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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:28 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 98 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depression in Old Age Clear all

Conditions: Depression
Interventions: Depression CAREPATH, Usual Care; Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 65 Years and older
Enrollment: 310 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2009
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Major Depression, Dementia
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 60 Years and older
Enrollment: 795 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1995 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Depression, Cognition Disorders
Interventions: Problem Solving Therapy, Brief Supportive Therapy; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 60 Years and older
Enrollment: 221 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2008
U.S. locations: 2
States / cities: San Francisco, California • White Plains, New York

Conditions: Major Depressive Disorder
Interventions: Memantine; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 55 Years to 89 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Bipolar Depression Depressed Phase
Interventions: Active Low Field Magnetic Stimulation, Sham Low Field Magnetic Stimulation; Device
Lead sponsor: Mclean Hospital; Other
Eligibility: 55 Years to 85 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Subjective Cognitive Decline, Depression in Old Age
Interventions: PeersCOG; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 60 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression, Depression in Old Age, Elder Abuse, Anxiety
Interventions: PROTECT with Technology Augmentation; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 55 Years to 100 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression, Major Depressive Disorder, Treatment-Refractory Depression, Late Life Depression, Geriatric Depression
Interventions: Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion, Lithium Augmentation, Switch to nortriptyline; Drug
Lead sponsor: Centre for Addiction and Mental Health; Other
Eligibility: 60 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 3
States / cities: Los Angeles, California • St Louis, Missouri • New York, New York

Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
Interventions: L-Dopa, Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 79 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Nashville, Tennessee

Conditions: Major Depressive Disorder
Interventions: Quetiapine; Drug
Lead sponsor: AstraZeneca; Industry
Eligibility: 66 Years and older
Enrollment: 338 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 13
States / cities: Birmingham, Alabama • San Diego, California • Fort Myers, Florida + 10 more

Conditions: Depressive Disorder, Major
Interventions: Seltorexant, Placebo; Drug
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years to 74 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 39
States / cities: Bryant, Arkansas • Bellflower, California • Glendale, California + 31 more

Conditions: Breast Cancer, Prostate Cancer, Lung Cancer, Lymphoma Cancer, Gynecological Cancers
Interventions: group intervention and questionnaires, individual phone intervention and questionnaires, expressive writing (arm will not be include in the randomization); Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 70 Years and older
Enrollment: 107 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2025
U.S. locations: 2
States / cities: New York, New York • Philadelphia, Pennsylvania

Conditions: Exercise, Gait, Cognitive Decline, Caregiver Burden, Cognitive Impairment, Dementia, Alzheimer Disease, Mild Cognitive Impairment, Respite Care, Mental Health, Depression, Music Therapy, Psychosocial Intervention, Cognition, Geriatric Assessment, Cognitive Dysfunction, Cognitive Aging, Outcome Assessment, Health Care, Balance, Fall, Walking, Affect, Physical Exertion, Memory Deficit, Memory Disorders, Memory Impairment, Neuropsychological Tests, Executive Function, Middle Aged, Healthy Aging, Elderly
Interventions: Group exercise program; Behavioral
Lead sponsor: University of North Carolina, Greensboro; Other
Eligibility: 55 Years to 99 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Greensboro, North Carolina

Conditions: Major Depression Disorder
Interventions: Adjunct brexpiprazole, ADT; Drug
Lead sponsor: H. Lundbeck A/S; Industry
Eligibility: 65 Years and older
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 13
States / cities: Arcadia, California • Miami, Florida • Orlando, Florida + 9 more

Conditions: Depression, Dysthymic Disorder
Interventions: Duloxetine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 60 Years to 95 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression
Interventions: Escitalopram; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 60 Years to 85 Years
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Depression
Interventions: ABP688; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 55 Years to 80 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: New York, New York • Pittsburgh, Pennsylvania

Conditions: Depression, Major Depressive Episode, Bipolar Disorder
Interventions: MagVenture MagPro MST, RUL ECT; Device · Biological
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 55 Years to 90 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
Interventions: Engage; Behavioral
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 60 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Depressive Disorder, Major, Major Depressive Disorder (MDD)
Interventions: Paroxetine CR; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 60 Years and older
Enrollment: 560 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 46
States / cities: Little Rock, Arkansas • Anaheim, California • Beverly Hills, California + 40 more

Conditions: Cognitive Function, Depression in Old Age
Interventions: Physical exercise (PE) training and computer-based brain (CBB); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 65 Years and older
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Depression
Interventions: venlafaxine-XR; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 60 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2000
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: Treatment of depression, Suicide prevention intervention, Suicide prevention treatment; Drug · Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 60 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2003
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Depression
Interventions: Problem Solving Therapy, Dietary Education; Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 50 Years and older
Enrollment: 306 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Effectiveness of a Depression Care Management Initiative in Home Healthcare

Neurocognitive Outcomes of Depression in the Elderly

Therapy for Depressed Elders With Thought Problems

Treatment Resistant Geriatric Depression in Primary Care

LFMS: Initial Trial in Geriatric Bipolar Depression

Developing a Peer Support Intervention for Depression in SCD

Trial to Test Effectiveness of Depression Intervention for Mistreated Older Adults

RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)

Dopaminergic Dysfunction in Late-Life Depression

Efficacy and Safety Study of Seroquel SR in the Treatment of Major Depressive Disorder

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

A Pilot Study of Geriatric Specific Interventions for Quality of Life in Elderly Patients With Cancer

Rhythmically Entrained Exercise in Community-Dwelling Older Adults

Evaluation of the Safety of Adjunct Brexpiprazole in Elderly Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Treatment

Duloxetine Treatment in Elderly With Dysthymia

Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression

Characterize the Regional Distribution of [11C] ABP688 in Brain by Positron Emission Tomography (PET)

Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults

Engage for Late-Life Depression and Comorbid Executive Dysfunction

Depression Study In Elderly Patients

Computer Presented and Physical Exercises to Maintain Cognitive Function and Emotional Health in Older Adults

Safety and Efficacy of Venlafaxine XR in Elderly Patients With Major Depression

Prevention of Suicide in the Elderly

Primary Prevention of Major Depression in Later Life