Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results come from ClinicalTrials.gov. When the live registry is unavailable, a clearly labeled stored copy may be shown.

Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 31, 2026, 11:19 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1177–1200 of 1,884 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Impaired Cognition Clear all
Completed Not applicable Interventional

Fitness for Brain Optimization for Late-Life Depression

NCT04670510
View directory record Official record
Conditions
Depression in Old Age
Interventions
On-site AE, At-home AE, Social Engagement (SE)
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Not applicable Interventional Results available

A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events

NCT00736125
View directory record Official record
Conditions
Postoperative Complications, Memory Disorders
Interventions
pulsatile saline lavage, carbon dioxide lavage
Device
Lead sponsor
Kinamed Incorporated
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 31, 2026, 11:19 AM EDT
Terminated Phase 3 Interventional Results available

Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10

NCT00754013
View directory record Official record
Conditions
Down Syndrome, Cognitive Dysfunction
Interventions
Aricept (Donepezil hydrochloride), Placebo
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
6 Years to 10 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
2
States / cities
San Antonio, Texas • Herndon, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Oct 31, 2026, 11:19 AM EDT
Terminated Phase 3 Interventional Results available

An Extension To The B1451006 Protocol To Evaluate The Safety and Efficacy of Dimebon In Subjects With Moderate-to-Severe Alzheimer's Disease

NCT01066546
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Dimebon tablet for oral administration
Drug
Lead sponsor
Pfizer
Industry
Eligibility
50 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
5
States / cities
Costa Mesa, California • Encino, California • Los Alamitos, California + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2012 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Health Research on Musical Arts

NCT04137913
View directory record Official record
Conditions
Cognitive Impairment, Creativity
Interventions
Musical arts intervention
Behavioral
Lead sponsor
William Marsh Rice University
Other
Eligibility
18 Years to 90 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 31, 2026, 11:19 AM EDT
Recruiting Not applicable Interventional

Voice Technology-Based Self-Management Intervention

NCT06982261
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Voice-activated smart speakers
Other
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Autoimmune Features of Neurodegenerative Disorders

NCT04239079
View directory record Official record
Conditions
Parkinson Disease, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
55 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Phase 1 Interventional Results available

Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome

NCT02738450
View directory record Official record
Conditions
Down Syndrome
Interventions
ACI-24 low dose, ACI-24 high dose, Placebo
Biological
Lead sponsor
AC Immune SA
Industry
Eligibility
25 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
4
States / cities
Phoenix, Arizona • La Jolla, California • Baltimore, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2021 · Synced Oct 31, 2026, 11:19 AM EDT
Terminated Phase 4 Interventional Results available

Cognitive Protection - Dexmedetomidine and Cognitive Reserve

NCT00455143
View directory record Official record
Conditions
Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
Interventions
Precedex (Dexmedetomidine), Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
65 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training

NCT03272711
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
Vortioxetine 10 mg, Cognitive training program
Drug · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 31, 2026, 11:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Brigance Assessment Of Individual Neurodevelopment In Young Children With Sickle Cell Disease- 2

NCT01123863
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
Brigance Preschool Screen -II
Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
3 Years to 4 Years
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Music, Sleep and Dementia Study

NCT04157244
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Insomnia, Hypersomnia, Cognitive Impairment, Cognitive Decline, Mild Cognitive Impairment, Frontotemporal Dementia, Neurocognitive Disorders, Vascular Dementia, Sleep Disorder, Memory Impairment
Interventions
Tailored music listening intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 110 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Oct 31, 2026, 11:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Music Therapy Study for Blood Cancer Survivors With Cognitive Difficulties

NCT07052916
View directory record Official record
Conditions
Blood Cancer, Lymphoma, Leukemia, Myeloma
Interventions
Music Therapy/MT, Therapist-Attention Music Education/TAME Control
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Recruiting Phase 3 Interventional

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

NCT06976216
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
KarXT, KarX-EC, Placebo
Drug · Other
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
60 Years to 85 Years
Enrollment
586 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
28
States / cities
Long Beach, California • Redlands, California • Basalt, Colorado + 24 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Phase 4 Interventional

Water-based Activity to Enhance Recall in Veterans: A Randomized Clinical Trial

NCT04296565
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Usual Care, WATER+CT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 90 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Gamma-tACS on Memory and Sleep

NCT05907707
View directory record Official record
Conditions
Transcranial Alternating Current Stimulation, Aging, Cognitive Decline, Memory, Sleep
Interventions
Gamma transcranial alternating current stimulation, Control transcranial alternating current stimulation, EEG headband, Actigraphy wristband
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 31, 2026, 11:19 AM EDT
Recruiting Phase 1Phase 2 Interventional

Stem Cell Therapy for Early Alzheimer's Disease

NCT06775964
View directory record Official record
Conditions
Cognitive Dysfunction
Interventions
adMSC
Biological
Lead sponsor
Paul E Schulz
Other
Eligibility
60 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Iowa Healthy and Active Minds Study

NCT01165463
View directory record Official record
Conditions
Visual Processing Speed
Interventions
SOPT basic training, Crossword Puzzles, SOPT booster training
Behavioral
Lead sponsor
Fredric D Wolinsky
Other
Eligibility
50 Years and older
Enrollment
681 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 21, 2019 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Phase 4 Interventional Results available

Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy

NCT02213900
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Post-traumatic Stress Disorder, Depression, Anxiety
Interventions
Haloperidol, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2017 · Synced Oct 31, 2026, 11:19 AM EDT
Active, not recruiting Phase 3 Interventional Results available

A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

NCT04437511
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Donanemab, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
60 Years to 85 Years
Enrollment
1,736 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
185
States / cities
Gilbert, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 146 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 31, 2026, 11:19 AM EDT
Not listed Phase 1Phase 2 Interventional

Trial of Novel Oral Zinc Cysteine Preparation in Alzheimer's Disease

NCT01099332
View directory record Official record
Conditions
Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Gastro-retentive zinc cysteine tablet, Tablet identical physically to active comparator containing some lactose
Other
Lead sponsor
Adeona Pharmaceuticals
Industry
Eligibility
55 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
3
States / cities
Clearwater, Florida • Holiday, Florida • Port Richey, Florida
Source: ClinicalTrials.gov public record
Updated Jan 28, 2011 · Synced Oct 31, 2026, 11:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline

NCT00099567
View directory record Official record
Conditions
Cognitive Decline
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
70 Years to 79 Years
Enrollment
2,632 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2002
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 1, 2005 · Synced Oct 31, 2026, 11:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cognitive Impairment in Kidney Disease

NCT00905619
View directory record Official record
Conditions
Kidney Insufficiency, Chronic
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2017 · Synced Oct 31, 2026, 11:19 AM EDT
Completed Not applicable Interventional

fMRI Connectivity in Fracture Hip Patients

NCT02997930
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
fMRI, Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 99 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 12, 2019 · Synced Oct 31, 2026, 11:19 AM EDT