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Showing 1–24 of 451 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gum Disease Clear all
Completed No phase listed Observational

Chitosan Chewing Gum Study in Dialysis Patients

NCT01770470
View directory record Official record
Conditions
End Stage Renal Disease
Interventions
Chitosan
Dietary Supplement
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional

Brief Title: a Clinical Study to Assess Gingivitis

NCT06659471
View directory record Official record
Conditions
Gingival Diseases
Interventions
0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mechanisms and Treatment Response of Aggressive Periodontitis in Children

NCT01330719
View directory record Official record
Conditions
Aggressive Periodontitis
Interventions
Diseased periodontal treatment, Conventional periodontal treatment
Procedure
Lead sponsor
University of Florida
Other
Eligibility
5 Years to 90 Years
Enrollment
514 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2022
U.S. locations
10
States / cities
Brooker, Florida • Fort Lauderdale, Florida • Gainesville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Jun 26, 2026, 2:45 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.

NCT06966492
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Stannous Fluoride Toothpaste (SnF)
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional

Diode Laser Study for Periodontal Maintenance Patients

NCT01215201
View directory record Official record
Conditions
Periodontal Diseases, Periodontitis, Apical, Chronic Nonsuppurative, Suppuration of Gingival Crevice
Interventions
Scaling and Root Planing, Diode Laser + Scaling and Root Planing
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Jun 26, 2026, 2:45 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Case Series Evaluation of a Short Dental Implant

NCT00798031
View directory record Official record
Conditions
Tooth Loss
Interventions
A minimum of two but up to three Astra Tech Dental Implant, Fixture Osseospeed will be placed in the posterior upper jaw of 20 eligible subjects., Placement of dental implant, dental implant
Device
Lead sponsor
Clark Stanford
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Jun 26, 2026, 2:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measurement of Bite Force in Humans

NCT00223327
View directory record Official record
Conditions
Dental Pulp Necrosis, Periapical Periodontitis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 60 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Phase 1 Interventional Results available

Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)

NCT04210375
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
JK07, Matching Placebo
Drug
Lead sponsor
Salubris Biotherapeutics Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
7
States / cities
Tucson, Arizona • Stanford, California • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Jun 26, 2026, 2:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis

NCT01156155
View directory record Official record
Conditions
Rheumatoid Arthritis, Osteoarthritis, Periodontal Disease
Interventions
Digital xray of jaw and teeth, Blood draw, questionnaires, Periodontal Examination, Bilateral digital xray of hands
Radiation · Procedure · Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
617 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2018
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Jun 26, 2026, 2:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study

NCT01878071
View directory record Official record
Conditions
Obesity, Peri-implant Inflammation, Peri-implantitis
Interventions
Not listed
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of OSSIX-Plus Resorbable Collagen Membranes for Alveolar Ridge Preservation Following Exodontia

NCT00639860
View directory record Official record
Conditions
Alveolar Bone Loss, Loss of Teeth Due to Extraction, Edentulous Alveolar Ridge
Interventions
OSSIX-Plus
Device
Lead sponsor
William Giannobile
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 30, 2016 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Clinical Outcomes Between GentleWave® and Biolase®

NCT05555043
View directory record Official record
Conditions
Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
Interventions
Irrisafe ip, GentleWave System, Waterlase iPlus
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
14 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional Results available

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

NCT00790569
View directory record Official record
Conditions
Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions
nicotine, varenicline, placebo
Drug · Other
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 120 Years
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jun 26, 2026, 2:45 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Intaglio Surface of Full-arch Implant Supported Prosthesis

NCT06636097
View directory record Official record
Conditions
Peri-Implantitis
Interventions
Full arch
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Treatment of Post-Extraction Dehisced Socket - A Case Series Study

NCT02980211
View directory record Official record
Conditions
Tooth Loss
Interventions
Alveolar Ridge Reconstruction
Drug
Lead sponsor
Gustavo Avila-Ortiz DDS, MS, PhD
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Effects of DHA on Periodontitis

NCT01976806
View directory record Official record
Conditions
Periodontitis, Gingivitis, Inflammation
Interventions
Aspirin, Docosahexaenoic acid, Placebo (for Docosahexaenoic acid)
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
40 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional Results available

Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis

NCT02883244
View directory record Official record
Conditions
Gingivitis
Interventions
Soft-Picks Advanced, Floss
Device
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Jun 26, 2026, 2:45 AM EDT
Terminated Not applicable Interventional

Dental Carotid Cognitive Study

NCT03755362
View directory record Official record
Conditions
Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
Interventions
Standard Treatment, Intensive Treatment
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years to 100 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Jun 26, 2026, 2:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Gingival Augmentation and Root Coverage With Superficial and Deep Cut Acellular Dermal Matrices

NCT05956496
View directory record Official record
Conditions
Gingival Recession
Interventions
Allograft Material ADM-S, Allograft Material ADM-D
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Jun 26, 2026, 2:45 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities

NCT05422742
View directory record Official record
Conditions
Periodontitis
Interventions
SRP + MM, Scaling and Root Planing (SRP)
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Jun 26, 2026, 2:45 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health

NCT04197427
View directory record Official record
Conditions
Plaque, Gingivitis
Interventions
Experimental Oral Rinse, Placebo
Device
Lead sponsor
You First Services
Industry
Eligibility
18 Years to 75 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery

NCT04957342
View directory record Official record
Conditions
Pain, Postoperative, Gingival Diseases
Interventions
amnion-chorion membrane, Sutures
Device · Procedure
Lead sponsor
Harvard Medical School (HMS and HSDM)
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Jun 26, 2026, 2:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum

NCT03945461
View directory record Official record
Conditions
Spondylosis, Spondylolisthesis, Neurogenic Claudication, Foraminal Stenosis
Interventions
Chewing gum
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Jun 26, 2026, 2:45 AM EDT
Completed No phase listed Observational

The Impact of Oral Health in HIV Patients on Antiretroviral Therapy

NCT04645693
View directory record Official record
Conditions
HIV, Periodontal Diseases, Caries, Non-communicable Disease, Xerostomia
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
227 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 26, 2026, 2:45 AM EDT