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ClinicalTrials.gov public records Last synced Nov 15, 2026, 9:34 AM EST

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Showing 25–48 of 72 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Gut Permeability Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D and Adipose Tissue Inflammation

NCT01477034
View directory record Official record
Conditions
Vitamin D Deficiency, Obesity, Type 2 Diabetes Mellitus, Intestinal Permeability
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 4, 2014 · Synced Nov 15, 2026, 9:34 AM EST
Not yet recruiting Not applicable Interventional

Impact of a Human Origin Heat Inactivated Probiotic-Lactobacillus Paracasei D3.5 (LpD3.5) as Dietary Supplement on Gut Mucin and Intestinal Permeability in Adults With IBD

NCT07017959
View directory record Official record
Conditions
Inflammatory Bowel Diseases
Interventions
LpD3.5 supplementation., Placebo
Dietary Supplement
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional

Dietary Intervention and Gastrointestinal Function in Patients With Parkinson's Disease

NCT03851861
View directory record Official record
Conditions
Parkinson Disease
Interventions
Mediterranean Diet
Other
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Nov 15, 2026, 9:34 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Gut, Immune, and Vascular Health in Metabolically Healthy Obesity

NCT07559227
View directory record Official record
Conditions
Metabolically Healthy Obesity
Interventions
Inulin Supplementation, Maltodextrin (Placebo), High-fat meal
Dietary Supplement · Other
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults

NCT03413735
View directory record Official record
Conditions
Obesity, Endotoxemia, Inflammation
Interventions
Green Tea Extract, Placebo
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Nov 15, 2026, 9:34 AM EST
Not listed No phase listed Observational

Gut Permeability-related Inflammation and Cardiovascular Disease Risk in Normal-weight and Metabolically Healthy Obesity

NCT05308394
View directory record Official record
Conditions
Obesity
Interventions
No experimental intervention will take place - the study is cross-sectional. Each participant will provide biological samples.
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Timeline
2022
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 15, 2022 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Effects of an Encapsulated Calcium Butyrate Dietary Supplement on Gut Health

NCT06397482
View directory record Official record
Conditions
Healthy, Gastrointestinal Discomfort
Interventions
Encapsulated Calcium Butyrate
Dietary Supplement
Lead sponsor
Kemin Foods LC
Industry
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Intestinal Permeability 4 Hours After Gluten Challenge

NCT03288831
View directory record Official record
Conditions
Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy, Immune System and Related Disorders, Duodenal Diseases
Interventions
Gluten, Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 7, 2019 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Blueberry Consumption on Gastrointestinal Health

NCT03934177
View directory record Official record
Conditions
Obesity, Circadian Dysregulation
Interventions
Blueberry powder, Placebo powder
Dietary Supplement
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
19 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Nov 15, 2026, 9:34 AM EST
Completed Phase 4 Interventional

Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB)

NCT04979130
View directory record Official record
Conditions
Type 2 Diabetes, Chronic Inflammation, Intestinal Permeability
Interventions
Semaglutide, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Nov 15, 2026, 9:34 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Gut Permeability Assessment in Celiac and Gluten Sensitive Children

NCT02690532
View directory record Official record
Conditions
Celiac Disease
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
2 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Nov 15, 2026, 9:34 AM EST
Completed Phase 2 Interventional Accepts healthy volunteers Results available

GI Permeability Change in Response to Aquamin®

NCT04855799
View directory record Official record
Conditions
Ulcerative Colitis, Healthy, Irritable Bowel Syndrome With Diarrhea
Interventions
Aquamin
Drug
Lead sponsor
James Varani
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Gut Permeability, Sensitivity and Symptomatology

NCT02358564
View directory record Official record
Conditions
Irritable Bowel Syndrome, Visceral Hypersensitivity
Interventions
Gastrointestinal Permeability Test, Upper Endoscopy, Rectal Barostat and Infusion of Fats
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Nov 15, 2026, 9:34 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

NCT07650058
View directory record Official record
Conditions
Healthy Participants
Interventions
High-Glycemic Breakfast Containing Cereal and Fresh Mango, High-Glycemic Breakfast Containing Cereal and Table Sugar
Other
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 45 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Nov 15, 2026, 9:34 AM EST
Not yet recruiting Not applicable Interventional

The Effects of Mango on Gut Health Markers

NCT07559604
View directory record Official record
Conditions
Gut Health, LBP, Short Chain Fatty Acids, sCD14
Interventions
Mango
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
40 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Nov 15, 2026, 9:34 AM EST
Completed Early Phase 1 Interventional Accepts healthy volunteers

A Study of Perturbation of Human Small Intestinal Colonic Permeability

NCT06033222
View directory record Official record
Conditions
Healthy
Interventions
Ricinoleic Acid 750 mg, Ricinoleic Acid 1500 mg, Ricinoleic Acid 3000 mg, Placebo
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Nov 15, 2026, 9:34 AM EST
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Flavonoids on Gut Permeability in Cyclists

NCT03427879
View directory record Official record
Conditions
Gut Permeability, Gut Inflammation
Interventions
Low flavonoid beverage, High flavonoid beverage
Drug
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Feb 25, 2021 · Synced Nov 15, 2026, 9:34 AM EST
Terminated Not applicable Interventional Accepts healthy volunteers

Tributyrin: Time Course & Efficacy to Improve Health & Performance

NCT06501898
View directory record Official record
Conditions
Metabolite Concentration, Gut Permeability, Inflammation, Sleep, Performance
Interventions
CoreBiome, Placebo
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
30 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2025 · Synced Nov 15, 2026, 9:34 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease

NCT01155492
View directory record Official record
Conditions
Parkinson's Disease, Multiple System Atrophy
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 30, 2013 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional

Betaine, Exercise Performance, and Gut Permeability

NCT06392360
View directory record Official record
Conditions
Metabolic Disturbance, Permeability; Increased
Interventions
Betaine, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Nov 15, 2026, 9:34 AM EST
Completed No phase listed Observational

Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin

NCT01558570
View directory record Official record
Conditions
Schizophrenia, Celiac Disease
Interventions
Blood Draw
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Nov 15, 2026, 9:34 AM EST
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Induction of Gut Permeability by an Oral Vaccine

NCT04083950
View directory record Official record
Conditions
Intestinal Permeability, Inflammation, Vaccine, Typhoid Fever
Interventions
Vivotif Typhoid Oral Vaccine, Aspirin (Positive Control)
Biological · Drug
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 49 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2026 · Synced Nov 15, 2026, 9:34 AM EST
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Ability of a Multi-Strain Postbiotic to Impact Inflammation, Immune Components, Gastrointestinal Symptoms, Recovery, Anxiety, and Intestinal Permeability

NCT07387991
View directory record Official record
Conditions
Inflammation, Gastrointestinal Symptoms
Interventions
Multi-Strain Postbiotic, Placebo
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Nov 15, 2026, 9:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults

NCT06437405
View directory record Official record
Conditions
LPS, Mood Disorders, Cognitive Change
Interventions
Vinegar liquid, vinegar pill
Dietary Supplement
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Nov 15, 2026, 9:34 AM EST