- Conditions
- Hypoxic-Ischemic Encephalopathy
- Interventions
- Optical Coherence Tomography
- Device
- Lead sponsor
- Duke University
- Other
- Eligibility
- Up to 20 Days
- Enrollment
- 57 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2021
- U.S. locations
- 2
- States / cities
- Durham, North Carolina • Salt Lake City, Utah
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Showing 25–48
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- Conditions
- Hypoxic Ischemic Encephalopathy
- Interventions
- Topiramate, Placebo
- Drug
- Lead sponsor
- Kristin R Hoffman
- Other
- Eligibility
- Up to 6 Hours
- Enrollment
- 34 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2022
- U.S. locations
- 1
- States / cities
- Sacramento, California
- Conditions
- HIE, TBI (Traumatic Brain Injury), TBI, Hemodynamic Instability, Hypoxic-Ischemic Encephalopathy
- Interventions
- MR Imaging
- Diagnostic Test
- Lead sponsor
- Children's Hospital Los Angeles
- Other
- Eligibility
- 1 Minute to 18 Years
- Enrollment
- 1,000 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2035
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- HIE - Perinatal Hypoxic - Ischemic Encephalopathy
- Interventions
- NIRS
- Device
- Lead sponsor
- Albany Medical College
- Other
- Eligibility
- 1 Minute to 2 Years
- Enrollment
- 101 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2022
- U.S. locations
- 1
- States / cities
- Albany, New York
- Conditions
- Hypoxic-ischemic Encephalopathy
- Interventions
- Dexmedetomidine
- Drug
- Lead sponsor
- Seattle Children's Hospital
- Other
- Eligibility
- 1 Hour to 1 Day
- Enrollment
- 7 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hepatitis B Vaccination, Hypothermia, Newborn
- Interventions
- Hypothermia Protocol
- Other
- Lead sponsor
- Medical University of South Carolina
- Other
- Eligibility
- 0 Hours to 72 Hours
- Enrollment
- 9 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 1
- States / cities
- Charleston, South Carolina
- Conditions
- Hypoxic Ischaemic Encephalopathy (HIE), Premature Birth, Cerebral Palsy, Neurological Disorder
- Interventions
- Abecedarian Approach
- Behavioral
- Lead sponsor
- University of Wisconsin, Madison
- Other
- Eligibility
- Up to 5 Years
- Enrollment
- 225 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2030
- U.S. locations
- 1
- States / cities
- Madison, Wisconsin
- Conditions
- Neonatal Hypoxic Ischemic Encephalopathy
- Interventions
- infusion of autologous cord blood, Neurodevelopmental outcomes
- Biological · Other
- Lead sponsor
- Michael Cotten
- Other
- Eligibility
- Up to 14 Days
- Enrollment
- 52 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2017
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Neonatal Seizure, Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Seizure Newborn
- Interventions
- Levetiracetam Injection, Phenobarbital Sodium Injection
- Drug
- Lead sponsor
- University of California, San Diego
- Other
- Eligibility
- Up to 1 Month
- Enrollment
- 133 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2027
- U.S. locations
- 2
- States / cities
- San Diego, California • Minneapolis, Minnesota
- Conditions
- Hypoxic-Ischemic Encephalopathy
- Interventions
- Developmental Outcomes
- Other
- Lead sponsor
- University of Florida
- Other
- Eligibility
- 18 Months to 20 Months
- Enrollment
- 21 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2018
- U.S. locations
- 1
- States / cities
- Gainesville, Florida
- Conditions
- Mild Hypoxic Ischemic Encephalopathy of Newborn
- Interventions
- Normothermia, Whole body therapeutic hypothermia
- Procedure
- Lead sponsor
- University of Texas Southwestern Medical Center
- Other
- Eligibility
- 36 Weeks and older
- Enrollment
- 460 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2029
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Hypoxic-ischemic Encephalopathy
- Interventions
- erythropoietin
- Drug
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- Up to 24 Hours
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke, Cerebral Edema, Anoxic Brain Injury
- Interventions
- Lung Protective Ventilation
- Procedure
- Lead sponsor
- Colin Grissom
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 728 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2026
- U.S. locations
- 1
- States / cities
- Murray, Utah
- Conditions
- Hypoxia-Ischemia, Brain, Signs and Symptoms
- Interventions
- Diffuse optical spectroscopy
- Device
- Lead sponsor
- University of California, Irvine
- Other
- Eligibility
- 20 Years and older
- Enrollment
- 78 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011
- U.S. locations
- 1
- States / cities
- Irvine, California
- Conditions
- Hypoxia-Ischemia, Brain
- Interventions
- taVNS
- Device
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 7 Years to 18 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
- Interventions
- Prospective Clinical and Neurodevelopmental Data Collection
- Other
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 31 Weeks to 42 Weeks
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Interventions
- TAK-935, Placebo
- Drug
- Lead sponsor
- Takeda
- Industry
- Eligibility
- 2 Years to 17 Years
- Enrollment
- 141 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 15
- States / cities
- Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 12 more
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder), Cerebral Palsy (CP), Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment, Cerebral Palsy Infantile, Cerebral Palsy Spastic Hemiplegic, Cerebral Palsy, Dyskinetic, Autism Spectrum Disorder, Autism Spectrum Disorder (ASD, Hypoxic Ischemic Encephalopathy, Hypoxic Ischemic Encephalopathy (HIE), Traumatic Brain Injury (TBI), Sensory Processing Disorder, Chromosomal Abnormalities, Genetic Disorders, Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS), RETT Syndrome With Proven MECP2 Mutation, Williams Syndrome, 22q11.2 Deletion Syndrome, Sensorimotor Integration
- Interventions
- Not listed
- Lead sponsor
- Healing Hope International
- Other
- Eligibility
- 4 Years to 12 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2036
- U.S. locations
- 1
- States / cities
- The Woodlands, Texas
- Conditions
- Hypoxic Ischemic Encephalopathy
- Interventions
- Darbepoetin alfa, Placebo
- Drug
- Lead sponsor
- University of Utah
- Other
- Eligibility
- Up to 24 Hours
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 7
- States / cities
- Albuquerque, New Mexico • Nashville, Tennessee • Ogden, Utah + 3 more
- Conditions
- Hypoxic-Ischemic Encephalopathy
- Interventions
- Holding during cooling
- Other
- Lead sponsor
- Alexa Craig
- Other
- Eligibility
- 24 Hours to 3 Days
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017
- U.S. locations
- 1
- States / cities
- Portland, Maine
- Conditions
- Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
- Interventions
- Cool-Cap
- Device
- Lead sponsor
- Olympic Medical
- Industry
- Eligibility
- 1 Hour to 6 Hours
- Enrollment
- 235 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 1999 – 2003
- U.S. locations
- 19
- States / cities
- Little Rock, Arkansas • Oakland, California • San Diego, California + 15 more
- Conditions
- Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Caffeine
- Interventions
- Caffeine citrate
- Drug
- Lead sponsor
- University of Arkansas
- Other
- Eligibility
- 0 Hours to 24 Hours
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024
- U.S. locations
- 2
- States / cities
- Little Rock, Arkansas
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
- Interventions
- Therapeutic Hypothermia
- Device
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 1,158 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 76
- States / cities
- Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more
- Conditions
- Severe Hypoxic-ischemic Encephalopathy
- Interventions
- HPDSC, Cord blood
- Drug
- Lead sponsor
- New York Medical College
- Other
- Eligibility
- 1 Minute to 6 Hours
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2022
- U.S. locations
- 1
- States / cities
- Valhalla, New York