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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:54 AM EST

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Showing 1–24 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: Electronic Cigarette Use
Interventions: Health Assessments; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
Interventions: Vaping Device Labeling; Other
Lead sponsor: University of Southern California; Other
Eligibility: 11 Years to 19 Years
Enrollment: 3,048 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: E-cigarette Use, Vaping
Interventions: Peer Messaging, Peer Coaching via Text, Gamification, E-Cigarette Cessation Materials; Behavioral · Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 19 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Nicotine Dependence
Interventions: e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Dependence
Interventions: Nicotine, Vaporizer Device, Salt-HIgh Nicotine Unflavored (Product B), Free-Low Nicotine Tobacco Flavored (Product C), Salt-High Nicotine Tobacco Flavored (Product D); Drug · Device
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Nicotine Dependence, Tobacco Use Disorder
Interventions: Varenicline Pill, Contingency management, Counseling; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 40 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 3
States / cities: Charleston, South Carolina • Lancaster, South Carolina • Pickens, South Carolina

Conditions: Smoking
Interventions: P3L, VUSE, CC; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 19 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Nicotine Addiction, Vaping
Interventions: Nicotine pod, Placebo pod; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Energy Intake, Food Intake, E-Cig Use, Appetite
Interventions: Vaping condition, Control condition; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking Cessation
Interventions: BIDI Stick e-cigarette; Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Nicotine Use Disoder, Opioid Use Disorder
Interventions: Sweet-cooling, Sweet non-cooling EC flavor, Tobacco flavor EC; Drug
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 21 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions: Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 45 Years
Enrollment: 142 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Vaping, Vaping Teens, Nicotine Dependence
Interventions: QuitVaping, This is Quitting (TIQ); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 19 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: Electronic Cigarette #1, Electronic Cigarette #2; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Lakewood, Colorado

Conditions: Alcohol Use, E-cigarette Use, Cigarette Use
Interventions: Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks; Behavioral
Lead sponsor: Mark J Rzeszutek, PhD; Other
Eligibility: 21 Years and older
Enrollment: 737 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Healthy
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking
Interventions: E-cigarette Switching, Financial Incentives; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 100 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Vaping, E Cig Use, Prescription Drug Misuse
Interventions: School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse; Behavioral
Lead sponsor: Christopher Williams; Industry
Eligibility: 7 Years to 11 Years
Enrollment: 3,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Healthy Lifetime Non-smokers
Interventions: Propylene Glycol, vegetable glycerin, PG+VG; Other
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: E-Cig Use, Vaping
Interventions: videogame, treatment as usual; Device · Other
Lead sponsor: Yale University; Other
Eligibility: 11 Years to 17 Years
Enrollment: 287 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Milford, Connecticut

Conditions: Smoking, Smoking Behaviors, Nicotine Dependence
Interventions: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: E-cigarette Use
Interventions: C-11 labeled nicotine, PET/CT imaging; Drug · Radiation
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 80 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Dependence, Cigarettes
Interventions: AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 14 Years to 20 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions: Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mango ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mango ENDS, Switch to Dual-use of JUUL 5% and UB of Combustible Cigarette, Tobacco/Nicotine Abstention, Usual Brand of cigarettes; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 279 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 5
States / cities: Little Rock, Arkansas • Rogers, Arkansas • St Louis, Missouri + 2 more

Search by objective public record fields.

Effects of E-cigarette Use on Health

Nicotine and Cannabis Vape Labeling Experiment - Spring 2025

Vaper to Vaper: A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

E-cigarette Cessation in Adults Who Co-use Cannabis

User Acceptability of a Nicotine Lactate Delivery System (P3L)

Acute Effects of Vaping Nicotine on Cognition in Young Adults

The Acute Effect of Vaping on Food Intake

Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

Effects of Electronic Cigarette Use on the Lungs

Behavioral Intervention for Youth to Promote Vaping Cessation

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

Biology of the Oral Epithelium of E-Cigarette Smokers

E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services

A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

A Virtual Reality Videogame for E-cigarette Prevention in Teens

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS