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ClinicalTrials.gov public records Last synced Oct 26, 2026, 1:30 PM EDT

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Showing 1–24 of 64 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Feeling Anxious Clear all
Withdrawn Phase 4 Interventional

The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives

NCT02028026
View directory record Official record
Conditions
Major Depressive Disorder, Anxiety, Comorbidity
Interventions
Vilazodone, Citalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional

Reducing Isolation and Feeling of Loneliness During Critical Illness

NCT05537311
View directory record Official record
Conditions
Critical Illness, Social Isolation, Anxiety, Depression, Post Intensive Care Unit Syndrome
Interventions
Social Engagement
Behavioral
Lead sponsor
Kirby Mayer
Other
Eligibility
18 Years to 99 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Oct 26, 2026, 1:30 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pregnancy and Anxious Thoughts: The Role of the Immune and Endocrine Systems

NCT03664128
View directory record Official record
Conditions
Perinatal Anxiety
Interventions
Coping with Anxiety through Living Mindfully (CALM) Pregnancy
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Oct 26, 2026, 1:30 PM EDT
Recruiting Not applicable Interventional

Group Exposure Workshops for Socially Anxious Undergraduates

NCT06673407
View directory record Official record
Conditions
Social Anxiety Disorder, Public Speaking Fear, Public Speaking Anxiety, Social Fear
Interventions
Group Exposure for Social Anxiety, Self-Compassion Enhanced Group Exposure Therapy for Social Anxiety, Peer-Enhanced Group Exposure Therapy for Social Anxiety, Peer and Self-Compassion Enhanced Group Exposure Therapy for Social Anxiety
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 30 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 4 Interventional Results available

Brain Imaging of Quetiapine Response in Anxious Depression

NCT00982345
View directory record Official record
Conditions
Major Depression
Interventions
quetiapine (Seroquel XR)
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 30, 2016 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Respiratory Dysregulation and Breathing Training in Anxious Outpatients

NCT00108277
View directory record Official record
Conditions
Anxiety
Interventions
Breathing Training-Raise CO2, Breathing Training- Lower CO2
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2015 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Radicle Calm RDH: A Study Assessing the Impact of Health and Wellness Products on Feelings of Anxiety and Related Health Outcomes

NCT07219628
View directory record Official record
Conditions
Anxiety
Interventions
Calm Product Placebo Control, Calm Active Product 1
Dietary Supplement
Lead sponsor
Radicle Science
Industry
Eligibility
21 Years to 105 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Del Mar, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 26, 2026, 1:30 PM EDT
Enrolling by invitation Phase 2 Interventional

An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)

NCT07161700
View directory record Official record
Conditions
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
Interventions
SPT-300
Drug
Lead sponsor
Seaport Therapeutics
Industry
Eligibility
18 Years to 66 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
20
States / cities
Chino, California • Garden Grove, California • Glendale, California + 17 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Volunteer-based Lunch Program on Feelings of Loneliness in Elders

NCT03552328
View directory record Official record
Conditions
Aged, Loneliness, Depression, Anxiety
Interventions
Lunch with Medical Student, Control
Other
Lead sponsor
University of South Florida
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 1 Interventional

Smoking Cessation for Depression and Anxiety Treatment

NCT02002858
View directory record Official record
Conditions
Smoking, Anxiety Disorders, Depression Disorders
Interventions
Nicotine Patch, Depression and Anxiety Smoking Cessation Treatment, Educational-Support Psychotherapy
Drug · Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2017 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Test of an Inhibitory Learning Model of Extinction in Treatment of Anxious Youth

NCT03372915
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Standard Exposure, Exposure + Inhibitory Learning
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
7 Years to 17 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Empowering Anxious Parents to Manage Child Avoidance Behaviors

NCT04453865
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Project EMPOWER, Online Resources and Referrals
Behavioral · Other
Lead sponsor
Stony Brook University
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Oct 26, 2026, 1:30 PM EDT
Active, not recruiting Phase 3 Interventional Accepts healthy volunteers

Partners in Caring for Anxious Youth

NCT04598230
View directory record Official record
Conditions
Anxiety, Separation, Anxiety, Generalized, Anxiety, Social
Interventions
Cognitive Behavioral Therapy (CBT), Combination therapy (COMB)
Behavioral · Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
7 Years to 17 Years
Enrollment
468 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
3
States / cities
Los Angeles, California • Chicago, Illinois • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional

Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy

NCT03430765
View directory record Official record
Conditions
Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Katherine Hadlandsmyth
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 2 Interventional Results available

Effect of LY686017 on Alcohol Craving

NCT00310427
View directory record Official record
Conditions
Alcohol Dependence, Alcoholism
Interventions
LY686017, Placebo
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 20, 2010 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional

Frontal Stimulation to Modulate Threat Sensitivity in Anxious Depression

NCT04948944
View directory record Official record
Conditions
Depression, Anxiety and Fear
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 14, 2023 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 2 Interventional Results available

PH94B in the Treatment of Adjustment Disorder With Anxiety

NCT04404192
View directory record Official record
Conditions
Adjustment Disorder With Anxious Mood
Interventions
PH94B, Placebo
Drug
Lead sponsor
VistaGen Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Watertown, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional

Augmenting Exposure Therapy With Self-Distancing

NCT03549455
View directory record Official record
Conditions
Anxiety
Interventions
Exposure Therapy and Self Distancing
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
7 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy (ACT) for Anxious Cancer Survivors

NCT02550925
View directory record Official record
Conditions
Cancer
Interventions
Acceptance and Commitment Therapy (ACT) Group, Usual Care
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
21 Years to 95 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 26, 2020 · Synced Oct 26, 2026, 1:30 PM EDT
Not listed Phase 4 Interventional

Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)

NCT04245748
View directory record Official record
Conditions
Anxious Depression, Depression
Interventions
Escitalopram, Duloxetine
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 50 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Oct 26, 2026, 1:30 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Heartfulness Meditation on Brain Waves and How Calm One Feels During Meditation

NCT04721379
View directory record Official record
Conditions
Anxiety, Stress
Interventions
Meditation
Behavioral
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dover, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Ketamine for Depression: An MRI Study

NCT02544607
View directory record Official record
Conditions
Depression, Anxious Depression, Major Depressive Disorder
Interventions
Ketamine, Magnetic Resonance Imaging (MRI)
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 2 Interventional Results available

An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress

NCT02498392
View directory record Official record
Conditions
Depressive Disorder, Anxiety
Interventions
JNJ-42165279, Placebo
Drug · Other
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 64 Years
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
8
States / cities
Costa Mesa, California • Oceanside, California • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 26, 2026, 1:30 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Baclofen for Treating Anxiety and Alcoholism

NCT01751386
View directory record Official record
Conditions
Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems, Alcohol Drinking, Anxiety Disorder
Interventions
Baclofen, Placebo
Drug · Other
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Oct 26, 2026, 1:30 PM EDT