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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Fetal Aneuploidy Clear all
Completed No phase listed Observational

Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies

NCT01555346
View directory record Official record
Conditions
Down Syndrome, Fetal Aneuploidy
Interventions
Not listed
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
18 Years to 60 Years · Female only
Enrollment
3,062 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
27
States / cities
Mobile, Alabama • Tucson, Arizona • Campbell, California + 24 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

MatErnal BLood IS Source to Accurately Diagnose Fetal Aneuploidy

NCT01122524
View directory record Official record
Conditions
Pregnant Women, Prenatal Care
Interventions
Not listed
Lead sponsor
Verinata Health, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
11
States / cities
Los Angeles, California • San Francisco, California • Fort Collins, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2011 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

Development of a Prenatal Test for Fetal Aneuploidy Detection

NCT01451671
View directory record Official record
Conditions
Fetal Complications
Interventions
Not listed
Lead sponsor
Cindy Cisneros
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
3
States / cities
San Diego, California • Louisville, Kentucky • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 29, 2020 · Synced Jul 22, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of a Novel Computerized Decision Aid for Prenatal Aneuploidy Screening

NCT02991729
View directory record Official record
Conditions
Aneuploidy, Pregnancy Complications
Interventions
iPad-based decision aid, Genetic counseling appointment
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Jul 22, 2026, 6:07 PM EDT
Terminated No phase listed Observational

Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies

NCT02226315
View directory record Official record
Conditions
Down Syndrome, Edwards Syndrome, Patau Syndrome, Turner Syndrome
Interventions
Not listed
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 16, 2015 · Synced Jul 22, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Single Embryo TrAnsfeR of Euploid Embryo

NCT02268786
View directory record Official record
Conditions
Infertility, Aneuploidy
Interventions
Preimplantation Genetic Screening by NGS
Other
Lead sponsor
Illumina, Inc.
Industry
Eligibility
25 Years to 40 Years · Female only
Enrollment
661 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
28
States / cities
Tempe, Arizona • Encino, California • Laguna Niguel, California + 24 more
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker

NCT00770458
View directory record Official record
Conditions
Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Turner Syndrome
Interventions
Not listed
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
7
States / cities
La Jolla, California • San Diego, California • San Jose, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2010 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

Non-Invasive Screening for Fetal Aneuploidy

NCT00847990
View directory record Official record
Conditions
Down Syndrome, Edwards Syndrome
Interventions
Maternal blood screening test for fetal aneuploidy
Other
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
25
States / cities
Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2011 · Synced Jul 22, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

GEM: Impact of a Video Education Tool on Decisional Conflict Among Prenatal Patients

NCT06771453
View directory record Official record
Conditions
Aneuploidy, Genetic Counseling, Informed Consent, Decisional Conflict
Interventions
Video Educational Tool Regarding Prenatal Genetics
Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Non-Invasive Chromosomal Evaluation of Trisomy Study

NCT02201862
View directory record Official record
Conditions
Aneuploidy, Trisomy 21, Trisomy 18, Trisomy 13, Down Syndrome
Interventions
Not listed
Lead sponsor
Cindy Cisneros
Industry
Eligibility
18 Years to 60 Years · Female only
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
3
States / cities
San Diego, California • Oaks, Pennsylvania • Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 29, 2020 · Synced Jul 22, 2026, 6:07 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Prenatal Computer-Aided Genetics Education Module

NCT03449225
View directory record Official record
Conditions
Autosomal Recessive Disorder, Aneuploidy
Interventions
Computer-Aided Genetic Education Module
Other
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies

NCT01052688
View directory record Official record
Conditions
Down Syndrome, Aneuploidy
Interventions
Maternal blood draw of 30 to 50ml
Other
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2021
U.S. locations
10
States / cities
Phoenix, Arizona • San Diego, California • Washington D.C., District of Columbia + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2021 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

A New Prenatal Blood Test for Down Syndrome

NCT00877292
View directory record Official record
Conditions
Down Syndrome, Trisomy 21
Interventions
Not listed
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older · Female only
Enrollment
4,664 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
12
States / cities
Birmingham, Alabama • Los Angeles, California • New Haven, Connecticut + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Jul 22, 2026, 6:07 PM EDT
Not yet recruiting Not applicable Interventional

