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ClinicalTrials.gov public records Last synced Nov 4, 2026, 1:12 PM EST

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Showing 1–24 of 90 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Hypoxic-Ischemic Encephalopathy Clear all

Conditions: Hypoxia-Ischemia, Brain, Signs and Symptoms
Interventions: Diffuse optical spectroscopy; Device
Lead sponsor: University of California, Irvine; Other
Eligibility: 20 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Irvine, California

Conditions: Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Interventions: Prospective Clinical and Neurodevelopmental Data Collection; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 31 Weeks to 42 Weeks
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypoxic-Ischemic Encephalopathy, Brain Ischemia Hypoxia
Interventions: Sulfur hexafluoride lipid-type A microspheres; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 1 Minute to 18 Months
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Acute Anoxic Encephalopathy
Interventions: Indocyanine Green; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
Interventions: EEG, NIRS; Device
Lead sponsor: Sharp HealthCare; Other
Eligibility: Up to 72 Hours
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: San Diego, California

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: Darbepoetin alfa, Placebo; Drug
Lead sponsor: University of Utah; Other
Eligibility: Up to 24 Hours
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 7
States / cities: Albuquerque, New Mexico • Nashville, Tennessee • Ogden, Utah + 3 more

Conditions: Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder), Cerebral Palsy (CP), Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment, Cerebral Palsy Infantile, Cerebral Palsy Spastic Hemiplegic, Cerebral Palsy, Dyskinetic, Autism Spectrum Disorder, Autism Spectrum Disorder (ASD, Hypoxic Ischemic Encephalopathy, Hypoxic Ischemic Encephalopathy (HIE), Traumatic Brain Injury (TBI), Sensory Processing Disorder, Chromosomal Abnormalities, Genetic Disorders, Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS), RETT Syndrome With Proven MECP2 Mutation, Williams Syndrome, 22q11.2 Deletion Syndrome, Sensorimotor Integration
Interventions: Not listed
Lead sponsor: Healing Hope International; Other
Eligibility: 4 Years to 12 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2036
U.S. locations: 1
States / cities: The Woodlands, Texas

Conditions: Hypoxia-Ischemia, Brain, Heart Arrest, Status Epilepticus, Refractory Status Epilepticus, Seizures, Anoxic-Ischemic Encephalopathy, Anoxia-Ischemia, Cerebral
Interventions: Burst Suppression EEG Target Intravenous Anesthesia, Seizure Suppression EEG Target Intravenous Anesthesia; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: Device (servo-regulated cooling), Control (standard practice); Device · Other
Lead sponsor: Stanford University; Other
Eligibility: Up to 6 Hours
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 9
States / cities: Loma Linda, California • Madera, California • Oakland, California + 5 more

Conditions: Neonatal Encephalopathy, Neonatal Encephalopathy (Neonatal Hypoxic-ischemic Encephalopathy), Neonatal Encephalopathy, Unspecified
Interventions: CergenX Wave; Device
Lead sponsor: CergenX Limited; Industry
Eligibility: 36 Weeks and older
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
Interventions: Cool-Cap; Device
Lead sponsor: Olympic Medical; Industry
Eligibility: 1 Hour to 6 Hours
Enrollment: 235 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2003
U.S. locations: 19
States / cities: Little Rock, Arkansas • Oakland, California • San Diego, California + 15 more

Conditions: Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic, Hypoxic-Ischemic Encephalopathy, Ischemic-Hypoxic Encephalopathy
Interventions: Hypothermia, Normothermic Control; Device · Procedure
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: 33 Weeks to 35 Weeks
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 18
States / cities: Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 14 more

Conditions: Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
Interventions: Methylphenidate; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mild Hypoxic Ischemic Encephalopathy of Newborn
Interventions: Normothermia, Whole body therapeutic hypothermia; Procedure
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 36 Weeks and older
Enrollment: 460 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2029
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: Holding during cooling; Other
Lead sponsor: Alexa Craig; Other
Eligibility: 24 Hours to 3 Days
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Portland, Maine

Conditions: Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia, Hypoxia-Ischemia, Brain, Heart Arrest, Stroke, Intracranial Hemorrhages, Coma, Persistent Vegetative State
Interventions: Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product, Valproate Sodium, Fosphenytoin; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Months to 70 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Interventions: portable MRI scanner; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure Newborn
Interventions: Levetiracetam Injection, Phenobarbital Sodium Injection; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: Up to 1 Month
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: San Diego, California • Minneapolis, Minnesota

Conditions: Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure, Meconium Aspiration Syndrome, Intracranial Hemorrhages, Neonatal Hypotension
Interventions: Room air; Other
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 55 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Neonatal Encephalopathy
Interventions: Sildenafil, Ora-Blend; Drug
Lead sponsor: Pia Wintermark; Other
Eligibility: 0 Minutes to 48 Hours
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2031
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Hypoxic-Ischemic Encephalopathy, Brain Injury, Neonatal Seizure
Interventions: Neurologic examination; Other
Lead sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre; Other
Eligibility: Up to 6 Hours
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 4
States / cities: Detroit, Michigan • Columbus, Ohio • Providence, Rhode Island + 1 more

Conditions: Perinatal Stroke, Hypoxic-ischemic Encephalopathy, White Matter Injury
Interventions: Increased protein; Dietary Supplement
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 2 Days to 3 Weeks
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Encephalopathy, Hypoxic-Ischemic
Interventions: Clonidine (Duraclon®); Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 35 Weeks to 42 Weeks
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: Melatonin, Magnetic Resonance Imaging, Pharmacokinetics, Neurological Outcome Assessment; Drug · Other · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: Up to 6 Hours
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 2
States / cities: Gainesville, Florida • Orlando, Florida

Search by objective public record fields.

Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study

Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates

CEUS Evaluation of Hypoxic Ischemic Injury

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation

Darbe Administration in Newborns Undergoing Cooling for Encephalopathy

Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

California Transport Cooling Trial

Newborn Brain Assessment - CergenX Wave

CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy

Preemie Hypothermia for Neonatal Encephalopathy

Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness

Cool Prime Comparative Effectiveness Study for Mild HIE

Holding, Stress, and Bonding During Therapeutic Hypothermia

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

Identification of Brain Injury Using Portable MRI

A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures

Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities

Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia

Prospective Research in Infants With Mild Encephalopathy

Protein Supplementation in Infants With Brain Injury

Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia