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ClinicalTrials.gov public records Last synced Oct 23, 2026, 9:09 AM EDT

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Showing 73–96 of 139 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extraction, Tooth Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Ridge Preservation With FDBA (Freeze Dried Bone Allograft) Using Dexamethasone vs. Saline

NCT06556095
View directory record Official record
Conditions
Bone Graft, Tooth Extraction
Interventions
Dexamethasone 4mg/ml solution
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Withdrawn Phase 4 Interventional

Use of Remimazolam and Fentanyl for Procedural Sedation in Patients Undergoing Dental Extraction

NCT06793358
View directory record Official record
Conditions
Dental Extraction
Interventions
fentanyl and Remimazolam
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Active, not recruiting Not applicable Interventional Results available

Multicenter Study to Evaluate the Clinical Outcome of PrimeTaper EV Implant in Single Tooth Restorations

NCT05315414
View directory record Official record
Conditions
Jaw, Edentulous, Partially
Interventions
PrimeTaper EV implant
Device
Lead sponsor
Dentsply Sirona Implants and Consumables
Industry
Eligibility
18 Years to 75 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Variability in Analgesic Response to Ibuprofen

NCT06539741
View directory record Official record
Conditions
Impacted Third Molar Tooth, Pain, Acute
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 3 Interventional Results available

A Safety And Efficacy Study of Ibuprofen 250 mg / Acetaminophen 500 mg In The Treatment Of Post-Surgical Dental Pain

NCT02912650
View directory record Official record
Conditions
Post-surgical Pain Following Extraction of Molar Teeth
Interventions
Ibuprofen 250 mg / Acetaminophen 500 mg, Ibuprofen 250 mg, Acetaminophen 650 mg, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 40 Years
Enrollment
568 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 2 Interventional

A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction

NCT00542035
View directory record Official record
Conditions
Dental Pain
Interventions
ARRY-371797, p38 inhibitor; oral, Placebo; oral
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
San Marcos, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy

NCT00755911
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Tissue Repair Cells (TRC), Control
Biological · Device
Lead sponsor
University of Michigan
Other
Eligibility
20 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 3, 2015 · Synced Oct 23, 2026, 9:09 AM EDT
Not listed Not applicable Interventional

Immediate Implant Placement in the Esthetic Zone

NCT01533571
View directory record Official record
Conditions
Unspecified Atrophy of Edentulous Alveolar Ridge
Interventions
Immediate implant placement with simultaneous bone grafting
Procedure
Lead sponsor
Lithuanian University of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ridge Preservation Following Tooth Extraction Using Porcine and Bovine Xenograft Materials

NCT02802319
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Porcine Xenograft (Zcore), Bovine Xenograft (Bio-Oss)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Wound Healing Following Tooth Extraction and Ridge Preservation Using DFDBA Alone in Particulate Fiber Form and in Combination With Xenograft

NCT05400213
View directory record Official record
Conditions
Dental Extraction, Wound Heal
Interventions
Vallos (DCP), Vallomix (DCF), Vallos-F (DPX), Vallomix-F (DFX)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®

NCT03659617
View directory record Official record
Conditions
Tooth Loss
Interventions
xenograft (BioOss Collagen)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 95 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction

NCT02356965
View directory record Official record
Conditions
Pain
Interventions
Ketamine, Placebo (for Ketamine)
Drug
Lead sponsor
iX Biopharma Ltd.
Other
Eligibility
18 Years to 38 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 2 Interventional

Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect

NCT00121563
View directory record Official record
Conditions
Pain
Interventions
Thalidomide, Ibuprofen or Diazepam
Drug
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
Male only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 23, 2026, 9:09 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB

NCT06038695
View directory record Official record
Conditions
Tooth Extraction, Immediate Implant Placement
Interventions
Xenogeneic Volume-Stable Collagen (VCMX) graft with growth factor-BB
Device
Lead sponsor
I-Ching Wang
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 2 Interventional

Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction

NCT00050362
View directory record Official record
Conditions
Pain, Tooth Extraction
Interventions
Rofecoxib and Bupivacaine
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 23, 2026, 9:09 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

MicroRNA and MicroRNA Inhibitors Socket Study, Pilot Clinical Trial

NCT02579187
View directory record Official record
Conditions
Tooth Extraction Status Nos
Interventions
tooth extraction, CBCT scan, Anesthesia, clinical measurements, Biodegradable sponge (type I bovine collagen), 10µg of pSil-miR200c, cross mattress suture, 10µg of PMIS miR200a plasmids, 5µg of pSil-miR200c and 5µg of PMIS miR200a, Blood, Photos/videos, Wound fluid, saliva, periapical xray, PVS impression
Procedure · Radiation · Drug + 1 more
Lead sponsor
Gustavo Avila-Ortiz DDS, MS, PhD
Other
Eligibility
25 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children

NCT06300073
View directory record Official record
Conditions
Dental Plaque
Interventions
Experimental: U-shaped Power Toothbrush, Placebo Comparator: Soft Manual Toothbrush
Device
Lead sponsor
Lander Enterprises, LLC
Industry
Eligibility
5 Years to 8 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 23, 2026, 9:09 AM EDT
Completed No phase listed Observational

A Clinical and Imaging Study to Evaluate a Novel Dentifrice

NCT02271815
View directory record Official record
Conditions
Gingivitis, Periodontitis, Dental Plaque
Interventions
Oral Hygiene
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Oct 23, 2026, 9:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Wound Healing Following Tooth Extraction and Ridge Preservation Using OsteoGen®

NCT07154693
View directory record Official record
Conditions
Tooth Extraction
Interventions
Combination 70% FDBA and 30% DFDBA, OsteoGen Plug
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 3 Interventional

Analgesic Effects of Cannabidiol for Simple Tooth Extractions in Dental Patients

NCT04271917
View directory record Official record
Conditions
Pain, Acute
Interventions
cannabidiol, placebo, acetaminophen 500mg and ibuprofen 200mg combo
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 2, 2022 · Synced Oct 23, 2026, 9:09 AM EDT
Recruiting Not applicable Interventional

Comparison of Two Types of Bone Grafts in Patients Who Need One of Their Front Teeth Removed and Replaced With an Implant

NCT06722482
View directory record Official record
Conditions
Ridge Preservation, Allografts, Extraction, Tooth, Xenograft
Interventions
FDBA, CEBX
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluation and Comparison of a Novel Dentrifice Formulation on Plaque Removal

NCT06082869
View directory record Official record
Conditions
Dental Plaque
Interventions
Protegera™ toothpaste (NaF), Crest™ Cavity Protection toothpaste (NaF)
Drug
Lead sponsor
Protegera, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bone Augmentation Techniques in Extraction Sockets

NCT01836783
View directory record Official record
Conditions
Tooth Loss
Interventions
Amnion Allograft, Allograft
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Oct 23, 2026, 9:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse

NCT04512482
View directory record Official record
Conditions
Dental Plaque, Dental Caries
Interventions
Bromelain, Powdered sugar
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
10 Years to 25 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 23, 2026, 9:09 AM EDT