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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Gut Permeability Clear all
Completed No phase listed Observational Accepts healthy volunteers

Intestinal Permeability and Endometriosis

NCT03042923
View directory record Official record
Conditions
Endometriosis
Interventions
lactulose:mannitol (L:M) oral challenge
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Jul 25, 2026, 10:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease

NCT01155492
View directory record Official record
Conditions
Parkinson's Disease, Multiple System Atrophy
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Jul 25, 2026, 10:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Biomarkers for Intestinal Permeability in Patients With Constipation

NCT02246647
View directory record Official record
Conditions
Intestinal Diseases, Irritable Bowel Syndrome, Constipation
Interventions
Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
Diagnostic Test · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flavonoids, Exercise, Gut-Derived Phenolics

NCT03249571
View directory record Official record
Conditions
Exercise and Gut-derived Phenolics
Interventions
Flavonoid supplement, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

GI Permeability Change in Response to Aquamin®

NCT04855799
View directory record Official record
Conditions
Ulcerative Colitis, Healthy, Irritable Bowel Syndrome With Diarrhea
Interventions
Aquamin
Drug
Lead sponsor
James Varani
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Phase 4 Interventional Results available

Short Bowel Syndrome and Teduglutide Versus Placebo

NCT02099084
View directory record Official record
Conditions
Short Bowel Syndrome
Interventions
Teduglutide, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 21, 2016 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Blueberry Consumption on Gastrointestinal Health

NCT03934177
View directory record Official record
Conditions
Obesity, Circadian Dysregulation
Interventions
Blueberry powder, Placebo powder
Dietary Supplement
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
19 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Intestinal Permeability 4 Hours After Gluten Challenge

NCT03288831
View directory record Official record
Conditions
Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy, Immune System and Related Disorders, Duodenal Diseases
Interventions
Gluten, Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 6, 2019 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Alcohol, Gut Leakiness, & Liver Disease

NCT05428072
View directory record Official record
Conditions
Alcoholic Liver Disease
Interventions
Sugar test, Aspirin Challenge
Other · Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
195 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Jul 25, 2026, 10:29 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Tributyrin: Time Course & Efficacy to Improve Health & Performance

NCT06501898
View directory record Official record
Conditions
Metabolite Concentration, Gut Permeability, Inflammation, Sleep, Performance
Interventions
CoreBiome, Placebo
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
30 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 12, 2025 · Synced Jul 25, 2026, 10:29 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Exercise-Induced Gut Permeability in Normal-weight Obesity

NCT05889767
View directory record Official record
Conditions
Normal-weight Obesity, Obesity
Interventions
Exercise tests (VO2 max test and 45-minute exercise session at 65% VO2 max)
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional

Pilot Study of Diet and Behavior in Children With Autism

NCT01625299
View directory record Official record
Conditions
Autism
Interventions
Gluten and dry milk, Placebo
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Years to 12 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 20, 2012 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional

Dietary Intervention and Gastrointestinal Function in Patients With Parkinson's Disease

NCT03851861
View directory record Official record
Conditions
Parkinson Disease
Interventions
Mediterranean Diet
Other
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Jul 25, 2026, 10:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women

NCT06544954
View directory record Official record
Conditions
Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation, Permeability; Increased
Interventions
Freeze-dried grape powder, Placebo powder
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 25, 2026, 10:29 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Induction of Gut Permeability by an Oral Vaccine

NCT04083950
View directory record Official record
Conditions
Intestinal Permeability, Inflammation, Vaccine, Typhoid Fever
Interventions
Vivotif Typhoid Oral Vaccine, Aspirin (Positive Control)
Biological · Drug
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 49 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude

NCT04111263
View directory record Official record
Conditions
Gastrointestinal Injury, Acute Mountain Sickness
Interventions
FP, Placebo, High altitude, Sea level
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability

NCT03962998
View directory record Official record
Conditions
Crohn Disease
Interventions
Lactulose/Rhamnose solution, MB-102
Drug
Lead sponsor
MediBeacon
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Vitamin D Repletion in Chronic Kidney Disease

NCT00772772
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Vitamin D3
Drug
Lead sponsor
Rockefeller University
Other
Eligibility
50 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2015 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional

Betaine, Exercise Performance, and Gut Permeability

NCT06392360
View directory record Official record
Conditions
Metabolic Disturbance, Permeability; Increased
Interventions
Betaine, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Phase 2 Interventional Results available

Lubiprostone as a Modulator of Gut Microbial Translocation in HIV With Incomplete CD4 Recovery on Antiretroviral Therapy

NCT01839734
View directory record Official record
Conditions
HIV
Interventions
Lubiprostone
Drug
Lead sponsor
Ruth M. Rothstein CORE Center
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Flavonoids on Gut Permeability in Cyclists

NCT03427879
View directory record Official record
Conditions
Gut Permeability, Gut Inflammation
Interventions
Low flavonoid beverage, High flavonoid beverage
Drug
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Jul 25, 2026, 10:29 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Ability of a Multi-Strain Postbiotic to Impact Inflammation, Immune Components, Gastrointestinal Symptoms, Recovery, Anxiety, and Intestinal Permeability

NCT07387991
View directory record Official record
Conditions
Inflammation, Gastrointestinal Symptoms
Interventions
Multi-Strain Postbiotic, Placebo
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

NCT06419231
View directory record Official record
Conditions
Gut Health
Interventions
Butyrate Formulation, Butyrate + Polyphenol Formulation, Placebo
Dietary Supplement
Lead sponsor
Supplement Formulators, Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Jul 25, 2026, 10:29 AM EDT
Completed Phase 2 Interventional Results available

Does Welchol (Colesevelam Hydrochloride) Improve Colonic Transit in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS)?

NCT00911612
View directory record Official record
Conditions
Irritable Bowel Syndrome, Diarrhea
Interventions
Colesevelam, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 3, 2012 · Synced Jul 25, 2026, 10:29 AM EDT