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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Healthy Smokers Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes

NCT04019626
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Continue-smoking, myblu Tobacco 2.5%, myblu Tobacco 4.0%, myblu Honeymoon 2.5%, myblu Honeymoon 4.0%, JUUL 5%
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
21 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

A Comparability Study of the Phase 3 Lot and a Single Commercial Lot of NicVAX in Healthy Adult Smokers

NCT01375933
View directory record Official record
Conditions
Smoking
Interventions
NicVAX Vaccine
Biological
Lead sponsor
Nabi Biopharmaceuticals
Industry
Eligibility
18 Years to 55 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
6
States / cities
Huntsville, Alabama • San Diego, California • Melbourne, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated May 13, 2012 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers

NCT02906995
View directory record Official record
Conditions
Tobacco Use Disorder, Cigarette Smoking
Interventions
Sublingual tablet 4 mg versus Nicorette Lozenge 4mg
Drug
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 3, 2017 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate Nicotine Uptake and Biomarkers in Adult Smokers Using mybluTM Electronic Cigarettes

NCT04429932
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Myblu flavor A_2.4, Myblu flavor B_2.4, Myblu flavor C_2.4, Myblu flavor D_2.4, Myblu flavor E_1.2, Myblu flavor F_1.2, Myblu flavor G_2.4, Myblu flavor H_2.4
Other
Lead sponsor
Fontem US LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 6, 2021 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 2 Interventional Results available

A Trial of Placebo Versus Enzastaurin for Lung Cancer Prevention in Former Smokers

NCT00414960
View directory record Official record
Conditions
Lung Cancer
Interventions
Enzastaurin, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
45 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Jul 21, 2026, 11:19 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Alternate Nicotine Delivery Systems and Airway Epithelial Biology

NCT01974063
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 2, 2018 · Synced Jul 21, 2026, 11:19 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Effects of Smoking Withdrawal On Resting State Functional Connectivity

NCT01632384
View directory record Official record
Conditions
Smoking
Interventions
Abstain from smoking for 24 hours
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers

NCT00565214
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
Group 1, Group 2
Dietary Supplement
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 70 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Jul 21, 2026, 11:19 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

NCT02585791
View directory record Official record
Conditions
Healthy Lifetime Non-smokers
Interventions
Propylene Glycol, vegetable glycerin, PG+VG
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 13, 2020 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers

NCT02575885
View directory record Official record
Conditions
Cigarette Smoker, Current Smoker, Healthy Subject
Interventions
Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study, Questionnaire Administration
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting

NCT01989156
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA)
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
22 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Daytona Beach, Florida • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Solarplast for Health and Oxidative Stress

NCT04144777
View directory record Official record
Conditions
Oxidative Stress, Healthy Aging, Skin Health
Interventions
Solarplast
Dietary Supplement
Lead sponsor
Deerland Enzymes
Industry
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Kennesaw, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 14, 2021 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations

NCT03087786
View directory record Official record
Conditions
Safety Issues
Interventions
Nicotine Bitartrate Lozenge 4mg, Nicotine Polacrilex 4Mg Lozenge
Drug
Lead sponsor
Niconovum USA
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 10, 2021 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 4 Interventional Results available

Smoking Cessation Study In Healthy Adolescent Smokers

NCT01312909
View directory record Official record
Conditions
Smoking Cessation
Interventions
Varenicline 1mg BID, Varenicline 0.5mg BID, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
12 Years to 19 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
56
States / cities
Ozark, Alabama • Goodyear, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) in Healthy Smokers

NCT03543137
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Prototype Mini lozenge, Nicorette Mini Lozenge
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
19 Years to 55 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Jul 21, 2026, 11:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Memory and Picture Viewing Study

NCT00736203
View directory record Official record
Conditions
Healthy, Brain Reactivity of Non-smokers Undergoing fMRI Scanning
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2013 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm

NCT01699607
View directory record Official record
Conditions
Nicotine Dependence, Healthy
Interventions
Amphetamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Jul 21, 2026, 11:19 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

NCT01776398
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Idiopathic Pulmonary Fibrosis (IPF), Rheumatoid Arthritis-Associated Interstitial Lung Disease, Scleroderma-Associated Interstitial Lung Disease (SSC-ILD)
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Food Effect and CYP1A2 Induction Study in Healthy Subjects

NCT02168205
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Pomalidomide, Caffeine, Tobacco
Drug · Other
Lead sponsor
Celgene
Industry
Eligibility
40 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Jul 21, 2026, 11:19 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers

NCT07215923
View directory record Official record
Conditions
Thromboangiitis Obliterans (Buerger's Disease)
Interventions
ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g), Placebo
Biological · Other
Lead sponsor
Antidote Therapeutics, Inc
Industry
Eligibility
23 Years to 59 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jul 21, 2026, 11:19 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Smoking-induced EGF-dependent Reprogramming of Airway Basal Cell Function

NCT01974180
View directory record Official record
Conditions
Smoking, COPD, Chronic Obstructive Pulmonary Disease
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 25, 2017 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Whole Body Periodic Acceleration on Airway Endothelial Function

NCT01213706
View directory record Official record
Conditions
Healthy, Smokers, Asthma
Interventions
Whole Body Periodic Acceleration (WBPA), Sham WBPA
Device
Lead sponsor
University of Miami
Other
Eligibility
20 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 9, 2016 · Synced Jul 21, 2026, 11:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease

NCT00974064
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD), Smoking, Smoking Cessation, Chronic Bronchitis, Emphysema
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 26, 2020 · Synced Jul 21, 2026, 11:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Bioequivalence Study of Two Nicotine Lozenges in Fasting Conditions in Healthy Smokers

NCT03541044
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Prototype Mini lozenge, Nicorette Mini Lozenge
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
19 Years to 55 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Jul 21, 2026, 11:19 AM EDT