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ClinicalTrials.gov public records Last synced Nov 6, 2026, 4:11 PM EST

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Fractional Flow Reserve Clear all

Conditions: Coronary Artery Disease, Acute Coronary Syndrome
Interventions: Fractional Flow Reserve; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 2,217 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 4
States / cities: Huntsville, Alabama • Orlando, Florida • Decatur, Georgia + 1 more

Conditions: Coronary Disease, Coronary Stenosis
Interventions: FFR guided PCI, CABG, Resolute Integrity Stent, Resolute Onyx Stent; Procedure · Device
Lead sponsor: Stanford University; Other
Eligibility: 21 Years and older
Enrollment: 1,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2024
U.S. locations: 13
States / cities: Palo Alto, California • Stanford, California • Decatur, Georgia + 9 more

Conditions: Coronary Artery Stenosis
Interventions: FFR, IVUS, VH, or combination of the three; Procedure
Lead sponsor: Piedmont Healthcare; Other
Eligibility: 21 Years to 85 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Coronary Artery Disease
Interventions: PET-MPI Protocol, CT-MPI, Coronary CT angiography (CCTA) for CT-FFR calculation, Regadenoson; Diagnostic Test · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Coronary Artery Disease
Interventions: FFR; Device
Lead sponsor: HeartFlow, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 285 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Mobile, Alabama

Conditions: Coronary Artery Disease
Interventions: SPECT imaging; Radiation
Lead sponsor: Prem Soman; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Left Anterior Descending Coronary Artery Stenosis
Interventions: OpSens Medical OptoWire, FFR; Device · Procedure
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: New York, New York • Roslyn, New York

Conditions: Coronary Artery Disease, Computed Tomography
Interventions: CT FFR; Diagnostic Test
Lead sponsor: Stanford University; Other
Eligibility: 21 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Stanford, California

Conditions: Coronary Artery Disease
Interventions: Stenting plus OMT, OMT, Standard of care; Other
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 21 Years and older
Enrollment: 1,170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 6
States / cities: Palo Alto, California • Stanford, California • Atlanta, Georgia + 3 more

Conditions: Coronary Artery Disease
Interventions: Not listed
Lead sponsor: Volcano Corporation; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Atherosclerosis, Coronary
Interventions: CCTA; Diagnostic Test
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Coronary Artery Disease
Interventions: FFR-guided PCI, CABG; Procedure
Lead sponsor: Stanford University; Other
Eligibility: 21 Years and older
Enrollment: 1,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Stanford, California

Conditions: Peripheral Artery Disease, Critical Limb Ischemia
Interventions: Orbital Atherectomy System, Balloon Angioplasty; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 8
States / cities: Little Rock, Arkansas • Atlanta, Georgia • Davenport, Iowa + 5 more

Conditions: Coronary Artery Disease
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: 40 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Coronary Artery Disease
Interventions: Vessel Fractional Flow Reserve; Diagnostic Test
Lead sponsor: Erasmus Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 330 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Coronary Artery Stenoses, Aortic Stenosis
Interventions: Volcano iFR/FFR Verrata Plus coronary pressure/flow wire; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 20 Years to 110 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Ischemia, Angina
Interventions: St. Jude Medical Pressure Wire, ACIST Navvus Microcatheter; Device
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Angina
Interventions: Ranolazine, Sugar pill; Drug
Lead sponsor: North Florida Foundation for Research and Education; Other
Eligibility: 18 Years to 99 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Coronary Artery Disease
Interventions: Rotational atherectomy, Cutting Balloon Angioplasty; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Coronary Artery Disease
Interventions: FFR/CFR and IVUS; Device
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 100 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: Cincinnati, Ohio

Conditions: Non-obstructive Coronary Disease, Acute or Chronic Coronary Artery Disease
Interventions: Patients with intermediate coronary artery stenosis with clinically indicated FFR assessment., Microvascular assessment; Procedure
Lead sponsor: AngioInsight; Industry
Eligibility: 18 Years and older
Enrollment: 620 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 10
States / cities: Palo Alto, California • Washington D.C., District of Columbia • Minneapolis, Minnesota + 4 more

Conditions: Cardiology, Radiology, Stenoses
Interventions: CT-FFR and CTP; Device
Lead sponsor: Lancaster General Hospital; Other
Eligibility: 45 Years to 85 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Lancaster, Pennsylvania

Conditions: Coronary Artery Disease
Interventions: adenosine, regadenoson; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: Jacksonville, Florida • St Louis, Missouri

Conditions: Coronary Arteriosclerosis
Interventions: Fractional flow reserve, Angio-guided PCI; Device · Procedure
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 1,005 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2015
U.S. locations: 1
States / cities: Stanford, California

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PRESSUREwire Study

A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease

Validation of Stenosis Assessment by Coronary Artery Computed Tomography Against Invasive Measurements of Fractional Flow Reserve in Patients With Significant Coronary Artery Stenoses

The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI

Determination of Fractional Flow Reserve by Anatomic Computed Tomographic Angiography

Simultaneous Assessment of FFR and SPECT

The Drift-Reduction for Improved FFR Using Fiberoptic Technology (DRIFT) Study

Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates

FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT

Fractional Flow Reserve and Intravascular Ultrasound RelationShip STudy

Validation of a Computed Tomography (CT) Based Fractional Flow Reserve (FFR) Software Using the 320 Detector Aquilion ONE CT Scanner.

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended

Complete Lesion Assessment With ffR and IVUS TechnologY

Functional Assessment of Coronary Artery Disease by CTA Flow Encoding

Fast Assessment of STenosis Severity- FASTII Study

A Prospective Study of Fractional Flow Reserve Assessment of Intermediate Coronary Stenoses in Severe Aortic Stenosis

PrEssure wiRe Compared to Microcatheter-based Sensing Technology For the Evaluation of FFR Measurements

Effectiveness of Ranolazine on Reducing Chest Pain in Patients With Blockage But no Stents

Side Branch FFR After Provisional Stenting

Measurements to Assess Severity of Epicardial Stenoses

Simultaneous Measurement of EpicArdial and Microvascular ResisTance Via Angiographic FLOW Study

The Evaluation of the Roles of New Cardiac Imaging in Patients With Chest Pain

Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)