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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Herniation, Disc Clear all
Terminated Not applicable Interventional

Chiropractic Prone Distraction for Lower Back Pain

NCT00269503
View directory record Official record
Conditions
Herniated Disc, Lower Back Pain, Sciatica
Interventions
Prone Distraction, Side-Posture Manipulation, Side-Posture Manipulation & Prone Distraction, Usual Care (Control Group)
Procedure
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 7, 2008 · Synced Jul 22, 2026, 11:53 AM EDT
Recruiting No phase listed Observational

Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

NCT05701059
View directory record Official record
Conditions
Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
Interventions
Cervical arthroplasty, Semi-Constrained Nuvasive Simplify, Unconstrained Biomet Zimmer Mobi-C
Procedure · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Phase 4 Interventional

CLARIX™ 100 & CLARIX CORD 1K for Discectomy Patients

NCT03113786
View directory record Official record
Conditions
Protruded Disk
Interventions
CLARIX™100, CLARIX CORD 1K
Other
Lead sponsor
Amniox Medical, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Bensalem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Phase 1Phase 2 Interventional

Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation

NCT01240876
View directory record Official record
Conditions
Sciatica
Interventions
CEP-37247, Placebo
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 70 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
20
States / cities
La Mesa, California • Laguna Hills, California • Pasadena, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2016 · Synced Jul 22, 2026, 11:53 AM EDT
Terminated Not applicable Interventional Results available

Dexamethasone Versus Depo Medrol in Lumbar Epidurals

NCT01397552
View directory record Official record
Conditions
Lumbar Spine Disc Herniation, Lumbar Radiculitis, Lumbar Back Pain
Interventions
Dexamethasone, methylprednisolone acetate
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
21 Years to 89 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
East Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Jul 22, 2026, 11:53 AM EDT
Recruiting Not applicable Interventional

PREventing Pain After Surgery

NCT05306665
View directory record Official record
Conditions
Pain, Back, Spinal Stenosis, Disc Herniation, Spondylosis, Spondylolisthesis, Back Injuries
Interventions
ACT intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
22 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2024 · Synced Jul 22, 2026, 11:53 AM EDT
Terminated Phase 4 Interventional Results available

CT Guided Injection for Low Back Radiculopathy: A Randomized Clinical Trial

NCT01267825
View directory record Official record
Conditions
Disc Herniation, Lumbosacral Radiculopathy
Interventions
CT-guided corticosteroid+ bupivicaine, Standard medical care
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
21 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Jul 22, 2026, 11:53 AM EDT
Not listed Not applicable Interventional

Study of Lumbar Discectomy With Annular Closure

NCT03986580
View directory record Official record
Conditions
Lumbar Disc Herniation
Interventions
Annular closure device
Device
Lead sponsor
Intrinsic Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
7
States / cities
San Diego, California • Jacksonville, Florida • Evanston, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jul 22, 2026, 11:53 AM EDT
Terminated No phase listed Observational

Lumbar Disc Herniation Outcome Measures

NCT01041391
View directory record Official record
Conditions
Lumbar Intervertebral Disc Herniation
Interventions
Discectomy-lumbar spine
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 90 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2018 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Phase 3 Interventional

Neurosurgery Patient Outcomes in Treating Spinal Disorders

NCT01220921
View directory record Official record
Conditions
Symptomatic Lumbar Disc Herniation, Symptomatic Grade I Lumbar Spondylolisthesis
Interventions
Lumbar Discectomy, Single-level lumbar fusion
Procedure
Lead sponsor
Greenwich Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
12
States / cities
San Francisco, California • Greenwich, Connecticut • New Haven, Connecticut + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Jul 22, 2026, 11:53 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Neural Control and Mechanosensation in Spine Muscle

NCT07003802
View directory record Official record
Conditions
Low Back Pain and Core Muscle, Disc Herniation
Interventions
Resistance exercise
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 60 Years
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 22, 2026, 11:53 AM EDT
Terminated Not applicable Interventional Results available

Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease

NCT02070484
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Spondylosis, Intervertebral Disk Displacement, Intervertebral Disk Degeneration, Spinal Diseases, Bone Diseases, Musculoskeletal Diseases, Spondylolysis
Interventions
NuCel, Demineralized Bone Matrix
Biological
Lead sponsor
OhioHealth
Other
Eligibility
18 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Jul 22, 2026, 11:53 AM EDT
Not listed Not applicable Interventional

