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ClinicalTrials.gov public records Last synced Sep 18, 2026, 11:24 PM EDT

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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Essential Tremor (ET) Clear all
Completed Phase 2 Interventional Results available

A Clinical Study to Evaluate CAD-1883 in Essential Tremor

NCT03688685
View directory record Official record
Conditions
Essential Tremor
Interventions
CAD-1883
Drug
Lead sponsor
Cadent Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
7
States / cities
Anniston, Alabama • Rogers, Arkansas • San Diego, California + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 18, 2026, 11:24 PM EDT
Active, not recruiting Phase 3 Interventional

Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)

NCT06087276
View directory record Official record
Conditions
Essential Tremor
Interventions
60 mg ulixacaltamide, Placebo
Drug
Lead sponsor
Praxis Precision Medicines
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

NCT06293638
View directory record Official record
Conditions
Essential Tremor
Interventions
Alcohol, Alprazolam, Cold Therapy, Peripheral Nerve Stimulation
Drug · Device · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
30 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Completed Not applicable Interventional Results available

Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET)

NCT02909907
View directory record Official record
Conditions
Essential Tremor
Interventions
Botulinum toxin, Placebo
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 7, 2019 · Synced Sep 18, 2026, 11:24 PM EDT
Recruiting Not applicable Interventional

Circadian Adaptive DBS in Essential Tremor

NCT06635811
View directory record Official record
Conditions
Essential Tremor, Essential Tremor (ET), Essential Tremor, Movement Disorders
Interventions
Circadian Adaptive DBS, Conventional DBS
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 89 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Recruiting Not applicable Interventional

Magnetoencephalography (MEG) Pilot Study

NCT07446192
View directory record Official record
Conditions
Essential Tremor
Interventions
MRI and fMRI scans, MEG, Sensor-based motor assessments, Clinical evaluations, Questionnaires and rating scales that
Diagnostic Test · Other
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 84 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Active, not recruiting Not applicable Interventional

RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease

NCT03305588
View directory record Official record
Conditions
Essential Tremor, Parkinson Disease
Interventions
Unframed Virtual Cone
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Trial of Cannabis for Essential Tremor

NCT03805750
View directory record Official record
Conditions
Essential Tremor
Interventions
CBD/THC, Placebo oral capsule
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Sep 18, 2026, 11:24 PM EDT
Recruiting No phase listed Observational

ET Stigma Response to Tremor Suppression

NCT07430761
View directory record Official record
Conditions
Action Tremor, Stigma, Social
Interventions
stereotactic thalamotomy with focused ultrasound
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Terminated Not applicable Interventional

DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET)

NCT05096572
View directory record Official record
Conditions
Essential Tremor
Interventions
VIM Stimulation, PSA Stimulation, VIM+PSA Stimulation
Device
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Sep 18, 2026, 11:24 PM EDT
Completed Not applicable Interventional Results available

Prospective Study for Symptomatic Relief of ET With Cala Therapy

NCT03597100
View directory record Official record
Conditions
Essential Tremor
Interventions
Cala TWO
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
22 Years and older
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
32
States / cities
Phoenix, Arizona • Los Angeles, California • Mountain View, California + 28 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Sep 18, 2026, 11:24 PM EDT
Completed No phase listed Observational

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

NCT01200966
View directory record Official record
Conditions
Essential Tremor
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
21 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 18, 2026, 11:24 PM EDT
Enrolling by invitation Not applicable Interventional

Effects of Stimulation Patterns of Deep Brain Stimulation

NCT02553525
View directory record Official record
Conditions
Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
Interventions
Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
Procedure
Lead sponsor
Duke University
Other
Eligibility
21 Years to 80 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
3
States / cities
Gainesville, Florida • Atlanta, Georgia • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Recruiting Not applicable Interventional

Algorithms for Programming DBS Systems for ET

NCT03984643
View directory record Official record
Conditions
Essential Tremor
Interventions
Vim-Deep Brain Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2031
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Withdrawn Not applicable Interventional

Pre-lemniscal Radiation Deep Brain Stimulation for ET

NCT00634478
View directory record Official record
Conditions
Essential Tremor
Interventions
Pre-lemniscal Radiation Deep Brain Stimulation
Radiation
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
21 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 18, 2026, 11:24 PM EDT
Completed Not applicable Interventional Results available

Wearable Sensor for Responsive DBS for ET

NCT03051178
View directory record Official record
Conditions
Essential Tremor
Interventions
Responsive deep brain stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 18, 2026, 11:24 PM EDT
Completed Phase 2 Interventional Results available

A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)

NCT05122650
View directory record Official record
Conditions
Essential Tremor
Interventions
JZP385, Placebo
Drug · Other
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
41
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 33 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 18, 2026, 11:24 PM EDT
Completed No phase listed Observational Results available

Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET)

NCT01952678
View directory record Official record
Conditions
Essential Tremor, Parkinson's Disease
Interventions
DaTscan™ - Non-Caucasian Participants, DaTscan™ - Caucasian Participants
Other
Lead sponsor
GE Healthcare
Industry
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Marlborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Sep 18, 2026, 11:24 PM EDT
Completed Phase 2 Interventional

Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor

NCT05216250
View directory record Official record
Conditions
Upper Limb Essential Tremor (UL ET)
Interventions
BOTOX, Placebo for BOTOX
Biological · Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 80 Years
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
36
States / cities
Hoover, Alabama • Phoenix, Arizona • Tucson, Arizona + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 18, 2026, 11:24 PM EDT
Recruiting Not applicable Interventional

Directional Versus Nondirectional DBS for ET

NCT04828798
View directory record Official record
Conditions
Essential Tremor
Interventions
Deep brain stimulation of the VIM Thalamic nuclei
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 18, 2026, 11:24 PM EDT
Completed No phase listed Observational

Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.

NCT02132052
View directory record Official record
Conditions
Essential Tremor, Multiple System Atrophy, Corticobasal Degeneration, Supranuclear Palsy, Progressive, Parkinson Disease
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Sep 18, 2026, 11:24 PM EDT