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ClinicalTrials.gov public records Last synced Oct 20, 2026, 10:13 PM EDT

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Showing 313–336 of 460 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Drug Abuse Clear all
Completed Phase 2 Interventional

Brief Intervention for Drug Misuse in the Emergency Department

NCT01124591
View directory record Official record
Conditions
Substance Abuse Detection, HIV, Hepatitis B, Hepatitis C, Brief Intervention, HIV Infections
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
1,030 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 20, 2026, 10:13 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I

NCT02709954
View directory record Official record
Conditions
Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
Interventions
Active inhaled delta-9-THC, Placebo, Active Oral Ethanol
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Not applicable Interventional Results available

Trial of Adherence App for Buprenorphine Treatment (TAAB) Study

NCT03779997
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Video-based DOT Application
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Oct 20, 2026, 10:13 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Age-dependent Effects of Smoked and Oral Delta-9-THC

NCT05865470
View directory record Official record
Conditions
Pain, Abuse, Drug, Intoxication; Cannabinoids
Interventions
Cannabis, Dronabinol, Smoked Placebo, Oral Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep

NCT00893269
View directory record Official record
Conditions
Marijuana Dependence
Interventions
eszopiclone, Placebo, ramelteon, zolpidem
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2013 · Synced Oct 20, 2026, 10:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development

NCT01020669
View directory record Official record
Conditions
Drug Abuse, Prenatal Drug Exposure
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 20, 2026, 10:13 PM EDT
Not listed Not applicable Interventional

University of Houston Drug Abuse Research Development Program II

NCT03557632
View directory record Official record
Conditions
Heroin Dependence
Interventions
Virtual Reality Cue Exposure Therapy, Relapse Prevention Drug Education
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 64 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2018 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 3 Interventional

Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics - 1

NCT00033007
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Behavior Therapy
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 99 Years
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2003
U.S. locations
11
States / cities
Los Angeles, California • Alamosa, Colorado • Littleton, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 20, 2026, 10:13 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Multiple Behavior Screening, Brief Intervention and Referral to Treatment (SBIRT) Model of Drug Abuse in Primary Care

NCT01439334
View directory record Official record
Conditions
Drug Abuse
Interventions
MB-SBIRT (multiple behavior screening, brief intervention and referral to treatment) Online Program Brief, MB-SBIRT (multiple behavior screening, brief intervention and referral to treatment) Online Program Extended Length, MB-SBIRT (multiple behavior screening, brief intervention and referral to treatment) Control
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 25 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 23, 2011 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use

NCT01621334
View directory record Official record
Conditions
Domestic Violence, Substance Abuse
Interventions
Motivational Enhancement Therapy, Educational information
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Male only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 18, 2012 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Not applicable Interventional

Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders

NCT03241771
View directory record Official record
Conditions
Opioid Abuse, Overdose, Risk Behavior
Interventions
Naloxone Navigator 1.0
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Oct 20, 2026, 10:13 PM EDT
Withdrawn Phase 1 Interventional

Trial of Computerized MET for Adolescent Substance Use

NCT01784653
View directory record Official record
Conditions
Drug Abuse, Alcohol Abuse, Nicotine Dependence
Interventions
iMET, MET
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Oct 20, 2026, 10:13 PM EDT
Completed No phase listed Observational

Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms

NCT01603992
View directory record Official record
Conditions
Cannabis Abuse, Cannabis Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
822 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
3
States / cities
Baltimore, Maryland • Catonsville, Maryland • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Pharmacokinetics and Pharmacodynamics of Hemp-based Topical Cannabinoid Products

NCT04741477
View directory record Official record
Conditions
Cannabis, Drug Effect
Interventions
CBD, THC, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 10, 2023 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Enhancing Medication-based Analgesia in Humans

NCT02901275
View directory record Official record
Conditions
Pain, Cannabis, Opioid Use, Unspecified
Interventions
Within-subject test of blinded study medications
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 20, 2026, 10:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Influence of Nicotine on Cognitive Function in Schizophrenic Patients With and Without Comorbid Drug Dependence

NCT01037075
View directory record Official record
Conditions
Schizophrenia, Drug Abuse/Dependency
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
2
States / cities
Baltimore, Maryland • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Oct 20, 2026, 10:13 PM EDT
Completed No phase listed Observational

Parental Involvement and Children's Extra-Familial Contexts

NCT00538252
View directory record Official record
Conditions
Prevention of Drug Abuse Risk
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
2 Years to 3 Years
Enrollment
731 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 11, 2013 · Synced Oct 20, 2026, 10:13 PM EDT
Completed No phase listed Observational

Fetal Neurobehavior in Poly-drug Dependent Women

NCT00653692
View directory record Official record
Conditions
Poly Drug Exposed Pregnancies
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 21, 2013 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Administration of Clomiphene: Short and Long Term Metabolism in an Anti-Doping Setting

NCT03028532
View directory record Official record
Conditions
Sports Drug Abuse, Abuse of Steroids or Hormones
Interventions
Clomid
Drug
Lead sponsor
Stuart Willick
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Oct 20, 2026, 10:13 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Brain Glutamate Receptors and Cocaine Dependence

NCT00951314
View directory record Official record
Conditions
Drug Abuse, Cocaine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Not applicable Interventional

PATH For Triples Study: Medication and Lifestyle Adherence for HIV+ Patients

NCT02185144
View directory record Official record
Conditions
HIV
Interventions
PATH For Triples, Treatment as Usual
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 4, 2019 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder

NCT00118534
View directory record Official record
Conditions
Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
Interventions
Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 80 Years
Enrollment
943 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
11
States / cities
Tuscaloosa, Alabama • San Diego, California • Washington D.C., District of Columbia + 8 more
Source: ClinicalTrials.gov public record
Updated May 5, 2014 · Synced Oct 20, 2026, 10:13 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Medications for Stopping Cocaine Dependence and Preventing Relapse

NCT00218023
View directory record Official record
Conditions
Cocaine Abuse, Cocaine-Related Disorders
Interventions
Modafinil, Levodopa/Carbidopa, Naltrexone HCl, Placebo, Motivational Interviewing (MI), Contingency management (CM), Cognitive-Behavioral Therapy (CBT)
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 55 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 20, 2026, 10:13 PM EDT
Not listed Phase 4 Interventional

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

NCT03781765
View directory record Official record
Conditions
ADHD, Attention Deficit Hyperactivity Disorder
Interventions
Methylphenidate, Atomoxetine
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
7 Years to 12 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 20, 2026, 10:13 PM EDT