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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gut Permeability, Gut Inflammation Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

NCT07650058
View directory record Official record
Conditions
Healthy Participants
Interventions
High-Glycemic Breakfast Containing Cereal and Fresh Mango, High-Glycemic Breakfast Containing Cereal and Table Sugar
Other
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 45 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 24, 2026, 1:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease

NCT01155492
View directory record Official record
Conditions
Parkinson's Disease, Multiple System Atrophy
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D and Adipose Tissue Inflammation

NCT01477034
View directory record Official record
Conditions
Vitamin D Deficiency, Obesity, Type 2 Diabetes Mellitus, Intestinal Permeability
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 3, 2014 · Synced Jul 24, 2026, 1:19 AM EDT
Active, not recruiting Not applicable Interventional Results available

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

NCT05318183
View directory record Official record
Conditions
PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
Interventions
Whole Wheat Bread, White Bread (control)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Ability of a Multi-Strain Postbiotic to Impact Inflammation, Immune Components, Gastrointestinal Symptoms, Recovery, Anxiety, and Intestinal Permeability

NCT07387991
View directory record Official record
Conditions
Inflammation, Gastrointestinal Symptoms
Interventions
Multi-Strain Postbiotic, Placebo
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 24, 2026, 1:19 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Tributyrin: Time Course & Efficacy to Improve Health & Performance

NCT06501898
View directory record Official record
Conditions
Metabolite Concentration, Gut Permeability, Inflammation, Sleep, Performance
Interventions
CoreBiome, Placebo
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
30 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 12, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Diet and Systemic Inflammation

NCT01424306
View directory record Official record
Conditions
Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
Interventions
Fructose-sweetened beverages, Glucose-sweetened beverages, High-fructose corn syrup-sweetened beverages
Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 13, 2017 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Flavonoids on Gut Permeability in Cyclists

NCT03427879
View directory record Official record
Conditions
Gut Permeability, Gut Inflammation
Interventions
Low flavonoid beverage, High flavonoid beverage
Drug
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Jul 24, 2026, 1:19 AM EDT
Not listed No phase listed Observational

Gut Permeability-related Inflammation and Cardiovascular Disease Risk in Normal-weight and Metabolically Healthy Obesity

NCT05308394
View directory record Official record
Conditions
Obesity
Interventions
No experimental intervention will take place - the study is cross-sectional. Each participant will provide biological samples.
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Timeline
2022
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

NCT04543877
View directory record Official record
Conditions
Inflammation, Vaccine, Intestinal Permeability, Typhoid Fever
Interventions
Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
Dietary Supplement · Biological
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 59 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Not listed Not applicable Interventional

Intestinal Inflammation and Carbohydrate Digestion in Autistic Children

NCT00227487
View directory record Official record
Conditions
Autism, Inflammation
Interventions
Stool collection, Administration of carbohydrate solution during clinically indicated endoscopy, Questionnaires
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Months to 17 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts • Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Blueberry Consumption on Gastrointestinal Health

NCT03934177
View directory record Official record
Conditions
Obesity, Circadian Dysregulation
Interventions
Blueberry powder, Placebo powder
Dietary Supplement
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
19 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Early Phase 1 Interventional

Effects of a Western-type Diet on Colorectal Inflammation

NCT00866450
View directory record Official record
Conditions
Colorectal Inflammation
Interventions
Western style diet (high fat and low in calcium), Prudent-style diet (low fat and high in calcium)
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
50 Years to 72 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2012 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults

NCT03413735
View directory record Official record
Conditions
Obesity, Endotoxemia, Inflammation
Interventions
Green Tea Extract, Placebo
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 2 Interventional Results available

A Study of the Gut Barrier and Blood Vessel Inflammation in Individuals With and Without HIV

NCT02431325
View directory record Official record
Conditions
HIV
Interventions
Teduglutide, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of JuicePlus+ on the Health Status of an Overweight Stressed Population

NCT02512107
View directory record Official record
Conditions
Inflammation
Interventions
Juice Plus+, Placebo
Dietary Supplement · Other
Lead sponsor
University of Memphis
Other
Eligibility
25 Years to 50 Years · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 16, 2022 · Synced Jul 24, 2026, 1:19 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Induction of Gut Permeability by an Oral Vaccine

NCT04083950
View directory record Official record
Conditions
Intestinal Permeability, Inflammation, Vaccine, Typhoid Fever
Interventions
Vivotif Typhoid Oral Vaccine, Aspirin (Positive Control)
Biological · Drug
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 49 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 4 Interventional

Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB)

NCT04979130
View directory record Official record
Conditions
Type 2 Diabetes, Chronic Inflammation, Intestinal Permeability
Interventions
Semaglutide, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents

NCT07125001
View directory record Official record
Conditions
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
Interventions
Ataulfo mango
Other
Lead sponsor
University of California, Davis
Other
Eligibility
12 Years to 19 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jul 24, 2026, 1:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women

NCT06544954
View directory record Official record
Conditions
Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation, Permeability; Increased
Interventions
Freeze-dried grape powder, Placebo powder
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 24, 2026, 1:19 AM EDT