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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Heart Arrest, Out-Of-Hospital Clear all
Not yet recruiting Phase 3 Interventional

Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest

NCT03176186
View directory record Official record
Conditions
Post-Cardiac Arrest Syndrome
Interventions
Xenon
Combination Product
Lead sponsor
Invero Pharma, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Hartford, Connecticut • Gainesville, Florida • Gulfport, Mississippi + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Jun 10, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Study the Feasibility and Acceptability of an App to Support Pediatric Resuscitation

NCT06768099
View directory record Official record
Conditions
Pediatric Emergency Medicine, Resuscitation, Pediatrics, Emergency Medical Services, Arrest Cardio Respiratory
Interventions
Linear Cognitive Aid
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jun 10, 2026, 12:02 AM EDT
Active, not recruiting Not applicable Interventional

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

NCT04217551
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
Interventions
Therapeutic Hypothermia
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
76
States / cities
Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Jun 10, 2026, 12:02 AM EDT
Not yet recruiting Not applicable Interventional

Ventilation Performance and Feedback Simulation Trial

NCT07352709
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest (OHCA)
Interventions
Real-time feedback
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Phase 3 Interventional Results available

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

NCT01401647
View directory record Official record
Conditions
Cardiac Arrest
Interventions
amiodarone, Lidocaine, Normal saline
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
3,024 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Birmingham, Alabama • San Diego, California • Portland, Oregon + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jun 10, 2026, 12:02 AM EDT
Active, not recruiting No phase listed Observational

End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

NCT07632430
View directory record Official record
Conditions
Prehospital Resuscitation, End-Tidal Carbon Dioxide, Cardiac Arrest, Out-Of-Hospital, Prehospital Emergency Medical Services
Interventions
Not listed
Lead sponsor
Office of the Medical Director for EMS in Oklahoma City and Tulsa
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Phase 2 Interventional

Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients

NCT00879892
View directory record Official record
Conditions
Ischemic Brain Injury
Interventions
xenon, Hypothermia
Drug · Other
Lead sponsor
Turku University Hospital
Government
Eligibility
18 Years to 80 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest

NCT03452917
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest
Interventions
Placebo, sodium nitrite 45 mg, sodium nitrite 60 mg
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest

NCT01413399
View directory record Official record
Conditions
Out-of-Hospital Cardiac Arrest
Interventions
4 degree chilled saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 110 Years
Enrollment
542 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Phase 4 Interventional Results available

Continuous Chest Compressions vs AHA Standard CPR of 30:2

NCT01372748
View directory record Official record
Conditions
Out of Hospital Cardiac Arrest
Interventions
Standard CPR, Continuous chest compressions
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
23,711 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Birmingham, Alabama • Pittsburgh, Pennsylvania • Dallas, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2016 · Synced Jun 10, 2026, 12:02 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gathering Evidence on Best Practices for Lay Rescuer CPR Training

NCT05908500
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
CPR Training, CPR Manikin Type
Behavioral · Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
Not listed
Enrollment
2,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Jun 10, 2026, 12:02 AM EDT
Terminated Not applicable Interventional Results available

ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest

NCT00189423
View directory record Official record
Conditions
Heart Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, Cardiac Arrest
Interventions
Use of an impedance threshold device (ITD) during the performance of active compression decompression CPR (ACD-CPR), Standard cardiopulmonary resuscitation (S-CPR)
Device · Procedure
Lead sponsor
Advanced Circulatory Systems
Industry
Eligibility
18 Years and older
Enrollment
1,653 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
7
States / cities
Indianapolis, Indiana • Ann Arbor, Michigan • Royal Oak, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2017 · Synced Jun 10, 2026, 12:02 AM EDT
Completed No phase listed Observational

Effect of Pre-imaging on Cardiopulmonary Resuscitation (CPR) Pause

NCT04248985
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Pre-Imaging - an ultrasound technique of acquiring images
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Jun 10, 2026, 12:02 AM EDT
Terminated Not applicable Interventional Results available

Advanced Reperfusion Strategies for Refractory Cardiac Arrest

NCT03880565
View directory record Official record
Conditions
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia, Out-Of-Hospital Cardiac Arrest
Interventions
Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Phase 1 Interventional

Phase 1 Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest

NCT02987088
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest
Interventions
Sodium Nitrite
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Jun 10, 2026, 12:02 AM EDT
Suspended Not applicable Interventional

Pediatric Prehospital Airway Resuscitation Trial

NCT06364280
View directory record Official record
Conditions
Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only, Critical Illness
Interventions
BVM, SGA, ETI
Device
Lead sponsor
Ohio State University
Other
Eligibility
24 Hours to 17 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
10
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Not applicable Interventional Results available

Pragmatic Airway Resuscitation Trial

NCT02419573
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Endotracheal Intubation, Laryngeal Tube (King)
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
3,004 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
6
States / cities
Birmingham, Alabama • Portland, Oregon • Pittsburgh, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2019 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Not applicable Interventional Results available

Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest

NCT01325870
View directory record Official record
Conditions
Cardiac Arrest, Sudden Cardiac Death
Interventions
ACD-CPR, ITPR, S-CPR, Impedance Threshold Device (ITD)
Device · Procedure
Lead sponsor
Advanced Circulatory Systems
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Kalamazoo, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 11, 2016 · Synced Jun 10, 2026, 12:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Arizona Prehospital CPR Quality Improvement Project

NCT01258244
View directory record Official record
Conditions
Out-of-Hospital Cardiac Arrest
Interventions
Audiovisual Feedback
Other
Lead sponsor
Valleywise Health
Other
Eligibility
24 Years to 55 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
2
States / cities
Flagstaff, Arizona • Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jun 10, 2026, 12:02 AM EDT
Enrolling by invitation Not applicable Interventional

RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems

NCT04660526
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use., Optimized first responder performance including earlier use of AEDs.
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 10, 2026, 12:02 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest

NCT00391469
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest
Interventions
Rapid infusion of 2 liters of 4oC normal saline, Rapid infusion of cold normal saline
Other · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Jun 10, 2026, 12:02 AM EDT
Terminated Phase 2 Interventional Results available

Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest

NCT03079102
View directory record Official record
Conditions
Heart Arrest, Out-Of-Hospital
Interventions
Nitric Oxide, Nitrogen
Drug
Lead sponsor
Cameron Dezfulian
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
McKeesport, Pennsylvania • Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 24, 2022 · Synced Jun 10, 2026, 12:02 AM EDT