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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Disc Degeneration;Cervical Clear all
Enrolling by invitation No phase listed Observational

Long-Term Assessment of the Safety and Performance of the NuVasive Simplify Disc at Two Levels

NCT05691231
View directory record Official record
Conditions
Cervical Disc Disease, Degenerative Disc Disease
Interventions
NuVasive Simplify Cervical Artificial Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
2
States / cities
Charlotte, North Carolina • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Active, not recruiting Not applicable Interventional

Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels

NCT04214535
View directory record Official record
Conditions
Cervical Disc Herniation, Cervical Disc Degeneration, Degenerative Disc Disease
Interventions
Tritanium C Anterior Cervical Cage
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 10:51 PM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery

NCT05740176
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
23
States / cities
Scottsdale, Arizona • Beverly Hills, California • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Not applicable Interventional

PRESTIGE® Cervical Disc Study

NCT00642876
View directory record Official record
Conditions
Degenerative Cervical Disc Disease
Interventions
Allograft Fusion and ATLANTIS™ Cervical Plate System, PRESTIGE® Cervical Disc
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
541 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2013
U.S. locations
31
States / cities
Huntsville, Alabama • Montgomery, Alabama • Sacramento, California + 26 more
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jul 22, 2026, 10:51 PM EDT
Terminated No phase listed Observational

PureGen: Radiographic Analysis of Fusion for ACDF

NCT01291134
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
PureGen Osteoprogenitor Cell Allograft
Biological
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Carlsbad, California • Middletown, Connecticut • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Jul 22, 2026, 10:51 PM EDT
Active, not recruiting No phase listed Observational

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

NCT05258435
View directory record Official record
Conditions
Cervical Disc Disease, Degenerative Disc Disease
Interventions
NuVasive Simplify Cervical Artificial Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
10
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Active, not recruiting No phase listed Observational

M6-C Post Approval Study (PAS)

NCT04122248
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Interventions
standard radiographic imaging, cervical total disc replacement
Other · Device
Lead sponsor
Spinal Kinetics
Industry
Eligibility
21 Years to 68 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
21
States / cities
Phoenix, Arizona • Sun City West, Arizona • Beverly Hills, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Terminated No phase listed Observational

Bone Graft Materials Observational Registry

NCT00974623
View directory record Official record
Conditions
Degenerative Disc Disease, Herniated Disc, Spinal Stenosis, Spondylolithesis, Spinal Deformity, Cervical Myelopathy, Failed Back Surgery Syndrome, Spinal Cord Neoplasms
Interventions
Bone graft substitute, autograft or allograft
Device
Lead sponsor
Baxter Healthcare Corporation
Industry
Eligibility
18 Years and older
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
12
States / cities
San Francisco, California • Atlanta, Georgia • Carrollton, Georgia + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE

NCT00389597
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical Artificial Disc
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
18 Years to 69 Years
Enrollment
599 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
24
States / cities
Phoenix, Arizona • Escondido, California • Laguna Hills, California + 21 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2017 · Synced Jul 22, 2026, 10:51 PM EDT
Recruiting No phase listed Observational

Conduit Cages and Fibergraft BG Putty

NCT06704919
View directory record Official record
Conditions
Degenerative Disc Disease, Herniated Disc
Interventions
Use of conduit cages and fibergraft BG Putty
Device
Lead sponsor
Nitin Agarwal
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Phase 3 Interventional Results available

Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD

NCT00667459
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
PRESTIGE® LP Cervical Disc, ATLANTIS Anterior Cervical Plate
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
16
States / cities
Atlanta, Georgia • Columbus, Georgia • Coeur d'Alene, Idaho + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Jul 22, 2026, 10:51 PM EDT
Not yet recruiting No phase listed Observational

Assessing Safety of Cervical Spine Fusion With NMP®

NCT07245940
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis Cervical
Interventions
Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Red Rock Regeneration Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

ACDF Using Structural Allograft vs. Tritanium C

NCT04388332
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Structural allograft, Tritanium C
Procedure · Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating The Safety and Effectiveness of The NeoDisc™ Versus ACDF in Subjects With Single-Level Cervical Disc Disease

NCT00478088
View directory record Official record
Conditions
Cervical Disc Degenerative Disorder
Interventions
NeoDisc, Instrumented Anterior Cervical Discectomy and Fusion (ACDF)
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 60 Years
Enrollment
488 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
22
States / cities
La Jolla, California • Marina del Rey, California • Santa Monica, California + 19 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Completed No phase listed Observational

Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF)

NCT00951938
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
13
States / cities
Encinitas, California • Redding, California • Parker, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Jul 22, 2026, 10:51 PM EDT
Enrolling by invitation No phase listed Observational

Cervical Interbody Implant Study

NCT04689854
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spinal Instability
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Somerville, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Enrolling by invitation No phase listed Observational

Posterior Cervical Fixation Study

NCT04770571
View directory record Official record
Conditions
Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease, Cervical Fusion, Cervical Spine Disease, Cervical Myelopathy, Cervical Instabilities Spine, Thoracic Injury
Interventions
observational study
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Hyattsville, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Not listed No phase listed Observational

A Retrospective Study to Examine the Effect of CMF Stimulation on Primary ACDF Patients

NCT05101057
View directory record Official record
Conditions
Degeneration of Cervical Intervertebral Disc
Interventions
SpinalogicTM Bone Graft Stimulator
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
San Diego, California • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Dec 6, 2021 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Investigation of the Simplify® Cervical Artificial Disc

NCT02667067
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Simplify Disc, Anterior Cervical Discectomy & Fusion
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
16
States / cities
La Jolla, California • Orange, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 10:51 PM EDT
Active, not recruiting Not applicable Interventional

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
Procedure · Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
17
States / cities
Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 22, 2026, 10:51 PM EDT
Terminated Not applicable Interventional

Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)

NCT00374413
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
Artificial disk, Artificial disc
Device
Lead sponsor
SpinalMotion
Industry
Eligibility
18 Years to 60 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
21
States / cities
Beverly Hills, California • Oakland, California • San Diego, California + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2013 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Not applicable Interventional

Comparison of Outcomes Between Early Physical Therapy Intervention and Usual Care Following Anterior Cervical Fusion Surgery

NCT01519115
View directory record Official record
Conditions
Cervical Spine Degenerative Disc Disease, Fusion of Spine, Cervical Region
Interventions
early physical therapy intervention, usual care
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
30 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2015 · Synced Jul 22, 2026, 10:51 PM EDT
Withdrawn Not applicable Interventional

Stand-Alone Cage Verus Anterior Plating for Anterior Cervical Discectomy and Fusion.

NCT03312192
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spine Degeneration
Interventions
Interbody Cage, Interbody Cage and Anterior Plating
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Jul 22, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Investigation of the Two Level Simplify® Cervical Artificial Disc

NCT03123549
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
18
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 10:51 PM EDT