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ClinicalTrials.gov public records Last synced Oct 21, 2026, 8:23 AM EDT

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Showing 337–360 of 394 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extremity Injury Clear all
Completed Not applicable Interventional

Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury

NCT05601661
View directory record Official record
Conditions
Cervical Spinal Cord Injury
Interventions
Active VNS, Sham VNS, Arm rehabilitation
Device · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 21, 2026, 8:23 AM EDT
Recruiting No phase listed Observational

A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury

NCT06705855
View directory record Official record
Conditions
NIRS, Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, AKI - Acute Kidney Injury
Interventions
NIRS sensor placement
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Oct 21, 2026, 8:23 AM EDT
Not listed Not applicable Interventional

Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury

NCT05457205
View directory record Official record
Conditions
Spinal Cord Injuries, Spasticity, Muscle
Interventions
Electrical neuromodulation
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Apr 12, 2024 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Not applicable Interventional

Erector Spinae Plane Versus Interscalene Blocks for Shoulder Surgery

NCT03807505
View directory record Official record
Conditions
Anesthesia, Local, Phrenic Nerve Paralysis, Upper Extremity Injury, Shoulder Injury
Interventions
Interscalene brachial plexus nerve block, Erector spinae plane block
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Technology Development for Physical Rehabilitation of Patients With Upper Extremity Motor Deficits (RePlay)

NCT03621969
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Physical exam and medical history, Assessments, Patient Instruction and use of Device (RePlay)
Other · Diagnostic Test · Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Addison, Texas • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2023 · Synced Oct 21, 2026, 8:23 AM EDT
Not listed Not applicable Interventional

Celecoxib for Primary Prophylaxis of Combat-Related Heterotopic Ossification

NCT01631669
View directory record Official record
Conditions
Ossification, Heterotopic
Interventions
Celecoxib
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 3, 2012 · Synced Oct 21, 2026, 8:23 AM EDT
Active, not recruiting Not applicable Interventional

Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis

NCT02089880
View directory record Official record
Conditions
Spinal Cord Injuries, Poliomyelitis, Post-polio Syndrome, Arthritis, Lower Motor Neurone Lesion
Interventions
C-brace, Stance control orthosis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Not applicable Interventional Results available

Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury

NCT00833105
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia, Paresis, Plegia
Interventions
AMES treatment
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Atlanta, Georgia • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Not applicable Interventional

Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability

NCT00601471
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 24, 2010 · Synced Oct 21, 2026, 8:23 AM EDT
Terminated Not applicable Interventional

Does Wearing Tetra-Grip Improve Arm Function in Children Diagnosed With Neonatal Brachial Plexus Palsy?

NCT03647761
View directory record Official record
Conditions
Neonatal Brachial Plexus Palsy
Interventions
Tetra-grip
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
3 Years to 7 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 21, 2026, 8:23 AM EDT
Completed No phase listed Observational

Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol

NCT01606501
View directory record Official record
Conditions
Severe Distal Tibia Injury, Severe Ankle Injury, Severe Foot Injury, Major Soft Tissue Loss, Major Bone Articular Surface Loss, Major Ankle Articular Surface Loss
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
664 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
33
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Oct 21, 2026, 8:23 AM EDT
Active, not recruiting Not applicable Interventional

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population

NCT04784429
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Interventions
Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK)
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
65 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
90
States / cities
Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2024 · Synced Oct 21, 2026, 8:23 AM EDT
Recruiting Not applicable Interventional

The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI

NCT06349434
View directory record Official record
Conditions
SCI - Spinal Cord Injury, Upper Extremity Dysfunction, Upper Extremity Problem
Interventions
MyoMo, conventional therapy
Device · Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Movement Enhancing Device for Children

NCT01959581
View directory record Official record
Conditions
Upper Extremity Dysfunction
Interventions
Movement Enhancing Device
Device
Lead sponsor
University of Delaware
Other
Eligibility
1 Month to 6 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
3
States / cities
Newark, Delaware • Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 6, 2017 · Synced Oct 21, 2026, 8:23 AM EDT
Not listed Not applicable Interventional

Comparing a Synergistic Antimicrobial Cleanser and Gel to Normal Saline and an Amorphous Gel in Reducing Bioburden and Promoting Healing in Chronic Lower Extremity Ulcers

