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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Heart Failure (HF) Clear all
Terminated Phase 2 Interventional Results available

Effectiveness of CRD-740 in Heart Failure

NCT05409183
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
Interventions
CRD-740, Placebo
Drug
Lead sponsor
Cardurion Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
17
States / cities
Alexander City, Alabama • Birmingham, Alabama • Fairhope, Alabama + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Jun 26, 2026, 1:23 PM EDT
Terminated Phase 2 Interventional Results available

Subcutaneous Furosemide in Acute Decompensated Heart Failure: The SUBQ-HF Study

NCT03170219
View directory record Official record
Conditions
Acute Heart Failure, Decompensated Heart Failure
Interventions
subcutaneous furosemide and sc2wear device
Combination Product
Lead sponsor
Adrian Hernandez
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
16
States / cities
Atlanta, Georgia • Chicago, Illinois • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Contribution of Endothelin-1 to Exercise Intolerance in Heart Failure

NCT02124824
View directory record Official record
Conditions
Heart Failure
Interventions
BQ-123
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 19, 2021 · Synced Jun 26, 2026, 1:23 PM EDT
Active, not recruiting Not applicable Interventional

RESPONDER-HF Trial

NCT05425459
View directory record Official record
Conditions
Heart Failure, Heart Failure, Diastolic
Interventions
Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Device · Other
Lead sponsor
Corvia Medical
Industry
Eligibility
40 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
33
States / cities
Phoenix, Arizona • La Jolla, California • Long Beach, California + 28 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Recruiting Phase 2 Interventional

The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)

NCT05562167
View directory record Official record
Conditions
Heart Failure
Interventions
KNO3, Placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
19 Years to 79 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Not applicable Interventional

EHR Nudges to Improve Quality of Care in HF

NCT06103565
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
Clinical Decision Support Tool
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Phase 4 Interventional Results available

Response of Cardiac Resynchronization Therapy Optimization With Ventricle to Ventricle Timing in Heart Failure Patients

NCT00187200
View directory record Official record
Conditions
Heart Failure
Interventions
Simultaneous VV Pacing, Sequential VV Pacing
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
816 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Jun 26, 2026, 1:23 PM EDT
Not yet recruiting No phase listed Observational

Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation

NCT07436299
View directory record Official record
Conditions
Heart Failure (HF), Atrial Fibrillation (AF)
Interventions
Not listed
Lead sponsor
Oslo University Hospital
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Cleveland, Ohio • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Phase 3 Interventional Results available

Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)

NCT03988634
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions
sacubitril/valsartan, valsartan, sacubitril/valsartan matching placebo, valsartan matching placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 99 Years
Enrollment
467 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
87
States / cities
Irvine, California • Long Beach, California • Los Angeles, California + 77 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Jun 26, 2026, 1:23 PM EDT
Not yet recruiting Not applicable Interventional

Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction

NCT07644806
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction (HFrEF)
Interventions
Extra-virgin olive oil
Other
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Terminated Not applicable Interventional Results available

Evaluation of Cardiac Compass With OptiVol in the Early Detection of Decompensation Events for Heart Failure

NCT00510198
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
Cardiac Compass with OptiVol Fluid Status Monitoring, Standard of Care alone (clinical assessment)
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
33
States / cities
Anchorage, Alaska • Little Rock, Arkansas • Berkeley, California + 30 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jun 26, 2026, 1:23 PM EDT
Completed No phase listed Observational

Link-HF: Multisensor Non-invasive Telemonitoring System for Prediction of Heart Failure Exacerbation

NCT03037710
View directory record Official record
Conditions
Cardiac Failure
Interventions
HealthPatch
Device
Lead sponsor
Josef Stehlik
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
4
States / cities
Palo Alto, California • Gainesville, Florida • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program

NCT04281849
View directory record Official record
Conditions
Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure，Congestive, Heart Failure; With Decompensation, Heart Failure Acute, Heart Failure With Reduced Ejection Fraction
Interventions
BAMS-HF Program
Behavioral
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
55 Years to 100 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Jun 26, 2026, 1:23 PM EDT
No Longer Available No phase listed Expanded access

Multiple Patient Program to Ensure Access to LCZ696 Treatment to Patients Diagnosed With Heart Failure With Reduced Ejection Fraction (HF-rEF)

NCT02389933
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction (HF-rEF)
Interventions
LCZ696
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Vero Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2021 · Synced Jun 26, 2026, 1:23 PM EDT
Active, not recruiting Not applicable Interventional

REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)

NCT05652218
View directory record Official record
Conditions
Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block
Interventions
LB-CRT, BIV-CRT
Device
Lead sponsor
Inova Health Care Services
Other
Eligibility
Not listed
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Durham, North Carolina • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Recruiting Phase 3 Interventional

A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction

NCT07188805
View directory record Official record
Conditions
Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
Interventions
Finerenone (Kerendia, BAY94-8862), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
6 Months to 17 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
22
States / cities
Aurora, Colorado • Wilmington, Delaware • Gainesville, Florida + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure

NCT06457152
View directory record Official record
Conditions
Heart Failure
Interventions
EHR-Emedded Alert
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
1,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • New York, New York • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Motivational Interviewing Tailored Intervention for Patients With Heart Failure (MITI-HF)

NCT02177656
View directory record Official record
Conditions
Heart Failure
Interventions
Motivational Interviewing tailored intervention
Behavioral
Lead sponsor
Ruth Masterson-Creber
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 26, 2014 · Synced Jun 26, 2026, 1:23 PM EDT
Completed No phase listed Observational

Correlation of SOZO BIS Measures With CardioMEMS PA Pressure

NCT02939053
View directory record Official record
Conditions
NYHA Class III Heart Failure
Interventions
SOZO
Device
Lead sponsor
ImpediMed Limited
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Rochester, Minnesota • Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2019 · Synced Jun 26, 2026, 1:23 PM EDT
Recruiting Not applicable Interventional

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

NCT07086131
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
Powerbreathe
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Not applicable Interventional

Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart Failure

NCT06592508
View directory record Official record
Conditions
Heart Failure; With Decompensation
Interventions
Remote Virtual Cardiology Program
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
5
States / cities
Panama City, Florida • Gainesville, Georgia • Raleigh, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)

NCT06118983
View directory record Official record
Conditions
Heart Failure
Interventions
I-TRANSFER-HF
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
1,094 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jun 26, 2026, 1:23 PM EDT
Completed No phase listed Observational

REGISTRY EVALUATION OF VITAL INFORMATION FOR VADs IN AMBULATORY LIFE

NCT01369407
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
No Intervention
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
21
States / cities
Birmingham, Alabama • Beverly Hills, California • Aurora, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Jun 26, 2026, 1:23 PM EDT
Completed Not applicable Interventional Results available

The Cascade Feasibility Pilot (HF) Phase 3

NCT04993287
View directory record Official record
Conditions
Heart Failure
Interventions
Non-invasive continuous remote monitoring with structured escalation pathway, Affective Analysis of Participant Response to Continuous Remote Patient Monitoring
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 100 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Jun 26, 2026, 1:23 PM EDT