Short Versus Long Post-Operative Restrictions Following Lumbar Discectomy

NCT01363830
View directory record Official record
Conditions
Lumbar Disc Herniation
Interventions
Two-Week Post-Operative Restriction, Six-Week Post-Operative Restriction
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2013 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Not applicable Interventional

A Comparison Study Between Contrast Spread and Loss of Resistance Techniques

NCT05260294
View directory record Official record
Conditions
Cervical Radiculopathy, Neck Pain, Disc Prolapse With Radiculopathy
Interventions
Epidural space identification with cervical epidural steroid injection employing CST and LORT.
Procedure
Lead sponsor
Yakov Perper, MD
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Astoria, New York
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jul 22, 2026, 11:53 AM EDT
Not listed No phase listed Observational

Lumbar Discectomy Control Study, Risk Factors for Reherniation

NCT02477176
View directory record Official record
Conditions
Lumbar Spine Disc Herniation
Interventions
Discectomy
Other
Lead sponsor
Intrinsic Therapeutics
Industry
Eligibility
21 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Galena, Kansas • Paducah, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jul 22, 2026, 11:53 AM EDT
Completed No phase listed Observational Results available

Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device

NCT01944345
View directory record Official record
Conditions
Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1, Intervertebral Disc Displacement
Interventions
Not listed
Lead sponsor
Wenzel Spine
Industry
Eligibility
18 Years to 99 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Boston, Massachusetts • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Phase 4 Interventional

Treatment of Chronic Thoracic and Neck and Upper Extremity Pain

NCT01071369
View directory record Official record
Conditions
Back Pain, Neck Pain
Interventions
Xylocaine, Xylocaine and Celestone
Drug
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 26, 2017 · Synced Jul 22, 2026, 11:53 AM EDT
Withdrawn Phase 3 Interventional

Peri-Incisional Drug Injection in Lumbar Spine Surgery

NCT03513445
View directory record Official record
Conditions
Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions
Morphine, Epinephrine, naropin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Jul 22, 2026, 11:53 AM EDT
Withdrawn Not applicable Interventional

Comparison of Three Approaches of Electrode Placement to Detect Changes in Motor Evoked Potentials During Spine Surgery

NCT05098431
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Stenosis, Spinal Curvatures, Spondylitis, Spondylosis
Interventions
Quadriceps and Rectus Femoris MEP Recording
Other
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Jul 22, 2026, 11:53 AM EDT
Completed No phase listed Observational

Perioperative Local Anesthesia Block in Spine Surgery

NCT05094427
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Disc Herniation, Lumbar Spinal Stenosis
Interventions
Preoperative fluoroscopically-guided dorsal ramus block placed by the operative neurosurgeon
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
232 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Jul 22, 2026, 11:53 AM EDT
Completed No phase listed Observational

PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries

NCT01406405
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Posterior/Transforaminal Lumbar Interbody Fusion (P/TLIF), Anterior Cervical Discectomy and Fusion (ACDF)
Procedure
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Not applicable Interventional

Sustained Acoustic Medicine for Chronic Low Back Pain Secondary to Herniated Nucleus Pulposus or Other Conditions

NCT02609854
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP), Intervertebral Disc Displacement
Interventions
Sustained Acoustic Medicine (SAM), Sham Device
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Dryden, New York • Chapel Hill, North Carolina • Ogden, Utah
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Jul 22, 2026, 11:53 AM EDT
Completed Phase 3 Interventional Results available

SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)

NCT03607838
View directory record Official record
Conditions
Lumbar Disc Herniation
Interventions
SI-6603, Sham injection
Drug
Lead sponsor
Seikagaku Corporation
Industry
Eligibility
30 Years to 70 Years
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
67
States / cities
Mobile, Alabama • Fountain Valley, California • La Jolla, California + 60 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 22, 2026, 11:53 AM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

NCT05444751
View directory record Official record
Conditions
Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
Interventions
General anesthetic, SA + ESP
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jul 22, 2026, 11:53 AM EDT