NCT05107050
View directory record Official record
Conditions
Wound of Skin
Interventions
Normal Saline and Amorphous gel, BIAKOS™ Antimicrobial Skin & Wound Cleanser, BIAKŌS Antimicrobial Wound Gel
Device
Lead sponsor
SerenaGroup, Inc.
Network
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Oct 21, 2026, 8:23 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Spinal Cord Injury Leg Rehabilitation

NCT01498991
View directory record Official record
Conditions
Spinal Cord Injury, Paraplegia, Quadriplegia, Tetraplegia
Interventions
AMES Treatment
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Atlanta, Georgia • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 24, 2019 · Synced Oct 21, 2026, 8:23 AM EDT
Recruiting Phase 3 Interventional

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

NCT05699174
View directory record Official record
Conditions
Infections, Infected Wound, Nonunion of Fracture, Injury Leg, Amputation, Internal Fixation; Complications, Infection or Inflammation, Fracture, Lower Extremity Fracture, Antibiotic Side Effect
Interventions
Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
13
States / cities
Indianapolis, Indiana • Baltimore, Maryland • Minneapolis, Minnesota + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 21, 2026, 8:23 AM EDT
Completed No phase listed Observational

Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma

NCT02718768
View directory record Official record
Conditions
Peripheral Nerve Injury(Ies)
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 65 Years
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
17
States / cities
Denver, Colorado • Miami, Florida • Bloomington, Indiana + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Oct 21, 2026, 8:23 AM EDT
Recruiting Not applicable Interventional

Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

NCT06433648
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation of Knee, Amputation; Traumatic, Limb
Interventions
Ottobock CLeg4 + Ottobock foot, SRALAB Hybrid Knee + Polycentric Ankle, SRALAB Hybrid Knee + Passive Ankle, Ottobock CLeg 4 + Polycentric Ankle
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 21, 2026, 8:23 AM EDT
Recruiting No phase listed Observational

Myriad™ Augmented Soft Tissue Reconstruction Registry

NCT05243966
View directory record Official record
Conditions
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury
Interventions
Myriad Matrix™ and Myriad Morcells™
Device
Lead sponsor
Aroa Biosurgery Limited
Industry
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
15
States / cities
Phoenix, Arizona • Los Angeles, California • Fort Myers, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity

NCT03821402
View directory record Official record
Conditions
Upper Limb Spasticity
Interventions
DAXI for injection 250 U, DAXI for injection 375 U, DAXI for injection 500 U, Placebo
Biological · Other
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
26
States / cities
Downey, California • Fountain Valley, California • Long Beach, California + 22 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 21, 2026, 8:23 AM EDT
Enrolling by invitation Early Phase 1 Interventional

Evaluation of In-Vitro Cryo Therapeutic Protocols on Human Cell Samples (TWH-CRYO-001)

NCT07321028
View directory record Official record
Conditions
Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress, Cold-Induced Cellular Injury, Thermal Injury Response, Post-Thaw Viability Impairment, Osmotic Stress Injury, Biomechanical Injury Modeling (In-Vitro), Blunt Force Injuries to the Extremities (Cellular Injury Model), Tissue Damage and Recovery Pathways, Hypothermic Tissue Stress, Cellular Regeneration and Repair
Interventions
Standard Laboratory Cryopreservation Procedure, Enhanced Laboratory Cryopreservation Procedure, Normothermic Cell Culture Control
Other
Lead sponsor
Truway Health, Inc.
Industry
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2066
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Oct 21, 2026, 8:23 AM EDT
Withdrawn Not applicable Interventional

Teletherapy for Upper Extremity Fracture Rehabilitation (TELE-REHAB Study)

NCT04691739
View directory record Official record
Conditions
Upper Limb Surgery, Occupational Therapy
Interventions
occupational therapy
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 21, 2026, 8:23 AM EDT
Completed Not applicable Interventional

Targeted Noninvasive Brain Stimulation (T-NIBS) to Improve Hand Motor Functions in Acquired Brain Injury

NCT04057105
View directory record Official record
Conditions
Upper Extremity Dysfunction, Traumatic Brain Injury
Interventions
Active High-definition Transcranial Direct Current Stimulation (HD-tDCS), MusicGlove
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 21, 2026, 8:23 AM EDT