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ClinicalTrials.gov public records Last synced Sep 18, 2026, 6:53 PM EDT

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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Disinfection Clear all
Not yet recruiting Not applicable Interventional

Histological Evaluation in the Efficacy of GentleWave in Root Canal Pulp Tissue Debridement and Disinfection of Difficult to Reach Areas in Mandibular Human Molars II. An In-vivo Study.

NCT04105907
View directory record Official record
Conditions
Root Canal Treatment
Interventions
GentleWave
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional

Effectiveness of Enhanced Terminal Room Disinfection to Prevent Healthcare-associated Infections (HAIs)

NCT01579370
View directory record Official record
Conditions
Multidrug Resistant Organisms, Healthcare Associated Infections
Interventions
Quaternary ammonium, Bleach, Quaternary ammonium and UV-C light, Bleach and UV-C light
Other
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
21,395 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
9
States / cities
Burlington, North Carolina • Chapel Hill, North Carolina • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Sep 18, 2026, 6:53 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

NCT05959629
View directory record Official record
Conditions
Endodontic Disease, Root Canal Infection
Interventions
Waterlase Express™, BIOLASE®, Sodium Hypochlorite
Device · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional

Impact of Enhanced Daily Disinfection on Environmental Contamination in Hospital Rooms

NCT05739955
View directory record Official record
Conditions
Disinfection
Interventions
Sani24, Standard EPA-registered disinfectant, Routine Disinfection
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
475 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Health Impact Study of Aquatabs in Tamale, Ghana

NCT00252928
View directory record Official record
Conditions
Diarrhea
Interventions
Sodium dichloroisocyanurate (NaDCC) tablets, Placebo
Other
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
Not listed
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2007 · Synced Sep 18, 2026, 6:53 PM EDT
Completed No phase listed Observational

Effect of Genetic Differences on Levels of Water Disinfection Byproducts in Blood After Showering

NCT00340535
View directory record Official record
Conditions
Normal Physiology
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2021 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment

NCT06110494
View directory record Official record
Conditions
Apical Periodontitis, Pulp Disease, Dental
Interventions
Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl, supplementary irrigation
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Sep 18, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional

Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

NCT06569329
View directory record Official record
Conditions
Dental Pulp Necroses
Interventions
GentleWave System Root Canal Therapy, EdgePro Laser Root Canal Therapy, The ProUltra Piezo Ultrasonic with EndoUltra Tips Root Canal Therapy
Device
Lead sponsor
Abhishek Parolia
Other
Eligibility
18 Years to 95 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Wells and Enteric Disease Transmission

NCT04826991
View directory record Official record
Conditions
Diarrhea, Gastrointestinal Infection, Respiratory Viral Infection, Waterborne Diseases
Interventions
Active UV Device, Inactive UV Device
Device
Lead sponsor
Temple University
Other
Eligibility
6 Months to 59 Months
Enrollment
908 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates

NCT06824350
View directory record Official record
Conditions
Sepsis, Neonatal Mortality, Antibiotic Resistant Infection, Enteric Infections, Serious Bacterial Infection
Interventions
chlorination for water disinfection and surface disinfection, infection prevention and control messaging
Device · Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
Not listed
Enrollment
45,450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 18, 2026, 6:53 PM EDT
Not yet recruiting Not applicable Interventional

Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment

NCT07469150
View directory record Official record
Conditions
Apical Periodontitis
Interventions
GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
16 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional

The Impact of Patient Motivational Dialogue (PMD) on Patient Self-advocacy for Hand Hygiene

NCT04360057
View directory record Official record
Conditions
Hand Disinfection
Interventions
PMD, PMDPlus
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
3 Years to 85 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 18, 2026, 6:53 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets

NCT02316652
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Scaling and root planing, Scaling and root planing with solution
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Phase 4 Interventional

Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)

NCT04018482
View directory record Official record
Conditions
Age-related Macular Degeneration, Diabetic Retinopathy, Diabetic Macular Edema
Interventions
Povidone Iodine, Hypochlorous Acid
Other
Lead sponsor
California Retina Consultants
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional

A Randomized Controlled Trial of a School Disinfection and Hand Hygiene Program

NCT00514670
View directory record Official record
Conditions
Respiratory Infections, Gastrointestinal Diseases
Interventions
Alcohol-based hand sanitizer & quaternary ammonium wipes
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Not listed
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 9, 2007 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Phase 3 Interventional

Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections

NCT06702878
View directory record Official record
Conditions
Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents
Interventions
nasal antimicrobial photodisinfection therapy
Combination Product
Lead sponsor
Ondine Biomedical Inc.
Industry
Eligibility
18 Years and older
Enrollment
4,787 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
14
States / cities
Englewood, Colorado • Brandon, Florida • Largo, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Phase 3 Interventional

Hypochlorous Acid Disinfection Prior to Cataract Surgery

NCT04568213
View directory record Official record
Conditions
Cataract, Endophthalmitis
Interventions
Hypochlorous Acid Gel 0.02%
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 95 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional Results available

Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection

NCT03349268
View directory record Official record
Conditions
Healthcare Associated Infection, Clostridium Difficile Infection, Infection Due to Multidrug Resistant Bacteria
Interventions
Pulsed xenon ultraviolet (PX-UV) Device, Sham Device
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
25,732 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 18, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Root Canal Desinfection Protocols

NCT07439614
View directory record Official record
Conditions
Periapical Periodontitis
Interventions
Desinfection device, Analytical microbiological methods
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional

Measuring the Impact of an Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms

NCT05560321
View directory record Official record
Conditions
Disinfection
Interventions
Sani24, Routine Disinfection
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Sep 18, 2026, 6:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia

NCT05172752
View directory record Official record
Conditions
Disinfection By-products
Interventions
Citizen Scientist Training Program, Stakeholder Consultation Core Program
Other
Lead sponsor
Anna Hoover
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 18, 2026, 6:53 PM EDT
Completed Not applicable Interventional Results available

Passive Disinfection Cap Compliance Study

NCT03391960
View directory record Official record
Conditions
Infection, Hospital
Interventions
Passive disinfection device
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Maplewood, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 18, 2026, 6:53 PM EDT
Completed No phase listed Observational

Interactions of Environmental and Human Microbial Communities in a Pediatric Oncology Hospital

NCT02948335
View directory record Official record
Conditions
Infection
Interventions
Not listed
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
Not listed
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Sep 18, 2026, 6:53 PM EDT
Completed No phase listed Observational

Surgical Prep in Hand Surgery

NCT01676051
View directory record Official record
Conditions
Surgical Scrubbing, Disinfection
Interventions
Skin culture
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 89 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced Sep 18, 2026, 6:53 PM EDT