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ClinicalTrials.gov public records Last synced Oct 1, 2026, 11:09 PM EDT

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Showing 25–48 of 557 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Emotional Depression Clear all
Active, not recruiting Not applicable Interventional

Treatment for Migraine and Mood

NCT05576467
View directory record Official record
Conditions
Migraine, Depressive Symptoms
Interventions
MBCT-Telephone, MBCT-Video, Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
Amanda Shallcross
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
The Bronx, New York • Winston-Salem, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Education Program for Family Caregivers

NCT00764647
View directory record Official record
Conditions
Stress
Interventions
Education program for family caregivers of frail elders
Behavioral
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 1, 2026, 11:09 PM EDT
Recruiting Phase 1 Interventional

Psilocybin as a Novel Therapy for Residual Anhedonia

NCT07607938
View directory record Official record
Conditions
Anhedonia, Emotional Blunting
Interventions
Psilocybin, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 1, 2026, 11:09 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Online System for Identifying and Addressing Teen Depression in Primary Care

NCT04489485
View directory record Official record
Conditions
Major Depression, Dysthymia, Depressive Symptoms
Interventions
Teen Depression Module used for care
Behavioral
Lead sponsor
Total Child Health, Inc.
Industry
Eligibility
12 Years to 99 Years
Enrollment
580 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality (VR) for Stress Management

NCT06970652
View directory record Official record
Conditions
Stress, Resilience, Quality of Life, Depressive Symptoms, Anxiety, Sleep, Physical Activity
Interventions
virtual reality
Device
Lead sponsor
City University of New York, School of Public Health
Other
Eligibility
18 Years to 29 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 1, 2026, 11:09 PM EDT
Completed No phase listed Observational

MRI Study of Brain Activity and Risk for Depression in Adolescents

NCT00047944
View directory record Official record
Conditions
Involutional Depression, Anxiety Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
10 Years to 55 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 1, 2026, 11:09 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

One Talk at a Time: A Racial-ethnic Socialization Intervention for Diverse Families

NCT05454293
View directory record Official record
Conditions
Depressive Symptoms, Anxiety Disorders and Symptoms, Behavioral Symptoms, Ethnic-Racial Socialization
Interventions
One Talk at a Time: Race, One Talk at a Time: General
Other
Lead sponsor
University of North Carolina, Greensboro
Other
Eligibility
Not listed
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Evaluating a Mobile App for Students Seeking Care for Depression and Anxiety at Harvard University Health Services

NCT03552900
View directory record Official record
Conditions
Depression, Anxiety
Interventions
7cups Mobile App, Bliss
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 5, 2021 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Reducing Hospital Readmissions in Patients With Depressive Symptoms

NCT01840826
View directory record Official record
Conditions
Depression
Interventions
RED-D Care Management
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
709 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

To Increase Psychological Well-being by the Implementation of Forgiveness Education

NCT04403126
View directory record Official record
Conditions
Anger, Depressive Symptoms, Anxiety
Interventions
forgiveness education intervention
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
10 Years to 65 Years
Enrollment
1,300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Preventing Depression in People With Epilepsy: an Extension of Project UPLIFT

NCT01941706
View directory record Official record
Conditions
Epilepsy, Depressive Symptoms, Depression, Seizure Disorder
Interventions
Project UPLIFT
Behavioral
Lead sponsor
Emory University
Other
Eligibility
21 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
4
States / cities
Atlanta, Georgia • Ann Arbor, Michigan • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2014 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents

NCT03626103
View directory record Official record
Conditions
Depressive Disorder, Violence
Interventions
+ Brief ED Intervention (BI), + Text
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
13 Years to 17 Years
Enrollment
620 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
New Haven, Connecticut • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Mindfulness-based Dementia Care Partner Program to Reduce Depressive Symptoms

NCT05617300
View directory record Official record
Conditions
Dementia
Interventions
Mindfulness-Based Dementia Caregiving
Behavioral
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 10, 2025 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Life Experiences in Adolescents and the Development of Skills

NCT04719897
View directory record Official record
Conditions
Depression in Adolescence, Adverse Childhood Experiences
Interventions
FIRST: Repairing Thoughts
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 15 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

The Effect of Questionnaire Content on Measures of Pain Intensity, Magnitude of Disability, and Symptoms of Depression in Patients With Arm Illness

NCT02209259
View directory record Official record
Conditions
Arm Illness
Interventions
PROMIS Upper Extremity Function, Pain intensity, PROMIS depression, Positive affect negative affect scale (PANAS), standard PCS, positively-adjusted version of the PCS
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study of Therapist Guided Activity Practice for Depressive Symptoms

NCT03327259
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Activity Planning, Therapist Guided Activity Practice
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets

NCT05046184
View directory record Official record
Conditions
Major Depressive Disorder, Healthy Controls
Interventions
Ketamine Hydrochloride, Midazolam injection
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Volunteering as an Intervention to Reduce Depression Among Adolescents

NCT03816215
View directory record Official record
Conditions
Depression, Adolescent Behavior, Depressive Symptoms
Interventions
Volunteer experience
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
14 Years to 20 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Middle School Matters Study

NCT01220635
View directory record Official record
Conditions
Depression
Interventions
Positive Thoughts and Actions Program, Individual Support Program
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 14, 2014 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Listening Visits for Emotionally Distressed Mothers of Hospitalized Newborns

NCT03704948
View directory record Official record
Conditions
Nurse Delivered Counseling, Emotional Distress
Interventions
RCT Treatment -Listening Visits delivered by NICU nurse in person, RCT Control Usual mental health care delivered by NICU social workers, Open trial: Listening Visits delivered by a NICU nurse via zoom
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 29, 2023 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Effectiveness and Implementation of a Mindfulness Intervention for Depressive Symptoms Among Adults in a FQHC

NCT03620721
View directory record Official record
Conditions
Depressive Symptoms, Stress, Psychological, Stress, Physiological
Interventions
mindfulness
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

ABSORB (Amount of Blueberries So Older Adults Reap Benefits)

NCT05937165
View directory record Official record
Conditions
Depressive Symptoms, Aging
Interventions
Freeze-dried Blueberry Powder
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional

An IT Approach to Implementing Depression Treatment in Cardiac Patients (iHeart DepCare)

NCT03882411
View directory record Official record
Conditions
Depressive Symptoms, Coronary Heart Disease
Interventions
Electronic shared decision making (eSDM) tool
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
21 Years and older
Enrollment
361 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 1, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Mood in Assisted Living Settings

NCT01763216
View directory record Official record
Conditions
Depressive Symptoms, Clinical Depression
Interventions
Road Tour, Boatload of Crosswords
Other
Lead sponsor
Marianne Smith
Other
Eligibility
55 Years and older
Enrollment
351 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
32
States / cities
Amana, Iowa • Bettendorf, Iowa • Carlisle, Iowa + 17 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2020 · Synced Oct 1, 2026, 11:09 PM EDT