
Major Depressive Disorder, Mood Disorders
Interventions
Rumination-Focused CBT, Relaxation-based Therapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
14 Years to 17 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
3
States / cities
Columbus, Ohio • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 30, 2026, 10:29 AM EDT
Terminated Phase 4 Interventional Results available

Lexapro for Major Depression in Patients With Epilepsy

NCT01244724
View directory record Official record
Conditions
Major Depression, Epilepsy
Interventions
Lexapro
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Results available

Project Bridge: Peer Health Navigator Intervention

NCT02022462
View directory record Official record
Conditions
Schizophrenia, Depression, Medical Disorders, Serious Mental Illness
Interventions
Health Navigation
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Santa Fe Springs, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2024 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Body Hyperthermia and Major Depression (MDD)

NCT01625546
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Whole Body Hyperthermia system
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Oct 30, 2026, 10:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Depression and Cesarean Section

NCT00370903
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
15 Years to 43 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 4, 2008 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Results available

A Systems-Level Intervention for Rural Adults With Depression

NCT04502186
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Raising Our Spirits Together, Enhanced Control Condition
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Hillsdale, Michigan • Jonesville, Michigan
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Results available

Imaging Predictors of Treatment Response in Depression

NCT00367341
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
escitalopram, Cognitive Behavioral Therapy (CBT)
Drug · Behavioral
Lead sponsor
Emory University
Other
Eligibility
21 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 9, 2014 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Effect of EFT on Psychological States in a Veterans Population

NCT00743041
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Emotional Freedom Techniques (EFT)
Behavioral
Lead sponsor
Soul Medicine Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 30, 2026, 10:29 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Whole-Body Hyperthermia for Mood and Anxiety Disorders

NCT06144294
View directory record Official record
Conditions
Postpartum Depression, Mood Disorders, Anxiety Disorders, Postpartum Anxiety
Interventions
Whole-Body Hyperthermia, fMRI
Other · Diagnostic Test
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 50 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2028 – 2032
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Results available

The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)

NCT04279522
View directory record Official record
Conditions
MDD
Interventions
Relivion®DP- Active, Relivion®DP- Sham
Device
Lead sponsor
Neurolief Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
12
States / cities
La Jolla, California • Los Angeles, California • Miami Lakes, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 30, 2026, 10:29 AM EDT
Recruiting Not applicable Interventional

Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study

NCT07577947
View directory record Official record
Conditions
Depression, Perinatal Depression
Interventions
Perinatal depression online cognitive-behavioral therapy course, Clinical care (psychotherapy sessions)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 30, 2026, 10:29 AM EDT
Completed No phase listed Observational

The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors

NCT01317147
View directory record Official record
Conditions
Gastric Bypass, Depression, Anxiety Disorder
Interventions
Roux-en-Y gastric bypass (RYGBP)
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2011 · Synced Oct 30, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Positive Feedback vs. No-Feedback Games for Behavioral Change

NCT06025838
View directory record Official record
Conditions
Major Depressive Disorder, Low Mood
Interventions
positive feedback
Behavioral
Lead sponsor
Bard College
Other
Eligibility
18 Years to 34 Years
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Annandale-on-Hudson, New York
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Oct 30, 2026, 10:29 AM EDT
Completed No phase listed Observational Results available

Genetic and Biochemical Markers of Interferon-Induced Depression.

NCT00252538
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Long Beach, California • Minneapolis, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 11, 2014 · Synced Oct 30, 2026, 10:29 AM EDT
Recruiting Phase 2 Interventional

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

NCT06559826
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ketamine, Psychotherapy
Drug · Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 90 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 30, 2026, 10:29 AM EDT