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Showing 1–24 of 48 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Fractional Flow Reserve Clear all
Completed Phase 1 Interventional Results available

Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia

NCT01161121
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
adenosine, regadenoson
Drug
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Jacksonville, Florida • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

TRanslesIonal Assessment of Gradients During Endovascular Therapy

NCT03163199
View directory record Official record
Conditions
Peripheral Arterial Disease, Fractional Flow Reserve, Hemodynamics
Interventions
Translesional Hemodynamic Measurement
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

Inclusive Invasive Physiological Assessment in Angina Syndromes Registry

NCT04485234
View directory record Official record
Conditions
Coronary Artery Disease, Microvascular Coronary Artery Disease
Interventions
Resting distal coronary to aortic pressure ratio, Fractional flow reserve, Coronary Flow Reserve, Microvascular resistance
Diagnostic Test
Lead sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Other
Eligibility
18 Years and older
Enrollment
2,322 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Jun 26, 2026, 7:27 PM EDT
Not listed Phase 3 Interventional

Heartflow (AFFECTS)

NCT02973126
View directory record Official record
Conditions
Cardiovascular Abnormalities
Interventions
FFRct and SPECT
Procedure
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery

NCT04221594
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Invasive Cardiac Catheterization (ICA), Coronary Computed Tomographic Angiogram (CCTA), Dynamic Cardiac Positron Emission Tomography (dPET)
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
3
States / cities
Atlanta, Georgia • Roslyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Jun 26, 2026, 7:27 PM EDT
Completed Not applicable Interventional

Multi-modality Imaging in Acute Myocardial Infarction

NCT02926755
View directory record Official record
Conditions
Acute Myocardial Infarction, STEMI, Coronary Artery Disease, Atherosclerotic Plaque Disruption With Thrombosis of Artery
Interventions
Coronary Angiography
Procedure
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jun 26, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

Ranolazine Among Unrevascularized Chronic Stable Angina Patients

NCT02265796
View directory record Official record
Conditions
Angina
Interventions
Ranolazine, Sugar pill
Drug
Lead sponsor
North Florida Foundation for Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

Fast Assessment of STenosis Severity- FASTII Study

NCT03791320
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Vessel Fractional Flow Reserve
Diagnostic Test
Lead sponsor
Erasmus Medical Center
Other
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 23, 2020 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational Results available

Validation of a Computed Tomography (CT) Based Fractional Flow Reserve (FFR) Software Using the 320 Detector Aquilion ONE CT Scanner.

NCT03149042
View directory record Official record
Conditions
Atherosclerosis, Coronary
Interventions
CCTA
Diagnostic Test
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Jun 26, 2026, 7:27 PM EDT
Terminated Not applicable Interventional Results available

The Computed Tomography-derived Fractional Flow Reserve STAT Trial

NCT03263806
View directory record Official record
Conditions
Heart Disease, Coronary, Chest Pain, Acute Coronary Syndrome
Interventions
CTFFR-Guided Group Management, SOC Group Management
Diagnostic Test
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 2, 2018 · Synced Jun 26, 2026, 7:27 PM EDT
Terminated Phase 2 Interventional Results available

Effectiveness of Ranolazine on Reducing Chest Pain in Patients With Blockage But no Stents

NCT02147834
View directory record Official record
Conditions
Angina
Interventions
Ranolazine, Sugar pill
Drug
Lead sponsor
North Florida Foundation for Research and Education
Other
Eligibility
18 Years to 99 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Jun 26, 2026, 7:27 PM EDT
Not listed No phase listed Observational

ELUCIDATE FFRct Study

NCT06018194
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
ElucidVivo
Device
Lead sponsor
Elucid Bioimaging Inc.
Industry
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
9
States / cities
Beverly Hills, California • Atlanta, Georgia • Fort Wayne, Indiana + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)

NCT02184117
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Adenosine, Contrast Media, Resting conditions
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
763 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Palo Alto, California • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 15, 2016 · Synced Jun 26, 2026, 7:27 PM EDT
Not listed No phase listed Observational

Evaluation of the Opsens Fractional Flow Reserve (FFR) Wire as a "Work Horse" Wire

NCT03227588
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Fractional Flow Reserve
Diagnostic Test
Lead sponsor
Central Arkansas Veterans Healthcare System
Federal
Eligibility
18 Years to 89 Years
Enrollment
1,000 participants
Timeline
2017 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

Evaluation of a Novel Non-Invasive Automated Fractional Flow Reserve Software System in Patients With Coronary Artery Disease

NCT06183294
View directory record Official record
Conditions
Stable Angina, Unstable Angina, NSTEMI
Interventions
Collecting invasive FFR measurements.
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Jun 26, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

PrEssure wiRe Compared to Microcatheter-based Sensing Technology For the Evaluation of FFR Measurements

NCT02648230
View directory record Official record
Conditions
Ischemia, Angina
Interventions
St. Jude Medical Pressure Wire, ACIST Navvus Microcatheter
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Jun 26, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Side Branch FFR After Provisional Stenting

NCT03115580
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Rotational atherectomy, Cutting Balloon Angioplasty
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 13, 2020 · Synced Jun 26, 2026, 7:27 PM EDT
Completed Not applicable Interventional Results available

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)

NCT00267774
View directory record Official record
Conditions
Coronary Arteriosclerosis
Interventions
Fractional flow reserve, Angio-guided PCI
Device · Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1,005 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2017 · Synced Jun 26, 2026, 7:27 PM EDT
Terminated No phase listed Observational

The Evaluation of the Roles of New Cardiac Imaging in Patients With Chest Pain

NCT03800862
View directory record Official record
Conditions
Cardiology, Radiology, Stenoses
Interventions
CT-FFR and CTP
Device
Lead sponsor
Lancaster General Hospital
Other
Eligibility
45 Years to 85 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 26, 2022 · Synced Jun 26, 2026, 7:27 PM EDT
Terminated Not applicable Interventional Results available

A Prospective Study of Fractional Flow Reserve Assessment of Intermediate Coronary Stenoses in Severe Aortic Stenosis

NCT03442400
View directory record Official record
Conditions
Coronary Artery Stenoses, Aortic Stenosis
Interventions
Volcano iFR/FFR Verrata Plus coronary pressure/flow wire
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
20 Years to 110 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 4, 2023 · Synced Jun 26, 2026, 7:27 PM EDT
Terminated No phase listed Observational

Functional Assessment of Coronary Artery Disease by CTA Flow Encoding

NCT02286401
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
40 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2017 · Synced Jun 26, 2026, 7:27 PM EDT
Not listed No phase listed Observational

FFR vs. icECG in Coronary Bifurcations

NCT01724957
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Intracoronary ECG
Procedure
Lead sponsor
University National Heart Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Jun 26, 2026, 7:27 PM EDT
Active, not recruiting No phase listed Observational

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended

NCT07308860
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
FFR-guided PCI, CABG
Procedure
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jun 26, 2026, 7:27 PM EDT
Completed No phase listed Observational

Fractional Flow Reserve (FFR) Versus Instant Wave-Free Ratio (iFR)

NCT01559493
View directory record Official record
Conditions
Coronary Artery Disease, Plaque, Atherosclerotic
Interventions
Not listed
Lead sponsor
NHS National Waiting Times Centre Board
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2012 · Synced Jun 26, 2026, 7:27 PM EDT