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ClinicalTrials.gov public records Last synced Oct 24, 2026, 3:49 PM EDT

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Showing 1–24 of 92 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: E-cigarette Smokers Clear all
Completed Not applicable Interventional Results available

E-cigarettes for Harm Reduction in Adults With Asthma

NCT05278065
View directory record Official record
Conditions
Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD170501: Study to Assess Biomarkers of Tobacco Exposure in Smokers During In-Clinic Confinement Switch to an Electronic Cigarette

NCT03170674
View directory record Official record
Conditions
Smoking
Interventions
FT21039, FT21092, FT21018
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
2
States / cities
Overland Park, Kansas • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 8, 2017 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS

NCT04107779
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions
Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mango ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mango ENDS, Switch to Dual-use of JUUL 5% and UB of Combustible Cigarette, Tobacco/Nicotine Abstention, Usual Brand of cigarettes
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
279 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Little Rock, Arkansas • Rogers, Arkansas • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Oct 24, 2026, 3:49 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

NCT03943706
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 19, 2020 · Synced Oct 24, 2026, 3:49 PM EDT
Not listed Not applicable Interventional

The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment

NCT04014322
View directory record Official record
Conditions
Tobacco Smoking, Psychiatric Disorders
Interventions
E-cigarette
Other
Lead sponsor
Fordham University
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 18, 2023 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects Among Smokers Who Use and Do Not Use E-Cigarettes

NCT03511001
View directory record Official record
Conditions
Toxicant Exposure
Interventions
E-Cigarette Vs. Smoking as Usual
Other
Lead sponsor
California State University, San Marcos
Other
Eligibility
21 Years and older
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
San Marcos, California • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users

NCT03710590
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
ECIG Lab Session 15 watts, 10 mg nicotine, ECIG Lab Session 15 watts, 15 mg nicotine, ECIG Lab Session 15 watts, 30 mg nicotine, ECIG Lab Session 30 watts, 10 mg nicotine, ECIG Lab Session 30 watts, 15 mg nicotine, ECIG Lab Session 30 watts, 30 mg nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Results available

Changes in Biomarkers Associated With Use of Electronic Cigarettes

NCT03084315
View directory record Official record
Conditions
Biomarkers
Interventions
E-Cig Zero Nicotine, E-Cig 24mg Nicotine
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarette Use on the Lungs

NCT02596685
View directory record Official record
Conditions
Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions
Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 45 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Nicotine Withdrawal

NCT03098004
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
e-Cigarette
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2023 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

NCT05023096
View directory record Official record
Conditions
Electronic Nicotine Delivery System Flavors
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Phase 3 Interventional

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers

NCT06435221
View directory record Official record
Conditions
Smoking Cessation, Vaping Cessation
Interventions
Cytisinicline
Drug
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
29
States / cities
Mobile, Alabama • Tempe, Arizona • Little Rock, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

JUUL vs. Mod E-cigarette Study

NCT04237272
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Pod System E-cig, Customizable Tank E-cig, Control
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Oct 24, 2026, 3:49 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Investigation of the Impact of Smoking Status on Allergen-induced Nasal Airway Inflammation Using a Cat Hair (Felis Domesticus) Extract Nasal Allergen Challenge Model

NCT03031145
View directory record Official record
Conditions
Tobacco Smoking, Healthy Participants, E-cigarette Smokers
Interventions
Felis Domesticus
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 7, 2021 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes

NCT02210754
View directory record Official record
Conditions
Smoking
Interventions
blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle), blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin/PG vehicle), Marlboro Cigarette
Other
Lead sponsor
Lorillard Tobacco Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 7, 2014 · Synced Oct 24, 2026, 3:49 PM EDT
Not listed Not applicable Interventional

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

NCT05327439
View directory record Official record
Conditions
Smoking, Cigarette, Nicotine Dependence
Interventions
Nicotine (electronic cigarette), Nicotine (nicotine pouch)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD170303: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes

NCT03234010
View directory record Official record
Conditions
Smoking
Interventions
FT21092, FT21093, FT21096, FT21097
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Results available

Quit or Switch: E-cigarette Study

NCT05525078
View directory record Official record
Conditions
Tobacco Use
Interventions
e-cigarette, Nicotine patch, Nicotine lozenge
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

NCT03596034
View directory record Official record
Conditions
Tobacco Use, Nicotine Dependence, Other Tobacco Product, Tobacco Smoking
Interventions
JUUL 5%, Virginia Tobacco, ENDS product
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

NCT04123041
View directory record Official record
Conditions
Electronic Cigarette Use, Tobacco Smoking
Interventions
JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
Kansas City, Kansas • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

NCT04879225
View directory record Official record
Conditions
Cigarette Smoking, Vaping
Interventions
Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids, All e-liquid flavors
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers

NCT02648178
View directory record Official record
Conditions
Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
Interventions
HALO
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Oct 24, 2026, 3:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes

NCT04019626
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Continue-smoking, myblu Tobacco 2.5%, myblu Tobacco 4.0%, myblu Honeymoon 2.5%, myblu Honeymoon 4.0%, JUUL 5%
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
21 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 24, 2026, 3:49 PM EDT