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Showing 1–24 of 97 matching trials from the live ClinicalTrials.gov search.
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Active, not recruiting Phase 3 Interventional Accepts healthy volunteers Results available

Opioid Analgesic Reduction Study

NCT04452344
View directory record Official record
Conditions
Opioid Use
Interventions
opioid-containing analgesic, two over-the-counter analgesics
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
1,815 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
5
States / cities
Chicago, Illinois • Baltimore, Maryland • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)

NCT04134767
View directory record Official record
Conditions
Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis), Overdose, Drug, Opioid Use
Interventions
Health Linkage, Overdose Education
Behavioral
Lead sponsor
April M Young
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional

Impact of Information Prescriptions on Medication Adherence in Emergency Department (ED) Patients

NCT01174706
View directory record Official record
Conditions
Patient Compliance, Medication Adherence, Medication Non-Adherence
Interventions
Information prescriptions
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
3,940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
Baltimore, Maryland • Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 20, 2018 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tear Film Break-up Time After Instillation of Artificial Tears

NCT00681265
View directory record Official record
Conditions
Keratoconjunctivitis Sicca
Interventions
glycerin, polyethylene glycol 400/propylene glycol
Drug
Lead sponsor
Calm Water Therapeutics LLC
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 25, 2012 · Synced Jul 21, 2026, 4:00 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

Effects of Dietary Conditions on Drug Response

NCT04315961
View directory record Official record
Conditions
Healthy
Interventions
Blinded drug dose conditions
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 45 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 8, 2024 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Effect of Over-the-counter Analgesics on Postoperative Pain

NCT06948513
View directory record Official record
Conditions
Pain Management
Interventions
Naproxen, Acetaminophen (Standard of Care), ibuprofen
Drug
Lead sponsor
Zitelli & Brodland Skin Cancer Center
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Clairton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Opioid Prescribing Nudge

NCT04069403
View directory record Official record
Conditions
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior, Benzodiazepine Abuse, Benzodiazepine Dependent
Interventions
Automated Reports on prescription patterns for their patients
Other
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
427 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops

NCT00610480
View directory record Official record
Conditions
Dry Eye Disease
Interventions
1st visit Optive, then 2nd visit Systane, 1st visit Systane, then 2nd visit Optive
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Jul 21, 2026, 4:00 PM EDT
Not listed Not applicable Interventional

Comparison of Prescription Lidocaine Patch to Over the Counter Lidocaine Patch and Placebo for Back Pain and Arthritis

NCT02749123
View directory record Official record
Conditions
Back Pain, Arthritis
Interventions
lidocaine 5% patch, lidocaine 3.6%, menthol 1.25%, Placebo
Drug
Lead sponsor
J.A.R. Laboratories
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Barrington, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2016 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mobile Application for Prescription Drug-Abuse Education (MAPDE)

NCT03165175
View directory record Official record
Conditions
Prescription Drug Abuse (Not Dependent)
Interventions
prescription drug-abuse education smartphone application
Behavioral
Lead sponsor
Naval Health Research Center
Federal
Eligibility
18 Years to 55 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2019 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Phase 3 Interventional Results available

Actual Use Trial of Ibuprofen 400 mg

NCT02294019
View directory record Official record
Conditions
Patient Compliance
Interventions
Ibuprofen 400 mg caplet
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
738 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
25
States / cities
Hoover, Alabama • McCalla, Alabama • Mesa, Arizona + 22 more
Source: ClinicalTrials.gov public record
Updated May 29, 2016 · Synced Jul 21, 2026, 4:00 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Treatment of Androgenetic Alopecia in Males With Theradome™ LH80 PRO

NCT02528552
View directory record Official record
Conditions
Androgenetic Alopecia
Interventions
LH80 PRO, Sham Device
Device
Lead sponsor
Theradome, Inc.
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
4
States / cities
Los Angeles, California • Newnan, Georgia • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2016 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study to Evaluate the Efficacy of an Over-the-counter (OTC) Sunscreen Lip Balm