Prenatal Genetics Chatbot Trial: Prenatal GENEie

NCT07077707
View directory record Official record
Conditions
Genetic Counseling
Interventions
Prenatal GENEie Chatbot, In-person genetic counseling
Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
1,470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jul 22, 2026, 6:07 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial

NCT01545674
View directory record Official record
Conditions
Trisomy 13, Trisomy 18, Trisomy 21, Aneuploidy
Interventions
Blood Draw
Procedure
Lead sponsor
Natera, Inc.
Industry
Eligibility
Female only
Enrollment
937 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2023
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 16 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

National Prevalence and Impact of Noninvasive Prenatal Testing

NCT02284399
View directory record Official record
Conditions
Aneuploidy
Interventions
non-invasive prenatal testing
Other
Lead sponsor
Obstetrix Medical Group
Industry
Eligibility
18 Years to 60 Years · Female only
Enrollment
4,488 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
7
States / cities
Phoenix, Arizona • Long Beach, California • San Jose, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Non-invasive Prenatal Diagnostic Validation Study

NCT01574781
View directory record Official record
Conditions
Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy, Sex Chromosome Aberrations, Other Microdeletions
Interventions
Blood draw, Cheek swab/Saliva Sampling
Procedure
Lead sponsor
Natera, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,781 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2013 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Prenatal Test for Fetal Aneuploidy Detection

NCT01256606
View directory record Official record
Conditions
Aneuploidy, Trisomy 21
Interventions
Not listed
Lead sponsor
Roche Sequencing Solutions
Industry
Eligibility
18 Years to 60 Years · Female only
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
6
States / cities
Oakland, California • Sacramento, California • San Diego, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Jul 22, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Videos to Improve Patient Knowledge on Prenatal Genetics

NCT03816423
View directory record Official record
Conditions
Aneuploidy, Birth Defect
Interventions
video
Other
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older · Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Jul 22, 2026, 6:07 PM EDT
Not listed No phase listed Observational

Non-Invasive Screening for Fetal Aneuploidy

NCT02317965
View directory record Official record
Conditions
Down Syndrome, Edwards Syndrome
Interventions
Maternal Blood Draw
Other
Lead sponsor
Progenity, Inc.
Industry
Eligibility
18 Years to 54 Years · Female only
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
10
States / cities
Campbell, California • Long Beach, California • Denver, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Jul 22, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Video Education on Patients' Knowledge and Attitudes of Privacy in Prenatal Genetics

NCT04420858
View directory record Official record
Conditions
Aneuploidy, Genetic Disease, Pregnancy Related
Interventions
Enhanced (experimental) education, Standard (control) education.
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older · Female only
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Jul 22, 2026, 6:07 PM EDT
Recruiting No phase listed Observational

The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment

NCT07643896
View directory record Official record
Conditions
Pregnant Individuals, Aneuploidy, Down Syndrome (Trisomy 21), 22q11.2 Deletion Syndrome, Trisomy 13, Trisomy 18, Sex Chromosome Abnormalities
Interventions
Not listed
Lead sponsor
BillionToOne Inc.
Industry
Eligibility
Female only
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
6
States / cities
Phoenix, Arizona • West Covina, California • Sarasota, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

SNP-based Microdeletion and Aneuploidy RegisTry (SMART)

NCT02381457
View directory record Official record
Conditions
22q11 Deletion Syndrome, DiGeorge Syndrome, Trisomy 21, Trisomy 18, Trisomy 13, Monosomy X, Sex Chromosome Abnormalities, Cri-du-Chat Syndrome, Angelman Syndrome, Prader-Willi Syndrome, 1p36 Deletion Syndrome
Interventions
Not listed
Lead sponsor
Natera, Inc.
Industry
Eligibility
18 Years to 48 Years · Female only
Enrollment
20,960 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
16
States / cities
San Francisco, California • Camden, New Jersey • Mount Laurel, New Jersey + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Jul 22, 2026, 6:07 PM EDT
Completed No phase listed Observational

Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies

NCT01597063
View directory record Official record
Conditions
Aneuploidy, Down Syndrome, Noninvasive Prenatal Screening
Interventions
SEQureDx Trisomy Test
Device
Lead sponsor
Sequenom, Inc.
Industry
Eligibility
18 Years to 34 Years · Female only
Enrollment
3,333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
27
States / cities
Mobile, Alabama • Chandler, Arizona • Phoenix, Arizona + 22 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Jul 22, 2026, 6:07 PM EDT