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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Harm Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents

NCT01111734
View directory record Official record
Conditions
Deliberate Self Harm
Interventions
N-Acetylcysteine, fMRI
Dietary Supplement · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 21 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Phase 2 Interventional

Reduction of Smoking in Cardiac Disease Patients

NCT00469885
View directory record Official record
Conditions
Cardiovascular Disease, Tobacco Use Disorder
Interventions
Nicotine replacement, Motivational counseling
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
2
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Jun 26, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

NCT07199517
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
Interventions
HRP Sampling period, NPL Sampling period
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
472 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional

An Intuitive, Non-intrusive, Approach to Reduce Patient Harm From Inappropriate Dosing of High-risk Drugs in Older Adult Patients Across an Urban Safety Net Hospital System

NCT05218343
View directory record Official record
Conditions
Potentially Inappropriate Medications
Interventions
EHR-based "nudge" interventions
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
65 Years and older
Enrollment
8,640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

NCT00777569
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Results available

Virtual Hope Box - Effectiveness of a Smartphone App for Coping With Suicidal Ideation

NCT01982773
View directory record Official record
Conditions
Suicidal Ideation, Thoughts of Self Harm, Coping
Interventions
Virtual Hope Box Smartphone App, Enhanced Treatment as Usual
Behavioral
Lead sponsor
National Center for Telehealth and Technology
Federal
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Portland, Oregon • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 29, 2018 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes as a Harm Reduction Strategy

NCT06277271
View directory record Official record
Conditions
Smoking
Interventions
E-cigarette
Other
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Jun 26, 2026, 5:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Executive Dysfunction and Self-Harm Behavior: An Examination of Veterans With TBI, PTSD, or Both

NCT01334463
View directory record Official record
Conditions
Traumatic Brain Injury, Post Traumatic Stress Disorder, Suicide, Self-Injurious Behavior
Interventions
Not listed
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 45 Years
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 24, 2016 · Synced Jun 26, 2026, 5:36 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Clinical Alternatives for Reducing Harm Using E-cigarettes

NCT07039292
View directory record Official record
Conditions
Smoking, E-Cig Use, Oncology
Interventions
Harm Reduction (E-cigarette switching), Standard of Care
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jun 26, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional

Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A

NCT06223867
View directory record Official record
Conditions
Suicidal Ideation, Suicide Attempt, Self Harm
Interventions
Jaspr App + JAH, ETAU
Device · Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
670 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jun 26, 2026, 5:36 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study

NCT06074341
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Drinking, Alcohol-Related Disorders
Interventions
Mindfulness-based relapse prevention, Online Mutual Support Groups
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
470 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Results available

E-cigarettes for Harm Reduction in Adults With Asthma

NCT05278065
View directory record Official record
Conditions
Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional

Self-Esteem: A Protective Mechanism for Adolescent Mental Health

NCT04296812
View directory record Official record
Conditions
Self Esteem, Suicide and Self-harm
Interventions
Self-Love Model
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
14 Years to 17 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Jun 26, 2026, 5:36 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

An Augmented Reality Videogame for Alcohol Use Prevention and Harm Reduction in Teens

NCT04351958
View directory record Official record
Conditions
Alcohol Prevention, Harm Reduction
Interventions
Experimental: Augmented Reality ("No Time Wasted")
Behavioral
Lead sponsor
Yale University
Other
Eligibility
16 Years to 18 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers

NCT00711100
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Camel Snus, Marlboro Snus, Stonewall, Ariva, General Snus
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
Minneapolis, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Results available

Preventing Overdose Using Information and Data From the Environment

NCT05096429
View directory record Official record
Conditions
Opioid Overdose, Drug Overdose
Interventions
PROVIDENT
Behavioral
Lead sponsor
Brown University
Other
Eligibility
Not listed
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Jun 26, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional

Feasibility, Acceptability, and Preliminary Efficacy of a Novel Personalized Mobile Intervention for Suicide - Open Trial (2)

NCT05180344
View directory record Official record
Conditions
Suicide, Suicide and Self-harm, Suicide, Attempted, Suicidal Ideation
Interventions
Mobile Application to Prevent Suicide (MAPS)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 26 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrative Psychosocial Group Treatment

NCT03648177
View directory record Official record
Conditions
Chronic Pain, Opioid Misuse
Interventions
IPGT, Treatment as Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2019 · Synced Jun 26, 2026, 5:36 PM EDT
Completed No phase listed Observational

Improving Identification of Social Harm Among Substance Abusers in HIV Trials

NCT02148276
View directory record Official record
Conditions
Social Harms in Substance Users in HIV Trials, Audio Computer Assisted Self-administered Questionnaire
Interventions
Not listed
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Jun 26, 2026, 5:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Opioid Overdose Mortality in the United States

NCT03924505
View directory record Official record
Conditions
Opioid Overdose
Interventions
Organize and Mobilize for Implementation Effectiveness, Dissemination
Other
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Jun 26, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advancing Suicide Intervention Strategies for Teens During High Risk Periods

NCT05078970
View directory record Official record
Conditions
Suicide Attempts, Suicidal Ideation, Suicide and Self-harm, Suicide Threat
Interventions
Safety Planning Intervention+ (SPI+), Collaborative Assessment and Management of Suicidality (CAMS), Treatment As Usual
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 17 Years
Enrollment
306 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
2
States / cities
Columbus, Ohio • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT

NCT06088862
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, BIDI e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Switch or Quit R01

NCT06373679
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors
Interventions
Switching to E-Cigarette, Switching using Medication
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Jun 26, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional

Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs

NCT05800899
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Brief Motivational Interviewing, Culturally adaptation brief motivational interviewing
Behavioral
Lead sponsor
University of Texas, El Paso
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Jun 26, 2026, 5:36 PM EDT