NCT05082376
View directory record Official record
Conditions
Sunscreening Agents
Interventions
CLM Original
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Jul 21, 2026, 4:00 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

DILIN - Prospective Study

NCT00345930
View directory record Official record
Conditions
Liver Diseases
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
2 Years and older
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2028
U.S. locations
6
States / cities
Los Angeles, California • Indianapolis, Indiana • Bethesda, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 21, 2026, 4:00 PM EDT
Not listed Not applicable Interventional

Assessment of the Effects on the Skin Microbiome of Amending an Over-the-counter Eczema Product With Activated Oil (AO)

NCT05413395
View directory record Official record
Conditions
Eczema
Interventions
topical colloidal oatmeal formulation with a modified plant oil, topical colloidal oatmeal formulation
Other
Lead sponsor
GlycosBio, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 4, 2022 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Phase 2 Interventional

Treatment of Multiple Sclerosis Using Over the Counter Inosine

NCT00067327
View directory record Official record
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
Inosine
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 16, 2006 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Not applicable Interventional

Comparison of Two Over the Counter Intravaginal Devices for the Treatment of Stress Urinary Incontinence

NCT06698627
View directory record Official record
Conditions
Stress Urinary Incontinence in Women
Interventions
Daily Disposable Continence Device, Monthly Disposable Continence Device
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Phase 3 Interventional

To Assess the Efficacy of Over-the-counter Analgesics in the Prevention/Treatment of Transient Post-dose Symptoms Following Zoledronate Infusion in Post-menopausal Women

NCT00145275
View directory record Official record
Conditions
Osteopenia
Interventions
zoledronic acid
Drug
Lead sponsor
Novartis
Industry
Eligibility
45 Years to 75 Years · Female only
Enrollment
455 participants
Timeline
2004 – 2005
U.S. locations
6
States / cities
Unavailable, Georgia • Unavailable, Illinois • Unavailable, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2012 · Synced Jul 21, 2026, 4:00 PM EDT
Completed No phase listed Observational

Covid Flu A/B and RSV 4 in 1 Diagnostic Test

NCT07308158
View directory record Official record
Conditions
Influenza A, Influenza B, COVID - 19, RSV
Interventions
Investigational Flu A/B Covid-19 and RSV Diagnostic Test
Diagnostic Test
Lead sponsor
iHealth Labs inc
Industry
Eligibility
6 Months and older
Enrollment
1,119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
21
States / cities
Birmingham, Alabama • Trussville, Alabama • Dublin, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 21, 2026, 4:00 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Self-efficacy-based Auditory Rehabilitation With Over-the-Counter Hearing Aids

NCT06560918
View directory record Official record
Conditions
Hearing Loss, Sensorineural
Interventions
hearing aids
Device
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 85 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 4:00 PM EDT
Completed No phase listed Observational

Implementation and Evaluation of SBIRT

NCT03560076
View directory record Official record
Conditions
Substance Use Disorders
Interventions
SBIRT Training and Implementation Strategies
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
2,562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Jul 21, 2026, 4:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparing Over-the-counter Dry Mouth Remedies After Radiation

NCT00595933
View directory record Official record
Conditions
Xerostomia
Interventions
sugar-free chewing gum, chewing gum, mouth rinse, mouth spray
Other · Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
13 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 6, 2022 · Synced Jul 21, 2026, 4:00 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Assessing Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies

NCT06864273
View directory record Official record
Conditions
Bilateral Hearing Loss, Health Services Research
Interventions
Pharmacy Technician Educational Training
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Jul 21, 2026, 4:00 PM EDT
Completed No phase listed Observational

A Study to Investigate Use Patterns and Safety in Simulated Actual Over-the-counter (OTC) Use of Rabeprazole Sodium for the Treatment of Heartburn Symptoms

NCT01286194
View directory record Official record
Conditions
Frequent Heartburn
Interventions
Rabeprazole sodium
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
33
States / cities
Scottsdale, Arizona • Griffin, Georgia • Lawrenceville, Georgia + 29 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2011 · Synced Jul 21, 2026, 4:00 PM EDT