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ClinicalTrials.gov public records Last synced Oct 11, 2026, 5:22 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 27,462 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Diseases of the Nervous System Clear all
Completed No phase listed Observational

A Health & Wellness Intervention for Individuals With Traumatic Brain Injury (TBI)

NCT01334398
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Health & Wellness
Behavioral
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 25, 2014 · Synced Oct 11, 2026, 5:22 AM EDT
Terminated Phase 2 Interventional Results available

A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease

NCT01255163
View directory record Official record
Conditions
Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Exendin-4 SC, Placebo SC
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
60 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 11, 2026, 5:22 AM EDT
Terminated Phase 2 Interventional Results available

Open-Label Extension of the PTI-125-04 Study in Mild-to-Moderate Alzheimer's Disease

NCT05352763
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
simufilam
Drug
Lead sponsor
Cassava Sciences, Inc.
Industry
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
9
States / cities
Gilbert, Arizona • Imperial, California • Delray Beach, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D2, Muscle Damage, NASCAR Pitcrew

NCT01825616
View directory record Official record
Conditions
Muscle Function, Muscle Soreness, Vitamin D Status
Interventions
Vitamin D2 mushroom powder, Placebo
Dietary Supplement · Other
Lead sponsor
Appalachian State University
Other
Eligibility
20 Years to 40 Years · Male only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
3
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2013 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study of Laser Analgesia in Cavity Preparations Using the Er,Cr:YSGG Laser

NCT03946904
View directory record Official record
Conditions
Tooth Pain
Interventions
Er,Cr:YSGG Laser
Device
Lead sponsor
Chen Laser Institute
Other
Eligibility
19 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Granite City, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Oct 11, 2026, 5:22 AM EDT
Active, not recruiting Not applicable Interventional

Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)

NCT05649384
View directory record Official record
Conditions
Acute Chest Pain, NSTEMI - Non-ST Segment Elevation MI
Interventions
European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm, European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm
Diagnostic Test
Lead sponsor
University Hospital, Basel, Switzerland
Other
Eligibility
18 Years and older
Enrollment
64,374 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Not applicable Interventional Results available

Precision Diagnosis of Acute Infectious Diseases; Neuroinflammatory Cohort

NCT02910037
View directory record Official record
Conditions
Encephalitis, Meningitis
Interventions
mNGS for pathogen detection
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
1 Minute to 110 Years
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
7
States / cities
Davis, California • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Oct 11, 2026, 5:22 AM EDT
Completed No phase listed Observational

Study of Eye Pressure as a Predictor of Intracranial Pressure in the Acutely Head-Injured Population

NCT00534157
View directory record Official record
Conditions
Craniocerebral Trauma
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2007 · Synced Oct 11, 2026, 5:22 AM EDT
Recruiting Phase 2 Interventional

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions

NCT04343157
View directory record Official record
Conditions
Brain Metastases, Adult, Neurocognitive Function, Cancer, Meningioma of Brain, Arteriovenous Malformations, Cerebral
Interventions
Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
Radiation
Lead sponsor
Jona Hattangadi-Gluth
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 11, 2026, 5:22 AM EDT
Recruiting Not applicable Interventional

Autologous Mitochondrial Transplant for Cerebral Ischemia

NCT04998357
View directory record Official record
Conditions
Cerebral Ischemia
Interventions
Endovascular autologous mitochondrial transplantation
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Oct 11, 2026, 5:22 AM EDT
Recruiting No phase listed Observational

Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi

NCT06599619
View directory record Official record
Conditions
Melanoma
Interventions
Single agent, adjuvant anti-PD1 therapy
Drug
Lead sponsor
John Kirkwood
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Musical Therapeutic Intervention on Depression in Dementia Patients and Caregiver Burden

