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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Elevated Intracranial Pressure Clear all
Suspended Not applicable Interventional

Operative Procedures Vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial

NCT02513914
View directory record Official record
Conditions
Pseudotumor Cerebri, Idiopathic Intracranial Hypertension (IIH)
Interventions
Dural Venous Sinus Stenting, Cerebrospinal Fluid Shunting
Device
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Phoenix, Arizona • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Jul 22, 2026, 2:21 AM EDT
Not yet recruiting Phase 4 Interventional

Tirzepatide in Idiopathic Intracranial Hypertension Trial

NCT07191873
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension (IIH)
Interventions
Tirzepatide, Tirzepatide Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Idiopathic Intracranial Hypertension Treatment Trial

NCT01003639
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension
Interventions
Acetazolamide, Placebo, Formal weight loss counselling program
Drug · Behavioral
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 60 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
39
States / cities
Birmingham, Alabama • Los Angeles, California • Waterbury, Connecticut + 31 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Not applicable Interventional

Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement

NCT01863381
View directory record Official record
Conditions
Hydrocephalus, Idiopathic Intracranial Hypertension, Pseudotumor Cerebri
Interventions
Tympanic membrane displacement (TMD), DPOAE
Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2017 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

3-D Transcranial Ultrasound Analysis Study

NCT00239525
View directory record Official record
Conditions
Cerebrovascular Accident, Intracranial Hypertension
Interventions
3-D ultrasound scanner, Perflutren Protein-Type A Microspheres for injection
Device · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 10, 2014 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Phase 3 Interventional

Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure

NCT01111682
View directory record Official record
Conditions
Traumatic Brain Injury, Elevated Intracranial Pressure
Interventions
Mannitol, Hypertonic Saline
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 4, 2013 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Ocular Screening in Children and Young Adults at Risk for Increased Intracranial Pressure

NCT03286426
View directory record Official record
Conditions
Intracranial Pressure Increase
Interventions
Pictor
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
Up to 21 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Jul 22, 2026, 2:21 AM EDT
Withdrawn Not applicable Interventional

Osmotic Therapy for Treatment of Intracranial Hypertension for Traumatic Brain Injury

NCT01215019
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Mannitol, NaCl
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Jul 22, 2026, 2:21 AM EDT
Completed No phase listed Observational

Observational Study of Cortical Spreading Depression in Human Brain Trauma

NCT00803036
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 80 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
4
States / cities
Miami, Florida • Cincinnati, Ohio • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Jul 22, 2026, 2:21 AM EDT
Completed No phase listed Observational

Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx

NCT04490005
View directory record Official record
Conditions
Acute Brain Injury, Pupillary Reflex Impaired
Interventions
pupillometry
Other
Lead sponsor
University of Milano Bicocca
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
San Francisco, California • Baltimore, Maryland • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 24, 2023 · Synced Jul 22, 2026, 2:21 AM EDT
Completed No phase listed Observational

Automated Chest Physiotherapy to Improve Outcomes in Neuro

NCT00571623
View directory record Official record
Conditions
Brain Injury, Intracranial Hypertension
Interventions
Chest Physiotherapy
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
3
States / cities
Mission Viejo, California • Durham, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 8, 2014 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional

Effects of Head Elevation on Intracranial Pressure in Children

NCT00636376
View directory record Official record
Conditions
Head Injury
Interventions
Place HOB in alternate positions from 0-50 degrees.
Procedure
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Up to 18 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 20, 2008 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure

NCT03212976
View directory record Official record
Conditions
Intracranial Pathology, Intracranial Hypertension
Interventions
Phase contrast magnetic resonance imaging
Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 4, 2024 · Synced Jul 22, 2026, 2:21 AM EDT
Recruiting No phase listed Observational

Advanced Neuroimaging in Idiopathic Intracranial Hypertension

NCT06950099
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension (IIH), Glymphatic System
Interventions
Not listed
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Phase 2 Interventional Results available

Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)

NCT00974259
View directory record Official record
Conditions
Severe Traumatic Brain Injury
Interventions
Management protocol based on pBrO2 and ICP values., Management protocol based on ICP values only.
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
10
States / cities
Miami, Florida • Durham, North Carolina • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Jul 22, 2026, 2:21 AM EDT
Not listed No phase listed Observational

Validation of Non-Invasive Intracranial Pressure (ICP) Monitoring Device

NCT03865576
View directory record Official record
Conditions
Intracranial Hypertension, Abnormality of Intracranial Pressure
Interventions
Non-invasive ICP measurement
Diagnostic Test
Lead sponsor
Boston Neurosciences
Industry
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
4
States / cities
Phoenix, Arizona • Atlanta, Georgia • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Jul 22, 2026, 2:21 AM EDT
Recruiting No phase listed Observational

Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients

NCT06511804
View directory record Official record
Conditions
Brain Injuries, Intracranial Pressure Increase, Monitoring
Interventions
Intracranial Pressure Noninvasive Monitoring
Device
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 100 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated Phase 3 Interventional Results available

Surgical Idiopathic Intracranial Hypertension Treatment Trial

NCT03501966
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension
Interventions
Acetazolamide, Optic Nerve Sheath Fenestration, Ventriculoperitoneal CSF Shunting
Drug · Procedure
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
18 Years to 63 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
33
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Jul 22, 2026, 2:21 AM EDT
Completed No phase listed Observational

ShuntCheck Performance Characteristics in Asymptomatic Pseudotumor Cerebri Patients

NCT04309383
View directory record Official record
Conditions
Pseudotumor Cerebri
Interventions
ShuntCheck
Diagnostic Test
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
12 participants
Timeline
2019 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jul 22, 2026, 2:21 AM EDT
Completed No phase listed Observational

The Use of Near Infrared Spectroscopy (NIRS) to Estimate Intracranial Pressure (ICP)

NCT01850069
View directory record Official record
Conditions
Intracranial Hypertension
Interventions
Not listed
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional

The Effects of MAP and EtCO2 on Venous Sinus Pressures

NCT03867461
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension
Interventions
Venous Sinus Stenting, Adjustment to end-tidal carbon dioxide concentrations ( 38-40 mmHg range), Adjustment to Mean Arterial Pressure (100-110 mmHg range), Adjustment to Mean Arterial Pressure (60-80 mmHg range), Adjustment to end-tidal carbon dioxide concentrations (24-26 mmHg range)
Procedure · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Jul 22, 2026, 2:21 AM EDT
Withdrawn No phase listed Observational

Disc Edema in Patients With Chronic Kidney Disease

NCT00769834
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Not listed
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 27, 2018 · Synced Jul 22, 2026, 2:21 AM EDT
Terminated No phase listed Observational

Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients

NCT00125229
View directory record Official record
Conditions
Traumatic Brain Injury, Intracranial Hypertension
Interventions
Mannitol, Hypertonic Saline
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2012 · Synced Jul 22, 2026, 2:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vasopressin in Intraabdominal Pressure Elevation

NCT03707054
View directory record Official record
Conditions
Intracranial Pressure Increase, Abdominal Compartment Syndrome
Interventions
Study Arm
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 72 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 22, 2026, 2:21 AM EDT