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ClinicalTrials.gov public records Last synced Oct 23, 2026, 8:34 AM EDT

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Showing 313–336 of 352 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Functional Colonic Disease Clear all
Completed No phase listed Observational

Pediatric Alliance for International Neurogastrointestinal Functional Research

NCT01099787
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
4 Years to 16 Years
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
6
States / cities
Hartford, Connecticut • Chicago, Illinois • New Orleans, Louisiana + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2018 · Synced Oct 23, 2026, 8:34 AM EDT
Not listed Not applicable Interventional

Effects of a Multispecies Probiotic on Migraine

NCT04696458
View directory record Official record
Conditions
Migraine, Irritable Bowel Syndrome, Headache, Migraine
Interventions
Lactobacillus plantarum (CECT7484 and CECT7485)/ Pediococcus acidilactici (CECT7483), Placebo Comparator: Placebo
Dietary Supplement · Other
Lead sponsor
Scripps Health
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2022 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Phase 2 Interventional Results available

Comparison of Rimegepant and Placebo for Pain in IBS

NCT06221111
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Rimegepant 75 MG [Nurtec]
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Not applicable Interventional

Plant Exosomes +/- Curcumin to Abrogate Symptoms of Inflammatory Bowel Disease

NCT04879810
View directory record Official record
Conditions
Irritable Bowel Disease
Interventions
Sigmoidoscopy and biopsy, blood work
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Oct 23, 2026, 8:34 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain

NCT00824941
View directory record Official record
Conditions
Obesity, Stress, Irritable Bowel Syndrome, Women, Abdominal Pain
Interventions
Not listed
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
13 Years to 45 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Oct 23, 2026, 8:34 AM EDT
Not yet recruiting Not applicable Interventional

The Mechanism Underlying the Analgesic Effect of the Music of IBS Pain

NCT06706778
View directory record Official record
Conditions
Abdominal Pain/ Discomfort, Irritable Bowel Syndrome
Interventions
Music intervention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Phase 2 Interventional

Asimadoline for the Treatment of Subjects With Irritable Bowel Syndrome

NCT00454688
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Asimadoline, Placebo
Drug
Lead sponsor
Tioga Pharmaceuticals
Industry
Eligibility
18 Years to 79 Years
Enrollment
596 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
112
States / cities
Huntsville, Alabama • Pheonix, Arizona • Phoenix, Arizona + 96 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2011 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing Uniqueness of Inflammatory Bowel Disease Related Microbiome-derived Biomarkers

NCT05640583
View directory record Official record
Conditions
Irritable Bowel Disease
Interventions
Hygieacare System
Device
Lead sponsor
HyGIeaCare, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Not applicable Interventional

Brain Imaging and Pain in Irritable Bowel Syndrome

NCT00065754
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
placebo
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2011 · Synced Oct 23, 2026, 8:34 AM EDT
Not listed Not applicable Interventional

Improving Bowel Function and Quality of Life After Spinal Cord Injury

NCT03949660
View directory record Official record
Conditions
Neurogenic Bowel
Interventions
Stimulation for blood pressure without stand, Stimulation for blood pressure with stand, Stimulation for trunk and core without stand, Stimulation for trunk or core with stand
Device
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 23, 2026, 8:34 AM EDT
Recruiting Phase 2 Interventional

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

NCT07545772
View directory record Official record
Conditions
Irritable Bowel Syndrome, Constipation
Interventions
LY3537031, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 75 Years
Enrollment
342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
14
States / cities
Mesa, Arizona • Anaheim, California • Lancaster, California + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 23, 2026, 8:34 AM EDT
Completed No phase listed Observational

LOTRONEX® in Severe Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)

NCT01257477
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
Prometheus Laboratories
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
67
States / cities
Tuscaloosa, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 60 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 23, 2026, 8:34 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluating and Treating Potential Research Participants With Digestive Disorders

NCT01736280
View directory record Official record
Conditions
Stress, Irritable Bowel Syndrome, Obesity, Abdominal Pain
Interventions
Standard of Care
Other
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
2 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Not applicable Interventional

Well-being in IBS: Strengths and Happiness (WISH)

NCT05289089
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Positive Psychology Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Not applicable Interventional

Do Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program?

NCT03823742
View directory record Official record
Conditions
Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Functional Gastrointestinal Disorders, Functional Bowel Disorder, Functional Abdominal Pain, Functional Abdominal Pain Disorders
Interventions
Cognitive Behavioral Therapy, Low FODMAP Diet
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
7 Years to 12 Years
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 23, 2026, 8:34 AM EDT
Withdrawn Phase 1 Interventional

Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain

NCT01269671
View directory record Official record
Conditions
Functional Abdominal Pain, Irritable Bowel Syndrome, Functional Dyspepsia
Interventions
Melatonin, Peppermint Oil (mentharil), and Simethicone, Sugar pill
Drug · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
8 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 24, 2015 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients

NCT01056107
View directory record Official record
Conditions
Irritable Bowel Syndrome Constipation Predominant
Interventions
ROSE-010, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 31, 2013 · Synced Oct 23, 2026, 8:34 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Visible Abdominal Distension

NCT06369753
View directory record Official record
Conditions
Irritable Bowel Syndrome, Dyspepsia, Functional Bloating
Interventions
Biofeedback, Placebo
Behavioral
Lead sponsor
Hospital Universitari Vall d'Hebron Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Not applicable Interventional Results available

Self Administered Cognitive Behavior Therapy for Irritable Bowel Syndrome

NCT00738920
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Self Administered Cognitive Behavior Therapy, Therapist Administered Cognitive Behavior Therapy, Behavioral Education and Supportive Therapy
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 70 Years
Enrollment
436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
2
States / cities
Chicago, Illinois • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2022 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Phase 2 Interventional Results available

A Placebo-Controlled Trial of St. John's Wort for Irritable Bowel Syndrome

NCT00587860
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
St. John's wort, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2010 · Synced Oct 23, 2026, 8:34 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Developing Novel Microbiota-Targeted Therapies for Irritable Bowel Syndrome

NCT02249169
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Phase 1 Interventional

A Study to Evaluate Fecal Microbiota Transplantation Engraftment in IBS

NCT02847481
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
fecal microbiota transplantation, placebo fecal microbiota transplantation, FMT with antibiotic pre-treatment (v1), FMT with antibiotic pre-treatment (v2)
Procedure · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Oct 23, 2026, 8:34 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Cheno Effect on Transit in Health and IBS-C

NCT00912301
View directory record Official record
Conditions
Constipation-predominant Irritable Bowel Syndrome
Interventions
Sodium chenodeoxycholate (NaCDC), Placebo
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 2, 2012 · Synced Oct 23, 2026, 8:34 AM EDT
Terminated Phase 2 Interventional Results available

Olorinab in Irritable Bowel Syndrome With Predominant Constipation (IBS-C) and Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)

NCT04043455
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Olorinab, Placebo
Drug
Lead sponsor
Arena Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
69
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 60 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 23, 2026, 8:34 AM EDT