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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Heart Valve Replacement Clear all
Not listed Not applicable Interventional

Coronary Access After Supra-Annular THV Implantation

NCT05075590
View directory record Official record
Conditions
Coronary Angiography, Transcatheter Aortic Valve Replacement
Interventions
Coronary Angiography
Diagnostic Test
Lead sponsor
University of British Columbia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Harrisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 19, 2023 · Synced Jul 21, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Hemodynamic Comparison of Tissue Aortic Valves

NCT01635244
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Aortic valve replacement
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Jul 21, 2026, 4:52 PM EDT
Active, not recruiting Not applicable Interventional Results available

SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial

NCT04722250
View directory record Official record
Conditions
Symptomatic Aortic Stenosis, Aortic Valve Stenosis, Aortic Valve Replacement
Interventions
Medtronic Evolut PRO, Evolut PRO+ or Evolut FX (where commercially available) TAV Systems, Edwards SAPIEN 3 or SAPIEN 3 Ultra THV Systems
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
18 Years and older
Enrollment
1,103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
61
States / cities
La Jolla, California • Los Angeles, California • San Francisco, California + 47 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 21, 2026, 4:52 PM EDT
Active, not recruiting No phase listed Observational

Acute Kidney Injury Genomics and Biomarkers in TAVR Study

NCT02791880
View directory record Official record
Conditions
Acute Kidney Injury, Renal Insufficiency, Chronic, Heart Failure, Myocardial Infarction, Arrhythmias, Cardiac, Stroke
Interventions
Transcatheter Aortic Valve Replacement
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2031
U.S. locations
3
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Jul 21, 2026, 4:52 PM EDT
Recruiting No phase listed Observational

STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)

NCT01737528
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Transcatheter Aortic Valve Replacement
Procedure
Lead sponsor
The Society of Thoracic Surgeons
Other
Eligibility
18 Years and older
Enrollment
16,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2035
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Jul 21, 2026, 4:52 PM EDT
Terminated Not applicable Interventional

A STEP for Patients Prior to Undergoing TAVR: A Pilot Study

NCT02766075
View directory record Official record
Conditions
Frail Elderly, Aortic Valve Stenosis
Interventions
Supervised TAVR Exercise Program
Behavioral
Lead sponsor
OSF Healthcare System
Other
Eligibility
50 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Jul 21, 2026, 4:52 PM EDT
Completed Not applicable Interventional

A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement

NCT03270124
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Daily Activity Goal, Resistance Exercises, Daily Activity Recording
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
Boston, Massachusetts • Lebanon, New Hampshire • Morristown, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Jul 21, 2026, 4:52 PM EDT
Completed No phase listed Observational

Pacemaker Utilization and Ventricular Pacing in Patients Undergoing Trans-catheter Aortic Valve Replacement (TAVR)

NCT02994667
View directory record Official record
Conditions
Ventricular Flutter, Atrioventricular Block, Intraventricular Conduction Delay, Bundle Branch Block, Pacemaker Implantation
Interventions
Permanent Pacemaker Placement
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Jul 21, 2026, 4:52 PM EDT
Recruiting Not applicable Interventional

Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

NCT07230964
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Impedance Cardiography Upright/Supine Test
Device
Lead sponsor
Dermed Diagnostics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 21, 2026, 4:52 PM EDT
Terminated Not applicable Interventional Results available

Artificial Valve Endocarditis Reduction Trial

NCT00590889
View directory record Official record
Conditions
Aortic Valve Disease, Mitral Valve Disease, Endocarditis
Interventions
Artificial Mechanical Heart Valve
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
807 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2014
U.S. locations
7
States / cities
Orlando, Florida • Boston, Massachusetts • Rochester, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Jul 21, 2026, 4:52 PM EDT
Recruiting Not applicable Interventional

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

NCT04634240
View directory record Official record
Conditions
Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
Interventions
Percutaneous Coronary Intervention (PCI)
Procedure
Lead sponsor
University of British Columbia
Other
Eligibility
Not listed
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
55
States / cities
Huntsville, Alabama • Phoenix, Arizona • Palo Alto, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 21, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

The ShortCut™ Study Protocol

NCT04952909
View directory record Official record
Conditions
Risk of Coronary Obstruction Following Transcatheter Aortic Valve Replacement (TAVR) Procedure
Interventions
ShortCut™
Device
Lead sponsor
Pi-cardia
Industry
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
13
States / cities
Tucson, Arizona • Los Angeles, California • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Jul 21, 2026, 4:52 PM EDT
Not listed Not applicable Interventional

Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial

NCT05230225
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Physician Notification Letter
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2022 · Synced Jul 21, 2026, 4:52 PM EDT
Completed No phase listed Observational

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

NCT04827238
View directory record Official record
Conditions
Aortic Stenosis, Aortic Valve Stenosis
Interventions
Standardized Invasive Hemodynamics
Diagnostic Test
Lead sponsor
University of British Columbia
Other
Eligibility
Not listed
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
Tucson, Arizona • Boca Raton, Florida • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 21, 2026, 4:52 PM EDT
Completed Not applicable Interventional

Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement

NCT02971020
View directory record Official record
Conditions
Cardiovascular Disease, Aortic Valve Stenosis, Cognitive Assessments, Valve Surgery, Transcatheter Valve Replacement, Surgical Valve Replacement
Interventions
Observational/Cognitive Assessment
Other
Lead sponsor
Minnesota Veterans Medical Research and Education Foundation
Other
Eligibility
Up to 104 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 25, 2018 · Synced Jul 21, 2026, 4:52 PM EDT
Not listed Not applicable Interventional

Transcatheter Aortic Valve Replacement System Pivotal Trial

NCT02163850
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Direct Flow Medical, Commercially Available
Device
Lead sponsor
Direct Flow Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
878 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
3
States / cities
New York, New York • Columbus, Ohio • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 2, 2016 · Synced Jul 21, 2026, 4:52 PM EDT
Not listed Not applicable Interventional

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

NCT04770961
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions
Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Jul 21, 2026, 4:52 PM EDT
Not listed Phase 2 Interventional

Confirmation Trial of the Acorn CorCap Cardiac Support Device (CSD) at the Same Time as Mitral Valve Repair

NCT00630266
View directory record Official record
Conditions
Heart Failure
Interventions
CorCap CSD
Device
Lead sponsor
Acorn Cardiovascular, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
11
States / cities
Santa Clara, California • Oak Lawn, Illinois • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2009 · Synced Jul 21, 2026, 4:52 PM EDT
Terminated Not applicable Interventional

Perceval S Aortic Heart Valve Study- North America

NCT01810679
View directory record Official record
Conditions
Aortic Valve Stenosis, Aortic Valve Stenosis With Insufficiency, Regurgitation, Aortic Valve, Aortic Valve Incompetence
Interventions
Perceval S Aortic Heart Valve
Device
Lead sponsor
Sorin Group USA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
355 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
21
States / cities
Opelika, Alabama • Tucson, Arizona • Aurora, Colorado + 16 more
Source: ClinicalTrials.gov public record
Updated Nov 15, 2016 · Synced Jul 21, 2026, 4:52 PM EDT
Terminated Not applicable Interventional Results available

CarboMedics Top Hat vs St. Jude Medical Regent Valve Comparing Sizing and Hemodynamics

NCT00619151
View directory record Official record
Conditions
Aortic Valve Disease
Interventions
Top Hat, Regent
Device
Lead sponsor
Sorin Group USA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
Baltimore, Maryland • Kingsport, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 15, 2011 · Synced Jul 21, 2026, 4:52 PM EDT
Active, not recruiting No phase listed Observational

Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

NCT05526560
View directory record Official record
Conditions
Mitral Stenosis, Mitral Valve Insufficiency
Interventions
MITRIS RESILIA Mitral Valve, Model 11400M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
504 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2035
U.S. locations
20
States / cities
Newport Beach, California • Palo Alto, California • Orlando, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 21, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Controlled Arterial Protection to Ultimately Remove Embolic Material

NCT06103591
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
The EmStop Embolic Protection System (EmStop System)
Device
Lead sponsor
EmStop Inc
Industry
Eligibility
21 Years to 90 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Asheville, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Jul 21, 2026, 4:52 PM EDT
Active, not recruiting Not applicable Interventional

Edwards EVOQUE Eos MISCEND Study

NCT02718001
View directory record Official record
Conditions
Mitral Valve Regurgitation (Degenerative or Functional)
Interventions
Edwards EVOQUE Eos Mitral Valve Replacement System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2033
U.S. locations
16
States / cities
Burlingame, California • Los Angeles, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 4:52 PM EDT
Active, not recruiting Not applicable Interventional

Evaluation of the GORE PV1 Device in Patients With Pulmonary Valve Dysfunction

NCT03441971
View directory record Official record
Conditions
Heart Defects, Congenital, Tetralogy of Fallot, Pulmonary Valve Insufficiency, Pulmonary Valve Stenosis
Interventions
GORE PV1
Device
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
5 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
3
States / cities
Chicago, Illinois • Boston, Massachusetts • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 21, 2026, 4:52 PM EDT