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ClinicalTrials.gov public records Last synced Oct 30, 2026, 3:48 PM EDT

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Showing 2209–2232 of 5,335 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed Phase 2 Interventional Results available

Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)

NCT00731653
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Combination Product: BCI-024 + BCI-049
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
9
States / cities
Garden Grove, California • San Diego, California • Altanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2013 · Synced Oct 30, 2026, 3:48 PM EDT
Recruiting Not applicable Interventional

Heat and Mental Health - PART 2

NCT07903896
View directory record Official record
Conditions
Depressed Mood, Young Adults, Heat Stress, Sleep
Interventions
Heat/Humidity Exposure Condition, Thermoneutral Condition
Other
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 25 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Orange, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 29, 2026 · Synced Oct 30, 2026, 3:48 PM EDT
Completed No phase listed Observational

Functional and Neurochemical Brain Changes Bipolar Depression

NCT00608296
View directory record Official record
Conditions
Depression, Bipolar
Interventions
Not listed
Lead sponsor
University of Cincinnati
Other
Eligibility
12 Years to 35 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional

MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home

NCT02972203
View directory record Official record
Conditions
Depression, Anxiety, Stress Related Disorder, Adjustment Disorder
Interventions
Mindfulness Training for Primary Care, Mindfulness Intro. +resources +waitlist
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Phase 3 Interventional Results available

Lamotrigine for Symptoms of Geriatric Bipolar Depression

NCT00621842
View directory record Official record
Conditions
Bipolar Disorder, Depression, Bipolar
Interventions
Lamotrigine regular tablet formulation, Lamotrigine novel formulation
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
60 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
5
States / cities
White Plains, New York • Cleveland, Ohio • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2014 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional

Gratitude Intervention for Cardiac Rehabilitation Patients

NCT04314583
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
Attention Control, Gratitude Journaling
Behavioral
Lead sponsor
Martha Biddle
Other
Eligibility
18 Years to 100 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 30, 2026, 3:48 PM EDT
Completed No phase listed Observational

Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants

NCT00360256
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Results available

Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits

NCT01466751
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Computerized Neurobehavioral Intervention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional

The Reducing Risk Study

NCT03665337
View directory record Official record
Conditions
Insomnia, Delayed Sleep Phase
Interventions
mTranS-C, Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 18 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 30, 2026, 3:48 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)

NCT05942469
View directory record Official record
Conditions
Burnout, Burnout, Professional, Positive Affect, Depression, Anxiety, Compassion Fatigue, Job Stress
Interventions
FOREST
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PERsonalized Mood Augmentation Trial for Depressed Mood

NCT05662254
View directory record Official record
Conditions
Depression
Interventions
Personalized Behavioral Intervention
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
15 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Phase 4 Interventional Results available

A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health

NCT05604794
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder
Interventions
Ketamine-Assisted Psychotherapy (KAP)
Combination Product
Lead sponsor
Field Trip Health
Industry
Eligibility
19 Years and older
Enrollment
1,806 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
8
States / cities
Los Angeles, California • San Diego, California • Washington D.C., District of Columbia + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 30, 2026, 3:48 PM EDT
Not listed Phase 1 Interventional

Motivational and Cognitive Intervention for College Drinkers

NCT01204229
View directory record Official record
Conditions
Alcohol Consumption, Anxiety, Depression
Interventions
Motivational and Cognitive Intervention for Drinkers (MCID), Brief Motivational Intervention (BMI)
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 22, 2011 · Synced Oct 30, 2026, 3:48 PM EDT
Terminated Not applicable Interventional Results available

[Study Evaluating the Efficacy and Safety of a Digital Therapeutic as an Adjunct to TAU in Postpartum Depression]

NCT05551195
View directory record Official record
Conditions
Postpartum Depression
Interventions
WB001, ED001
Device
Lead sponsor
Woebot Health
Industry
Eligibility
22 Years to 45 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
8
States / cities
Lafayette, California • Santa Ana, California • DeLand, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Results available

IntelliCare Study: Artificial Intelligence in a Mobile (AIM) Intervention for Depression

NCT02801877
View directory record Official record
Conditions
Depression, Anxiety
Interventions
IntelliCare, Hub App with the Recommender System, Coaching
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Phase 3 Interventional Results available

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)

NCT02943577
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Rapastinel, Placebo
Drug
Lead sponsor
Naurex, Inc, an affiliate of Allergan plc
Industry
Eligibility
18 Years to 65 Years
Enrollment
429 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
40
States / cities
Dothan, Alabama • Phoenix, Arizona • Imperial, California + 34 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2019 · Synced Oct 30, 2026, 3:48 PM EDT
Recruiting No phase listed Observational

The OBSERVE Protocol

NCT06725277
View directory record Official record
Conditions
Major Depression Disorder
Interventions
Spravato, IV Ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
8
States / cities
Milford, Connecticut • New Haven, Connecticut • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence

NCT00377299
View directory record Official record
Conditions
Amphetamine Abuse, Amphetamine Dependence, Bipolar Disorder, Major Depressive Disorder
Interventions
Citicoline, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Oct 30, 2026, 3:48 PM EDT
Not listed Not applicable Interventional

Treatment of Insomnia and Depression in Elders (TIDE)

NCT01648049
View directory record Official record
Conditions
Depression, Insomnia
Interventions
Integrated Cognitive Behavioral Therapy (CBT), Treatment as usual
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
50 Years to 100 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Results available

Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression

NCT03191058
View directory record Official record
Conditions
Depression, Unipolar Depression, Treatment Resistant Depression
Interventions
Magnetic Seizure Therapy, Electroconvulsive Therapy
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
239 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
San Diego, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 30, 2026, 3:48 PM EDT
Recruiting Not applicable Interventional

Deconstructing Maternal Burdens: Doulas and the Community Unite for Health

NCT07799805
View directory record Official record
Conditions
Pregnancy, Post Partum, Doula Care, Postpartum Depression (PPD), Perinatal Depression, Perinatal Anxiety, Health Disparities, Pregnancy Complications, Maternal Adverse Outcomes
Interventions
Doula, Standard (non-enhanced) Medicaid doula support
Other
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 49 Years · Female only
Enrollment
516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Activating and Connecting Teens (ACT) Study

NCT03438656
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 18 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Oct 30, 2026, 3:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Trial of Online LGBTQ-affirmative Cognitive Behavioral Therapy to Reduce Depression and Associated Health Risks Among Young Adults

NCT04408469
View directory record Official record
Conditions
LGBTQ, Sexual Behavior
Interventions
Online EQuIP, Self-monitoring control
Behavioral
Lead sponsor
Yale University
Other
Eligibility
16 Years to 25 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Oct 30, 2026, 3:48 PM EDT
Completed No phase listed Observational Results available

Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant

NCT01084694
View directory record Official record
Conditions
Depression, Anxiety, Fatigue, Distress
Interventions
Not listed
Lead sponsor
Northside Hospital, Inc.
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2020 · Synced Oct 30, 2026, 3:48 PM EDT