NCT07069530
View directory record Official record
Conditions
Dementia, Alzheimer Disease (AD), Depression Chronic, Caregiver Burden of People With Dementia, Cognitive Impairments
Interventions
Receptive Music Therapy
Behavioral
Lead sponsor
Florida SouthWestern State College
Other
Eligibility
25 Years to 90 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Myers, Florida
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Not applicable Interventional

Evaluation of Memory Skills in Patients Receiving Radiation Therapy for Brain Metastases

NCT00007007
View directory record Official record
Conditions
Cognitive/Functional Effects, Metastatic Cancer, Radiation Toxicity
Interventions
management of therapy complications, quality-of-life assessment
Procedure
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
0 Years to 120 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
223
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 174 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 11, 2026, 5:22 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Intervention for Hearing Health Among Native Americans

NCT07534098
View directory record Official record
Conditions
Noise-Induced Hearing Loss
Interventions
Talking Circle, Diabetes prevention program & delayed TC
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2030
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 11, 2026, 5:22 AM EDT
Recruiting Not applicable Interventional

GyroStim for Post Concussion Syndrome

NCT07527663
View directory record Official record
Conditions
Post Concussion Syndrome
Interventions
Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
Device · Other
Lead sponsor
Neuroscience Group
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Appleton, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 11, 2026, 5:22 AM EDT
Terminated Not applicable Interventional

Measuring Evoked Potentials From the Spinal Cord and Dorsal Root Ganglion

NCT03976219
View directory record Official record
Conditions
Neuropathic Pain
Interventions
ECAPS Closed Loop SCS
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Oct 11, 2026, 5:22 AM EDT
Terminated Not applicable Interventional

Impedance Threshold Device Tilt Study

NCT00137319
View directory record Official record
Conditions
Orthostatic Hypotension
Interventions
Impedance threshold device
Device
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2015 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain

NCT03058965
View directory record Official record
Conditions
Alzheimer Disease, Healthy Volunteers, Progressive Supranuclear Palsy
Interventions
[18F]MNI-958, [18F]Florbetapir, DaTscan
Drug
Lead sponsor
Molecular NeuroImaging
Other
Eligibility
50 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Oct 11, 2026, 5:22 AM EDT
Terminated Not applicable Interventional

Temporally Optimized Patterned Stimulation (TOPS®) Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease

NCT04390867
View directory record Official record
Conditions
Parkinson Disease
Interventions
TOPS1 DBS, TOPS2 DBS, TOPS3 DBS, Standard DBS
Device
Lead sponsor
Deep Brain Innovations LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Gainesville, Florida • Chicago, Illinois • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 11, 2026, 5:22 AM EDT
Completed Not applicable Interventional

Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs

NCT00797407
View directory record Official record
Conditions
Hypercholesterolemia, Aches, Cramps, Weakness
Interventions
Creatine
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Wooster, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 25, 2008 · Synced Oct 11, 2026, 5:22 AM EDT
Active, not recruiting Not applicable Interventional

Occupational Therapy Led Social Prescription for People With Parkinson Disease

NCT06447207
View directory record Official record
Conditions
Parkinson Disease
Interventions
Occupational Therapy Led Social Prescription
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 11, 2026, 5:22 AM EDT
Terminated Phase 1 Interventional Results available

A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild to Moderate Alzheimer's Disease

NCT01028911
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
PF-03654746, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
55 Years to 85 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2014 · Synced Oct 11, 2026, 5:22 AM EDT
Completed No phase listed Observational

Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases

NCT00076271
View directory record Official record
Conditions
Eye Diseases
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
Not listed
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
2
States / cities
Denver, Colorado • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 11, 2026, 5:22 AM EDT
Active, not recruiting Phase 2 Interventional

AMX0035 in Adult Patients With Wolfram Syndrome

NCT05676034
View directory record Official record
Conditions
Wolfram Syndrome
Interventions
AMX0035
Drug
Lead sponsor
Amylyx Pharmaceuticals Inc.
Industry
Eligibility
17 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 11, 2026, 5:22 AM EDT