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Showing 25–44 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Harmful Use Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Game Plan: Efficacy of a Brief, Web-based Intervention on Alcohol Use and Sexually-transmitted Infections

NCT04552171
View directory record Official record
Conditions
Sexually Transmitted Diseases, Bacterial, Alcohol; Harmful Use
Interventions
Access to Game Plan app and 24-hour helpline
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional

Adapting CBT-I for Hazardous Alcohol Users

NCT05973955
View directory record Official record
Conditions
Insomnia, Harmful; Use, Alcohol
Interventions
Insomnia Treatment, Education Control
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
25 Years to 64 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 12, 2026, 9:28 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sleep as a Mechanism of Change in Alcohol Use

NCT06286774
View directory record Official record
Conditions
Insomnia, Alcohol; Harmful Use
Interventions
Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 49 Years
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Understanding Alcohol Reward in Social Context

NCT03449095
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking
Interventions
Alcohol
Drug
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 30 Years
Enrollment
640 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional

Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification

NCT04263259
View directory record Official record
Conditions
Alcohol; Harmful Use
Interventions
Attentional Bias Modification
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 35 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Results available

Social Support Intervention for Addiction Recovery

NCT06022107
View directory record Official record
Conditions
Alcohol; Harmful Use, Alcohol
Interventions
LDART
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Family Based Prevention of Alcohol and Risky Sex for Older Teens

NCT03521115
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Intoxication, Alcohol Poison, Alcohol-Related Disorders, Alcohol Impairment, Alcohol Withdrawal, Alcohol Abstinence, Alcohol; Harmful Use, Sex Behavior, Sexual Aggression, Sexual Harassment, Relation, Interpersonal
Interventions
Smart Choices 4 Teens
Behavioral
Lead sponsor
Pacific Institute for Research and Evaluation
Other
Eligibility
16 Years to 17 Years
Enrollment
411 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 12, 2026, 9:28 AM EDT
Active, not recruiting Not applicable Interventional

Pain and Opioids: Integrated Treatment In Veterans

NCT04648228
View directory record Official record
Conditions
Chronic Pain, Opioid-use Disorder, Opioids; Harmful Use
Interventions
ACT+MBRP, Education control
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years to 75 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
San Francisco, California • Albuquerque, New Mexico • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Phase 1Phase 2 Interventional

Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use

NCT00907309
View directory record Official record
Conditions
Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
Interventions
iMET, iMET/TE
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 12, 2026, 9:28 AM EDT
Not listed Not applicable Interventional

Patient Education Video to Reduce OTC NSAIDs

NCT06575205
View directory record Official record
Conditions
Chronic Kidney Diseases, Heart Failure, Hypertension
Interventions
Educational video
Behavioral
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
1,452 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional

Testing A Couple-based Program for Alcohol Risk Reduction in the National Guard

NCT03589508
View directory record Official record
Conditions
Alcohol; Harmful Use
Interventions
In-person sessions: ABCP_P, Video conference sessions: ABCP_T
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Results available

HealthCall:Brief Intervention to Reduce Non-injecting Drug Use in HIV Primary Care Clinics

NCT01312181
View directory record Official record
Conditions
Mental and Behavioral Disorders Due to Harmful Drug Use
Interventions
HealthCall and Motivational Interviewing, Motivational Interviewing (MI), HIV/AIDS health education
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Sep 12, 2026, 9:28 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Reducing Hazardous Alcohol Use in Social Networks Using Targeted Intervention: 21 Rising

NCT04147520
View directory record Official record
Conditions
Alcohol Drinking, Alcohol; Harmful Use
Interventions
Brief Motivational Interview
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
1,475 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches

NCT05664672
View directory record Official record
Conditions
Tobacco Use
Interventions
OTDN Product 1, OTDN Product 2, OTDN Product 3, No Tobacco
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Phase 1 Interventional

Patient Driven Recovery With Nalmefene and Coaching

NCT03279562
View directory record Official record
Conditions
Opioid-use Disorder, Harmful; Use, Alcohol
Interventions
Nalmefene
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A PPG Sensor-Based Feedback Intervention for Heavy Drinking Young Adults

NCT05090995
View directory record Official record
Conditions
Heavy Drinking, Harmful; Use, Alcohol
Interventions
Behavioral Self-Management and Feedback, Behavioral Self-Management
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 25 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alcohol and Immune Response

NCT03483389
View directory record Official record
Conditions
Alcohol Drinking, Alcohol; Harmful Use
Interventions
Alcohol, Ethyl, Alcohol, Ethyl - placebo
Drug · Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 55 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Sep 12, 2026, 9:28 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

NCT07125534
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder (AUD), Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking
Interventions
Alcohol beverage, Control - non alcoholic beverage
Drug · Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 30 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 12, 2026, 9:28 AM EDT
Completed Phase 4 Interventional Results available

Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

NCT01750268
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Interventions
Medical Management Counseling, Topiramate, Placebo
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Sep 12, 2026, 9:28 AM EDT
Completed No phase listed Observational

Room Air Levels of Harmful and Potentially Harmful Constituents After Heated Tobacco Product Use and Cigarettes

NCT06476405
View directory record Official record
Conditions
Tobacco Smoking, Tobacco Use
Interventions
Not listed
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 12, 2026, 9:28 AM EDT